Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspectivearticle Published on 2023-01-272024-09-05 Journal: AMB Express [Category] update2024, [키워드] Heparanase Monkeypox SARS-CoV-2 [DOI] 10.1186/s13568-023-01517-y PMC 바로가기 [Article Type] article
Vascular Endothelial Glycocalyx Damage and Potential Targeted Therapy in COVID-19Review Published on 2022-06-192023-07-09 Journal: Cells [Category] COVID19(2023년), [키워드] COVID-19 endothelial cells glycocalyx Heparanase Syndecan-1 [DOI] 10.3390/cells11121972 PMC 바로가기 [Article Type] Review
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19Article Published on 2022-04-132023-07-08 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] COVID-19 Heparanase inflammatory cytokine release Macrophage SARS-CoV-2 [DOI] 10.1128/jvi.00057-22 PMC 바로가기
Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral InfectionsArticle Published on 2022-02-192023-07-07 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), [키워드] conformational analysis heparan sulfate Heparanase molecular dynamics simulations pixatimod (PG545). [DOI] 10.1002/chem.202104222 PMC 바로가기
Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathyCardiovascular System & Vascular Biology Published on 2021-07-302022-10-28 Journal: Bioscience Reports [Category] COVID-19, SARS, [키워드] accompanied acute respiratory syndrome blocked caused cell entry clotting Coagulopathy complications COVID-19 COVID-19 pandemic disease disorder ENhance Evidence heparan sulfate Heparanase heparin hypercoagulability Increasing inhibitor involved molecular Novel coronavirus Pathologies Patient Pixatimod Prognosis Proteoglycan SARS-CoV-2 SARS-COV-2 infection severe complication subjects therapeutic interventions viral infections viruses [DOI] 10.1042/BSR20210290 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
Biomarkers of Hypercoagulability and Endothelial Cell Activation in Patients with Severe COVID-19 Admitted at the Intensive Care Unit. the Roadmap-COVID-19 Prospective Observational StudyConference abstract Published on 2020-11-042022-10-05 Journal: Blood [Category] 바이오마커, [키워드] Activation acute respiratory distress acute respiratory syndrome Algorithm Antithrombotic AP-HP ARDS Biomarker Blood coagulation calculated cause cellular change characterized clinically clotting factor Cluster Coagulation cohort study complications consecutive patient Control control group controls coronavirus coronavirus disease COVID-19 D-dimer decrease disease download effect of treatment endothelial Endothelial cell Endothelial dysfunction enrolled evaluate evaluated excessive inflammation expressing fibrinogen FVIII healthy individual Heparanase Hospitalized hypercoagulability ICU ICU admission ICU patient IL-6 IL-6 level increase indicate indicated inflammatory reaction Inhaled inhibitor intensive care unit intrinsic life-threatening LMWH management mandatory Microparticle moderate modify molecular weight monomer MRI Multisystem organ failure outcome Paris pathway Patient patients patients hospitalized patients with COVID-19 peak platelet activation Pneumonia Prospective Prospective Study Protein protein S ranged Ratio Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown significant decrease significantly STABLE syndrome table TFPI the mean the patient thrombin Thromboprophylaxis university von Willebrand factor were assessed with COVID-19 [DOI] 10.1182/blood-2020-140275 [Article Type] Conference abstract
Response to Maccio et al, “Multifactorial pathogenesis of COVID-19-related coagulopathy: Can defibrotide have a role in the early phases of coagulation disorders?”Comment Published on 2020-11-012023-07-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, [키워드] COVID-19 defibrotide Heparanase p38 mitogen-activated protein kinases thrombosis Vascular endothelium [DOI] 10.1111/jth.15088 PMC 바로가기 [Article Type] Comment
Increased Plasma Heparanase Activity in COVID-19 PatientsImmunology Published on 2020-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activity applied clinically contribute COVID-19 COVID-19 patient COVID-19 patients creatinine disease severity elevated endothelial Endothelial dysfunction enzyme glycocalyx damage healthy control Heparanase heparin Hypothesis Increased Inflammation inhibited inhibitor intensive care lactate dehydrogenase LMWH LMWH (low molecular weight heparin) low molecular weight molecular weight non-ICU patient pathogenesis of COVID-19 plasma Prophylactic reduced report significantly Therapeutic treatment vascular leakage were measured [DOI] 10.3389/fimmu.2020.575047 PMC 바로가기 [Article Type] Immunology
Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patientsReview Published on 2020-08-252022-10-04 Journal: EBioMedicine [Category] MERS, SARS, 치료법, [키워드] addition AKI, acute kidney injury Anticoagulant ARDS, acute respiratory distress syndrome chemokines clinical study COVID-19 COVID-19 patient COVID-19 patients COVID-19, coronavirus disease-2019 endothelial evaluate explained Extracellular functional GAGs, glycosaminoglycans Heparanase heparin Histones HPSE, heparanase HS, heparan sulphate ICU, Intensive care unit Inflammation Inflammatory Inflammatory diseases inhibition Interference IU, international unit kidney leukocyte LMWH LMWH, low molecular weight heparin low molecular weight heparin lung mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular weight Mortality NETs, neutrophil extracellular traps pathogenic mechanism Patient report responsible SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus sequence severe inflammation SGP, spike glycoprotein therapeutic dose therapeutic potential Treatment viral cellular entry [DOI] 10.1016/j.ebiom.2020.102969 PMC 바로가기 [Article Type] Review