Third Early “Booster” Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody ResponsesArticle Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] administration allogeneic HSCT Anti-spike antibody Antibody Response Beta BNT162b2 vaccine booster Breakthrough infection can be used circulation correlated COVID-19 COVID-19 vaccine Delta delta variant dose enzyme France healthy hematopoietic high-risk population HSCT HSCT immunocompromised patients HSCT recipient humoral Humoral response immune immune protection Immune suppression immunoassay Immunocompromised immunocompromised individuals Immunocompromised patients Immunosuppressed individual marker monoclonal antibody Neutralization assay neutralization titer Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody response omicron preventive measure PROTECT Protein question raised recipient recipients response SARS-CoV-2 SARS-CoV-2 variant sensitivity significantly lower STEM Strategy Support tested the vaccine Transplant vaccination vaccine dose variant variant of concern variants [DOI] 10.3390/v14091928 PMC 바로가기
Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34+ Hematopoietic Stem Cells in Umbilical Cord Blood of NewbornsArticle Published on 2022-08-012022-11-15 Journal: Bulletin of experimental biology and medicine [Category] 바이오마커, [키워드] Analysis Blood CD34 Cell collected composed content control group CORD COVID-19 form groups healthy hematopoietic Hematopoietic stem cell hematopoietic stem cells leukocyte Mild moderate no significant difference Patient phenotype Pregnancy STEM umbilical cord blood umbilical cord blood. Volume women [DOI] 10.1007/s10517-022-05575-3 PMC 바로가기
Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort StudyResearch article Published on 2022-07-012022-10-05 Journal: Transplantation and cellular therapy [Category] 유전자 메커니즘, 진단, [키워드] 95% CI 95% confidence interval Adolescent Adults adverse outcome age Allogeneic allogeneic HSCT autologous HSCT Cell center children clinical Comorbidity COVID-19 COVID-19 diagnosis Cox regression analysis diagnosed with COVID-19 Early adolescent and young adult estimates Follow-up General population hazard ratio hematopoietic Hematopoietic stem cell high risk HSCT HSCT recipient HSCT recipients interquartile range IQR Marrow mechanical ventilation Mild Mortality outcome Patient pediatric Primary outcome recipient recipients reported required risk factor secondary outcome STEM Stem cell transplantation subset supplemental oxygen survival Transplant transplantation [DOI] 10.1016/j.jtct.2022.06.026 [Article Type] Research article
Allogeneic Hematopoietic Stem Cell Transplant for Acute Lymphoblastic Leukemia in a Pediatric Patient After COVID-19 Infection Complicated by MIS-CShort communication Published on 2022-05-012022-10-05 Journal: Journal of pediatric health care : official public [Category] 바이오마커, [키워드] Care Case report Chemotherapy children Clinical course Course COVID-19 COVID-19 infection COVID-19 pandemic disease disease course hematopoietic Hematopoietic stem cell transplant impacted implication individuals Infection Inflammatory initial knowledge lack leukemia MIS-C oncology oncology patients outcome Patient pediatric pediatrics recommendation Research risk STEM Stem cell transplantation syndrome the disease Transplant Treatment [DOI] 10.1016/j.pedhc.2022.01.006 [Article Type] Short communication
B Cell Aplasia Is the Most Powerful Predictive Marker for Poor Humoral Response after BNT162b2 mRNA SARS-CoV-2 Vaccination in Recipients of Allogeneic Hematopoietic Stem Cell TransplantationB 세포 무형성은 동종 조혈모세포 이식 환자에서 BNT162b2 mRNA SARS-CoV-2 백신 접종 후 불량한 체액 반응에 대한 가장 강력한 예측 마커입니다Article Published on 2022-05-012022-09-11 Journal: Transplantation and cellular therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval absence administration age allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Analysis analyzed anti-SARS-CoV-2 vaccination Antibody Response Antibody responses aplasia B cell B cells B-cell BNT162b2 BNT162b2 mRNA CD4 CD8 characteristic close monitoring Cohort COVID-19 Donor Efficacy entire cohort evaluate evaluated Factor hematopoietic Hematopoietic stem cell highest HSCT humoral Humoral response immune response Immune status Immunosuppressed immunosuppressed patients injection lymphocyte Lymphocyte count lymphopenia median MOST mRNA natural killer cell Natural killer cells Odds ratio of BNT162b2 Patient Poor predict provided recipient recipients reported responders response response rate SARS-CoV-2 SARS-CoV-2 mRNA SARS-CoV-2 vaccination SARS-CoV-2 vaccine Specific STEM stem cell Stem cell transplantation T cell T cells the antibody response transplantation Treatment Univariate analysis Vaccine were assessed [DOI] 10.1016/j.jtct.2022.02.018 PMC 바로가기 [Article Type] Article
Antibody Response to SARS-CoV-2 Vaccination in Patients following Allogeneic Hematopoietic Cell Transplantation동종 조혈 세포 이식 후 환자에서 SARS-CoV-2 백신 접종에 대한 항체 반응Article Published on 2022-04-012022-09-11 Journal: Transplantation and cellular therapy [Category] COVID19(2023년), SARS, 치료법, [키워드] age Allogeneic Allogeneic hematopoietic cell transplantation Analysis antibody antibody levels Antibody Response Antibody titer Antibody titers approved BNT162b2 Cell cell transplantation chronic GVHD Cohort conditioning regimen conducted Critical disease domain Efficacy examined Factor Graft-versus-host disease group GVHD had no healthy control healthy controls healthy volunteers hematopoietic Hematopoietic cell transplantation highest homogenous humoral immune response IgA IgG IgM immune response immune responses Immunocompromised patients Immunosuppression information intensity Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 nucleocapsid protein pandemic Patient physician reactivity receiving Receptor-binding domain recipient recipients regimen response revaccination S1 and S2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 pandemic SARS-CoV-2 vaccination second dose significantly lower single center spike glycoprotein stratified subunit Switzerland the SARS-CoV-2 the vaccine transplantation Treatment underlying disease vaccination Vaccine waned was performed [DOI] 10.1016/j.jtct.2022.01.019 PMC 바로가기 [Article Type] Article
In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료Article Published on 2022-04-012022-09-11 Journal: Human gene therapy [Category] COVID19(2023년), SARS, 변종, [키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin [DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical SiblingsImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] 10x Analysis approach BNT162b2 Cell cellular chimerism clinical trial Combined COVID - 19 declining disease Donor dose Europe feasible female genetic profile hematopoietic Hematopoietic stem cell Hematopoietic stem cell transplantation (HSCT) humoral immune responsiveness Immunity immunocompetence immunological tolerance immunology Immunosuppression induce induction induction of tolerance Infection kidney Kidney transplantation lymphoid male Microscope molecular monotherapy mRNA vaccine occurred pandemic Patient patients previous study protocol Quality of life rejection sibling Specific Stanford STEM Stem cell transplantation steroid T cell the SARS-CoV-2 Tolerance transplantation was performed [DOI] 10.3389/fimmu.2022.796456 PMC 바로가기 [Article Type] Immunology
An Exploration of COVID-19 Impact and Vaccine Hesitancy in Parents of Pediatric Hematopoietic Stem Cell Transplant (HCT) Recipients Research Published on 2022-01-242022-10-05 Journal: Bone marrow transplantation [Category] COVID19(2023년), SARS, 임상, [키워드] age approval Cell children concern conducted COVID-19 COVID-19 vaccine Critical cross-sectional distress exploration exposure Facebook Factor family HCT hematopoietic Hesitancy Impact Improving information majority media National pandemic parent parental paucity of data pediatric recipient recipients recommendation recruited scale score Side effects Standard deviation STEM Transplant Vaccine VHS were used white [DOI] 10.1038/s41409-022-01587-9 [Article Type] Research
A Portrait of SARS-CoV-2 Infection in Patients Undergoing Hematopoietic Cell Transplantation: A Systematic Review of the LiteratureSystematic Review Published on 2022-01-132022-10-31 Journal: Current Oncology [Category] COVID-19, SARS, [키워드] 95% CI age Allogeneic autologous Cell Controlled COVID-19 decreased mortality described determine Efficacy Efficacy and safety Factor Features HCT hematopoietic Hematopoietic cell transplant high risk ICU admission immune dysregulation increased mortality literature management Meta-analysis morbidity and mortality Mortality mortality rate MOST OVID pediatric performance Platelet Portrait Potential treatment presenting Prognostic factors recipient recipients reported required review Risk of bias SARS-CoV-2 Symptom systematic review Treatment Vaccine with COVID-19 [DOI] 10.3390/curroncol29010030 PMC 바로가기 [Article Type] Systematic Review