Whole blood samples for faster real-time PCR analysis of thrombophilic mutations in SARS-CoV-2 virus positive patientsArticle Published on 2022-07-292022-11-16 Journal: Physiological research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Blood blood sample carried carrier carriers Complete Concordance COVID-19 COVID-19 positive patients cycle threshold demonstrated DNA DNA extraction DNA molecule evaluated faster genotyping healthy heterozygote heterozygous homozygote homozygous incidence Laboratory Leiden median Modification Mutation mutations outpatients patients with COVID-19 PCR performed positive positive patient protocol provided real time Real-time PCR reported SARS-CoV-2 virus significant difference significantly subject thawing thrombosis Venous Thromboembolism Whole blood whole blood sample [DOI] 10.33549/physiolres.934883 PMC 바로가기
Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19Observational Study Published on 2022-05-172022-10-05 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] 임상, [키워드] acute lung injury adjusted Admission association Biochemistry Clinical outcome Comorbidities complications conducted consecutive patient covariate COVID-19 cumulative mortality Deiodinase evaluate Evidence Genotype heterozygote heterozygous homozygous median age Mortality multivariate logistic regression overall mortality Patient patients with COVID-19 phenotype phenotypical polymorphism polymorphism and COVID-19 prospective cohort study protective effect protective role pulmonary fibrosis ranged reduced risk reduction Severity Score stratified Thyroid Thyroid function tests Type type II deiodinase. while [DOI] 10.1210/clinem/dgac075 PMC 바로가기 [Article Type] Observational Study
Susceptibility of β-Thalassemia Heterozygotes to COVID-19Article Published on 2021-08-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] β-thalassemia Admission age Analysis association Atrial fibrillation Blood Characteristics chronic respiratory disease Clinical symptoms coronary disease coronavirus coronavirus disease COVID-19 COVID-19 severity diabetes disorder had no heterozygote Hospitalization hyperlipidemia hypertension ICU ICU admission ICU care intensive care Male sex Mortality observation participant Patient positive COVID-19 prevalent recruited reduced risk SARS-CoV-2 Sex single gene smoking status statistically significant susceptibility were assessed β-thalassemia [DOI] 10.3390/jcm10163645 PMC 바로가기 [Article Type] Article
Individual HLA-A, -B, -C , and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 SeverityImmunology Published on 2021-07-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] in silico prediction Antigen benefit courses COVID-19 COVID-19 severity determine effective element Factor functional Genotype heterozygote HLA HLA molecule HLA-A Immunogenetics in silico individual infected individuals investigated Major observé physicochemical predict predicted robust SARS-CoV-2 SARS-CoV-2 infections severity similarity spike glycoprotein T-cell epitope T-cell epitopes T-cell Response [DOI] 10.3389/fimmu.2021.698193 PMC 바로가기 [Article Type] Immunology
ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing RoleMedicine Published on 2021-01-212022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence ACE ACE gene ACE2 activity Angiotensin II assessment case-control study conducted counterbalance COVID-19 COVID-19 disease COVID-19 patient COVID19 COVID19 pneumonia Embolism expressed genetic risk factor genetic susceptibility heterozygote high risk homozygous I/D I/D polymorphism Infection investigated involved Italy MOST Naple Occurrence Patient patients with SARS-CoV-2 pilot study Pneumonia polymorphism Population Potential Prevalence pulmonary pulmonary angiography Pulmonary embolism retrospective role Severe COVID-19 pneumonia significantly higher significantly lower single-center statistically significant difference subject thromboembolic complication Thromboembolism unit [DOI] 10.3389/fmed.2020.631148 PMC 바로가기 [Article Type] Medicine
A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against COVID-19COVID-19 팬데믹에 대한 동남아시아의 관점: 헤모글로빈 E(HbE)-특성은 COVID-19에 대한 내성을 부여합니다Article Published on 2021-01-052022-09-11 Journal: Medical science monitor basic research [Category] 말라리아, 변종, 유전자 메커니즘, 치료제, [키워드] Against Alter Antiviral antiviral treatments appear Asian cellular change correlated country COVID-19 COVID-19 infection death death rate death rates deaths Decision-making Dengue dengue virus disease Factor Genetic genetic factors genetic mechanism heterozygote Hypothesis immune system Immunity incidence induce inhibiting interferon interferon response lead malaria mechanism miRNAs modulation multitude operative population prevalence populations positively correlated Prevalence Prevent protective effect Protein resistance SEA structural protein syndrome thalassemia variant Viral viral replication Viral resistance [DOI] 10.12659/MSMBR.929207 PMC 바로가기 [Article Type] Article
COVID-19: beta-thalassemia subjects immunised?Research article Published on 2020-09-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] analyzed Beta thalassemia beta-thalassemia contagious coronavirus correlated correlation COVID-19 COVID-19 infection COVID19 demonstrated disease Evolution Favipiravir heme hemoglobin heterozygote hypothese Immunity immunization Italian region Italy Multiple linear regression Novel coronavirus Pneumonia population prevalence prevalences Regression Research respiratory distress respiratory infectious disease Sardinia SARSCoV-2 Statistics subject virus [DOI] 10.1016/j.mehy.2020.109827 [Article Type] Research article
Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon카메룬에서 단순 말라리아에 영향을 받은 어린이의 플라스모디움 팔시파룸의 유전적 다양성과 유전적 프로필Research Published on 2020-03-182024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] GLURP protein heterozygote infection control Msp-1 MSP-2 Plasmodium [DOI] 10.1186/s12936-020-03161-4 PMC 바로가기 [Article Type] Research
The Prevalence of α-Thalassemia and Its Relation to Plasmodium falciparum Infection in Patients Presenting to Clinics in Two Distinct Ecological Zones in Ghanaarticle Published on 2016-12-312024-09-01 Journal: Hemoglobin [Category] 말라리아, [키워드] Coastal zone forest zone heterozygote homozygote Plasmodium falciparum thalassemia [Article Type] article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article