Prolonged Exposure to Remdesivir Inhibits the Human Ether-A-Go-Go-Related Gene Potassium CurrentArticle Published on 2023-07-302024-09-05 Journal: Journal of cardiovascular pharmacology [Category] update2024, [키워드] COVID-19 hERG KCNH2 QT interval Remdesivir torsades de pointes [DOI] 10.1097/FJC.0000000000001449 PMC 바로가기 [Article Type] Article
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessmentArticle Published on 2022-09-012022-11-16 Journal: Journal of Pharmacological and Toxicological Methods [Category] 신약개발, [키워드] Abstract Analysis Annual appear approach arising article assessments attrition automated clinical study COVID-19 drug effort FDA Giant global pandemic hERG ICHE14/S7B in vitro in vivo manuscript Perspective Pharmacology Prevent problem protocol QT correction Regulatory Safety Safety assessment safety pharmacology Society SPS Taking Volume [DOI] 10.1016/j.vascn.2022.107206 PMC 바로가기
Repurposing drugs as COVID-19 therapies: A toxicity evaluationCOVID-19 치료제로 약물 용도 변경: 독성 평가Review Published on 2022-07-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyzed anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity approved autophagy blockers chemical structures clinical trials contributed correlated COVID-19 CPE Cytopathic effect cytotoxicity database drug drug candidate drug candidates Drug interactions Drug repurposing Efficiency enrolled ether hERG High-throughput screening highlight house identify In vitro assay induce nonspecific pandemic Phospholipidosis profile repurposing SARS-CoV-2 Severe acute respiratory syndrome significantly Structure Toxicity [DOI] 10.1016/j.drudis.2022.04.001 PMC 바로가기 [Article Type] Review
HYDROXYCHLOROQUINE ATTENUATES HERG CHANNEL BY PROMOTING THE MEMBRANE CHANNEL DEGRADATION: EVIDENCES FOR QT-INTERVAL PROLONGATION IN COVID-19 PATIENTS WITH HYDROXYCHLOROQUINE TREATMENTConference abstract Published on 2022-03-012022-10-05 Journal: Journal of the American College of Cardiology [Category] 치료법, [키워드] COVID-19 hERG [DOI] 10.1016/S0735-1097(22)01046-4 [Article Type] Conference abstract
In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug AntitargetCardiovascular Medicine Published on 2021-05-042022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] abnormality absence Antitarget Antiviral antiviral drug antiviral treatments approach aromatic residue arrhythmia Atazanavir binding binding pockets binding site canonical Combination component computational modeling Contact COVID-19 cryo-EM structure determinant docked domain drug drugs ECG exploration Favipiravir FIVE hERG human ether-à-go-go–related gene in silico include inhibit Interaction less Lopinavir Lopinavir-ritonavir Pore potassium channel Potential reduced Remdesivir residue residues risk Ritonavir SARS-CoV-2 structure-function torsades de pointe Treatment [DOI] 10.3389/fcvm.2021.645172 PMC 바로가기 [Article Type] Cardiovascular Medicine
COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2Cardiovascular Medicine Published on 2020-05-052022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] addition arrhythmia caused challenge Combination Comorbidities concurrent COVID-19 COVID-19 pandemic Critical drug Drug safety drug-induced electrolyte imbalance hERG medication Patient potassium channel QT QT interval QTc receive risk Safe SARS-CoV-2 significantly synergistic the disease Therapeutic strategies treating [DOI] 10.3389/fcvm.2020.00085 PMC 바로가기 [Article Type] Cardiovascular Medicine