Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary centerArticle Published on 2023-03-012023-06-09 Journal: Cancer Medicine [Category] B형 간염, [키워드] cirrhosis head and neck squamous cell cancer (HNSCC) hepatic dysfunction Hepatitis B virus (HBV) immune checkpoint inhibitor (ICI) survival [DOI] 10.1002/cam4.5469 PMC 바로가기
Inferior survival and frequent hepatic dysfunction in non-Hodgkin’s lymphoma patients with HBV infection: a systematic review and meta-analysisMeta-Analysis Published on 2022-12-012023-06-10 Journal: Hematology (Amsterdam, Netherlands) [Category] B형 간염, [키워드] Chronic HBV infection Complete Remission hepatic dysfunction Meta-analysis non-Hodgkin’s lymphoma overall survival Prognosis progression-free survival. [DOI] 10.1080/16078454.2021.2011546 [Article Type] Meta-Analysis
SARS-CoV-2 induced hepatic injuries and liver complicationsArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료기술, [키워드] abnormality acute respiratory syndrome ADE Affect Antibody-dependent enhancement Case fatality rate caused clinician Comorbidity Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patient demonstrated detectable diabetes disease Effect Fecal sample gastrointestinal tract globe HCC hepatic dysfunction hepatic injury hepatocellular Hepatocellular carcinoma hepatocyte highly pathogenic hypertension hypoxia identification Immunopathogenesis in vitro in vivo Infection investigated involved Ischemia liver Liver damage Liver injury mechanism mechanism of liver damage. molecular mechanism multifactorial Patient Psychological reported Research Respiratory samples rising RNA RT-PCR SARS-CoV-2 signaling pathways significantly Stress systemic inflammation Toxicity [DOI] 10.3389/fcimb.2022.726263 PMC 바로가기
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research
Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial캐나다에서 COVID-19로 병원에 입원한 환자의 치료를 위한 Remdesivir: 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-222022-09-11 Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI 95% confidence interval adverse event age Analysis assigned baseline Canada changes in Characteristics clinical outcomes Clinical severity conjunction Consent Controlled trial COVID-19 creatinine Data collection defined demographics dialysis duration of symptom Effect enrolment evaluated event followed by groups Health care health care systems Health Organization health systems hepatic dysfunction hospital Hospital mortality Hospital stay hospitals in-hospital mortality incidence intravenously mechanical ventilation mechanically ventilated Mortality no difference Open-label outcome oxygen Patient patients performed Pragmatic Primary outcome Randomized Randomized controlled trial randomized patient RCT receive receiving Relative risk Remdesivir risk secondary Secondary outcomes severity of symptom Sex significant effect solidarity Solidarity trial standard care Standard deviation Standard of care Standard-of-care Treatment Trial Trial registration ventilator-free day Ventilator-free days with COVID-19 World Health Organization [DOI] 10.1503/cmaj.211698 PMC 바로가기 [Article Type] Randomized Controlled Trial
Preeclampsia-Like Syndrome in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에 걸린 임산부의 자간전증 유사 증후군Case Reports Published on 2022-02-012022-09-11 Journal: Journal of obstetrics and gynaecology Canada : JOG [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] can be used coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection creating described diagnostic dosage English facilitate French growth growth factor healthy hepatic dysfunction hypertension male management manifestation Manifestations Maternal nous occur outcome Patient Placenta placenta growth factor placental preeclampsia Pregnancy pregnancy outcome pregnant pregnant women Prognostic factors Proteinuria secondary hypertension significantly supportive care syndrome was used [DOI] 10.1016/j.jogc.2021.09.015 PMC 바로가기 [Article Type] Case Reports
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다Article Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제, [키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread [DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article
High Prevalence of Pre-Existing Liver Abnormalities Identified Via Autopsies in COVID-19: Identification of a New Silent Risk Factor?Article Published on 2021-09-172022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] abnormality Admission albumin albumin level analysed antibodies arteriopathy Autopsy cirrhosis Cohort correlation COVID-19 COVID-19 patients death demonstrated disease English Evidence hepatic hepatic dysfunction hepatic pathology hospital Hospital admission hypertension identification Identified increased mortality indicated interferon dysregulation literature review liver Liver disease Liver function liver function tests moderate Mortality New observation outcome pathologist pathology Patient patients Post-mortem potential mechanism Prevalence reduced renal reported risk Risk factors risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection significantly significantly increased steatosis subsequent type 2 diabete venous Via [DOI] 10.3390/diagnostics11091703 PMC 바로가기 [Article Type] Article
The NIH Lipo-COVID Study: A Pilot NMR Investigation of Lipoprotein Subfractions and Other Metabolites in Patients with Severe COVID-19Article Published on 2021-08-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alteration Atherosclerosis beta-hydroxybutyrate branched-chain amino acid cholesterol complex interplay COVID-19 Diseases elevated evidenced HDL hepatic dysfunction Inflammation intensive care investigation LDL lipids lipoprotein lipoprotein X (LpX), lipoprotein Z (LpZ), GlycA marker metabolites NIH NMR NMR spectroscopy Other Participants Patient patients with COVID-19 pilot study plasma plasma lipoprotein Prognostic markers reduced reported respiratory viral infections SARS-CoV-2 severe COVID-19 triglycerides TRL utility was used [DOI] 10.3390/biomedicines9091090 PMC 바로가기 [Article Type] Article
Effect of COVID-19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey교정 QT 간격 및 Torsade de Pointes 유도에 대한 COVID-19 약물의 영향: 다기관 국가 조사 결과Multicenter Study Published on 2021-07-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 치료제, [키워드] addressed administration Amiodarone arrhythmia Atazanavir Azithromycin Chloroquine Cohort Combination combination therapy coronavirus coronavirus disease COVID-19 COVID-19 patient Critical death demonstrated during treatment Effect Favipiravir female gender furosemide heart failure hepatic dysfunction hospital hospitalised Hydroxychloroquine hypokalaemia incidence inclusion criteria Iran life-threatening Lopinavir Lopinavir-ritonavir Lopinavir/ritonavir medication medications multicenter National occurred oseltamivir Patient patients predicted Primary outcome Prospective Study QT interval QT prolongation QTc QTC prolongation Remdesivir renal reported Repurposed drug Repurposed drugs Result risk Ritonavir secondary outcome Secondary outcomes Side effect therapy Torsade de Pointes treated Treatment [DOI] 10.1111/ijcp.14182 PMC 바로가기 [Article Type] Multicenter Study