Impaired adaptive immune response in COVID-19 convalescent patients with hematological malignanciesArticle Published on 2023-04-012023-07-11 Journal: European journal of haematology [Category] COVID19(2023년), [키워드] activated T cells Adaptive immunity COVID-19 convalescents Hematological malignancies Lymphocyte subpopulations regulatory T cells. T cells TCRɣ/ƍ TCRα/ß [DOI] 10.1111/ejh.13916 PMC 바로가기
Diagnostic and management strategies for chronic hepatitis E infectionArticle Published on 2023-02-012023-06-10 Journal: Expert review of anti-infective therapy [Category] E형 간염, [키워드] Hematological malignancies hepatitis E virus ribavirin Solid organ transplant recipients zoonotic infection. [DOI] 10.1080/14787210.2023.2166932 PMC 바로가기
Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysisReview Published on 2023-02-012023-07-10 Journal: Hematological oncology [Category] COVID19(2023년), [키워드] COVID-19 determinants Hematological malignancies Mortality Severity. [DOI] 10.1002/hon.3084 PMC 바로가기 [Article Type] Review
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Early administration of remdesivir plus convalescent plasma therapy is effective to treat COVID-19 pneumonia in B-cell depleted patients with hematological malignanciesArticle Published on 2022-10-012023-07-10 Journal: Annals of Hematology [Category] COVID19(2023년), [키워드] convalescent plasma treatment COVID-19 Hematological malignancies immunodeficiency Remdesivir SARS-CoV-2. [DOI] 10.1007/s00277-022-04924-6 PMC 바로가기
A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies혈액암이 있는 성인 환자의 SARS-CoV-2 백신 1차 및 2차 접종에 대한 면역 반응의 체계적인 검토 및 메타 분석Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval 95%CI affected affecting anti-CD20 therapy antibody Antibody detection Antibody Response article booster dose booster doses calculated Cancer patients chronic lymphocytic leukemia CLL Complete conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop Diagnosis disease doses evaluate first dose Google Google Scholar healthy subject healthy subjects Hematological malignancies Hematological malignancy higher risk highlight highlighting immune response Immunity immunization Immunocompromised immunogenicity immunosuppressive IMPROVE kinase inhibitors less leukemia lowest Lymphocytic leukemia lymphoma malignancy measure Meta-analysis mRNA mRNA-1273 Myeloma Patient Primary outcome response rate SARS-CoV-2 SARS-CoV-2 vaccine second dose secondary outcome Secondary outcomes seropositive Seropositivity severe coronavirus disease solid tumor solid tumors status subgroup subtype systematic review systematic review. the disease the vaccine tumors tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Vaccine vaccine dose vaccine's immunogenicity Web of Science [DOI] 10.1016/j.intimp.2022.109046 PMC 바로가기 [Article Type] Review
Immunosuppressed non-responders to two doses of mRNA SARS-CoV-2 vaccines achieve an immune response comparable to those of immunocompetent individuals after a third doseArticle Published on 2022-09-012022-11-15 Journal: Hormones (Athens, Greece) [Category] COVID19(2023년), SARS, 진단, [키워드] anti-CD20 antibody response against Antibody titer appear Autoimmune disorders cancers cascade cell-mediated immune comparable disease dose elevated Glucocorticoids Hematological malignancies immune response Immunocompromised Immunosuppressed Immunosuppression individual induce inhibitor methotrexate MMF monoclonal antibody MOST mRNA mRNA SARS-CoV-2 vaccines. neutralizing antibody non-responder Patient proportion Protein Rapamycin recipient S protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Signaling solid cancers solid organ transplant suggested the SARS-CoV-2 the SARS-CoV-2 virus third dose transplantation Treatment Vaccine Vaccines variety while [DOI] 10.1007/s42000-022-00365-y PMC 바로가기
Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patientsArticle Published on 2022-09-012023-07-09 Journal: Annals of Hematology [Category] COVID19(2023년), [키워드] Allogeneic stem cell transplantation Autologous stem cell transplantation Bayesian networks CAR-T therapy chronic lymphocytic leukemia COVID-19 Hematological malignancies Immunocompromised patients Moderna mRNA-1273 mRNA vaccine. Non-Hodgkin Lymphoma Pfizer-BioNTech BNT162b2 Probabilistic graphical models respiratory virus SARS-CoV-2 vaccines [DOI] 10.1007/s00277-022-04906-8 PMC 바로가기
Evaluation of serological response to anti-SARS-CoV-2 mRNA vaccination in hematological patients혈액학적 환자에서 anti-SARS-CoV-2 mRNA 백신접종에 대한 혈청학적 반응 평가Article Published on 2022-08-082022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Administered anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccination Anti-spike anti-Spike IgG anti-spike IgG level antibody Antibody titer association Cell Cohort cohort of patient Concentration control arm control group Cutoff demographic variable difference drug Effect evaluated greater health worker healthy healthy subjects hematological Hematological malignancies Hematological malignancy heterogeneous highest identify IgG IgG titer immune system immunoassay Immunocompromised patients Immunosuppression implication inhibitor Italy leukemia Microparticle molecular mRNA mRNA vaccination mRNA vaccine onco-hematology. parameter pathology Patient patients performed Predictive reached reduced reported SARS-CoV-2 SARS-CoV-2 antibody second dose seroconversion rate serological response shown significantly lower spike IgG statistical significance steroid stratified Surveillance the mean the patient Therapies therapy treated tyrosine underlying disease vaccination Vaccine was reduced [DOI] 10.3389/fimmu.2022.892331 PMC 바로가기 [Article Type] Article
Single-cell sorting based on secreted products for functionally defined cell therapies Reviews Published on 2022-07-222022-10-05 Journal: Microsystems & Nanoengineering [Category] 바이오마커, [키워드] accumulating addition Analysis approach approaches autoimmune disorder Cell Cell therapy cellular cellular therapy Critical defined disease Efficacy exacerbated fibrosis functional Genetic Hematological malignancies in vivo individual cell killing labeling lack Migration molecular neurodegenerative disorder patients proliferation remained reporter robust secreted secretion Single Cell single-cell solid tumor therapeutic therapeutic potential Therapies therapy triggering unmet need while [DOI] 10.1038/s41378-022-00422-x [Article Type] Reviews