Hemin competitively inhibits HSPA8 ATPase activity mitigating its foldase functionarticle Published on 2024-02-282024-09-01 Journal: Archives of Biochemistry and Biophysics [Category] 말라리아, [키워드] Competitive-inhibition Foldase hemin HSPA8 malaria oxidative stress [Article Type] article
Development and Characterization of Novel Chitosan-Coated Curcumin Nanophytosomes for Treating Drug-Resistant MalariaArticle Published on 2024-01-312024-09-10 Journal: Assay Drug Dev Technol [Category] 말라리아, [키워드] Curcumin hemin malaria nanophytosomes. PMC 바로가기
Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction헴 옥시게나제-1 유도를 통한 코로나19 치료의 새로운 후보인 헤민Article Published on 2021-11-022022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antimicrobial therapy antiviral activity Antiviral effect antiviral effects Biliverdin byproduct causative agent cells coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death rate effective enzyme expression expression vector Free growth heme hemin in vitro inducer Inflammatory response inhibit investigated iron oxidative stress Protein reduce reported respiratory restrict Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested suppresse suppressed therapeutic transient expression treating COVID-19 Treatment Viral viral infection viral infections virus [DOI] 10.1038/s41598-021-01054-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Proteins Bind to Hemoglobin and Its MetabolitesSARS-CoV-2 단백질은 헤모글로빈과 그 대사산물에 결합합니다Article Published on 2021-08-212022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption affinity column Analysis analyzed approaches bind binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain explain FIVE hematological heme hemin hemoglobin identify in silico analysis in vitro inhibitory effect Interaction M metabolite Microarray motif motifs N N protein N-terminal domain Nsp3 Nsp7 NTD nucleoprotein peptide peptides Plaque assay Protein protein–protein binding Proteins proteomic Proteomic analysis proteomics protoporphyrin RBD RBD region receptor recruit recruitment Replication respiratory S protein SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus spike Spike protein suppressed the N protein the RBD the S protein the spike protein these compound these compounds Vero cells Viral viral replication virus was used [DOI] 10.3390/ijms22169035 PMC 바로가기 [Article Type] Article
A Rolling Circle-Amplified G-Quadruplex/Hemin DNAzyme for Chemiluminescence Immunoassay of the SARS-CoV-2 ProteinSARS-CoV-2 단백질의 화학발광 면역분석을 위한 롤링 서클 증폭 G-사중체/헤민 DNA자임Article Published on 2021-07-202022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] Accuracy Analysis applicability chemiluminescence complex Concentration Conjugates coronavirus epidemic demonstrated detectable Detection limit Diagnosis DNA DNA sequence hemin hydrogen hydrogen peroxide intrinsic luminol magnitude Oxidation pair primer produced Protein released Research Rolling Rolling circle amplification SARS-CoV-2 protein sensitive serum sample serum samples target protein the SARS-CoV-2 triggered [DOI] 10.1021/acs.analchem.1c02229 PMC 바로가기 [Article Type] Article
In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem barkTrema orientalis (Linn.) 줄기 껍질 추출물 및 분획의 시험관 내 항말라리아 활성 및 예방 잠재력Research Article Published on 2017-08-152024-08-12 Journal: BMC Complementary and Alternative Medicine [Category] 말라리아, [키워드] Chloroquine Ferriprotoporphyrin (ix) hemin Hemozoin Plasmodium bergei Sulfadoxine-pyrimetamine Trema orientalis [DOI] 10.1186/s12906-017-1914-x PMC 바로가기 [Article Type] Research Article