hierarchical clustering – Communicable Diseases Research

Exploring COVID-19 transmission patterns and key factors during epidemics caused by three major strains in Asia

COVID-19 전염 패턴 및 아시아에서 세 가지 주요 변종으로 인한 전염병 동안의 주요 요인 탐색

Article

Published on 2023-01-212023-07-10
Journal: Journal of theoretical biology [Category] COVID19(2023년),

Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent Mutations

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type
[DOI] 10.1128/spectrum.01219-22 PMC 바로가기

Computed tomography findings and prognosis in older COVID-19 patients

Research

Published on 2022-03-012022-10-27
Journal: BMC Geriatrics [Category] COVID-19,

[키워드] 95%CI Affect age calculated Chest CT chest CT scan chronic condition Cluster Clusters Computed tomography confounders consolidation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT finding CT findings enrolled GGO hazard ratio hierarchical clustering hospitalized COVID-19 patients identify implication independent Mortality multicenter multivariable model Old Older older patient older patients Oldest patients Pleural pleural effusion Pneumonia Prevalence prevalent Prognosis prognostic Prognostic marker reflect Result risk of death SARS-CoV-2 severity stratified supplementary material the patient tomography Validity was performed X-ray computed
[DOI] 10.1186/s12877-022-02837-7 PMC 바로가기 [Article Type] Research

Computed tomography findings and prognosis in older COVID-19 patients

Research

Published on 2022-03-012022-10-27
Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] 95%CI Affect age calculated Chest CT chest CT scan chronic condition Cluster Clusters Computed tomography confounders consolidation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT finding CT findings enrolled GGO hazard ratio hierarchical clustering hospitalized COVID-19 patients identify implication independent Mortality multicenter multivariable model Old Older older patient older patients Oldest patients Pleural pleural effusion Pneumonia Prevalence prevalent Prognosis prognostic Prognostic marker reflect Result risk of death SARS-CoV-2 severity stratified supplementary material the patient tomography Validity was performed X-ray computed
[DOI] 10.1186/s12877-022-02837-7 PMC 바로가기 [Article Type] Research

Genomic population structure associated with repeated escape of Salmonella enterica ATCC14028s from the laboratory into nature

실험실에서 자연으로의 살모넬라 enterica atcc14028의 반복 탈출과 관련된 게놈 집단 구조

Research Article

Published on 2021-09-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Americas Analysis ancestor Bacteria bacteriophage bacteriophages bioterrorism British Isle British Isles caused clade Cluster Clustering Contamination core gene core genome cross-contamination Culture database Divergence element escaped event Evolution experiment fitness followed by gene transfer Genetic genetic diversity genomic genomic sequence genomic sequencing greater growth media HGT Hierarchical hierarchical clustering horizontal gene Horizontal gene transfer Human humans implicated individual Infection infections Ireland isolate Isolation Laboratory lack less life lineages multiple laboratories multiple laboratory National natural selection Neutral physically Plasmid plasmids Quality control repeated Salmonella sequence SNP storage storage condition storage conditions strain Strains Taiwan transfer Type culture
[DOI] 10.1371/journal.pgen.1009820 PMC 바로가기 [Article Type] Research Article

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

Immunology

Published on 2021-09-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation activation pathway activity Admission Alternative pathway Analysis antigenic C1q Characteristics classical classical pathway clinical outcomes Cluster Coagulopathy Cohort collected complement Complement pathway component conducted contribute corticoid COVID-19 COVID-19 patient Critical died disease severity Effector mechanism endothelial injury excessive immune response exhibited Factor B favor functional heterogeneous hierarchical clustering Hospital admission Hospitalized hospitalized patient Hyperinflammatory ICU ICU care identify immune correlate Inflammatory intensive care lectin lectin pathway MBL Mortality Oxygen requirement oxygen support parameters pathway Patient performed pro-inflammatory cytokines proportion required Result resulting retrospective SARS-COV-2 infection severe COVID-19 single-center study the patient Treatment Trigger university ward was performed were measured
[DOI] 10.3389/fimmu.2021.742446 PMC 바로가기 [Article Type] Immunology

Platelet activation in critically ill COVID-19 patients

Research

Published on 2021-07-172022-10-28
Journal: Annals of Intensive Care [Category] COVID-19,

[키워드] Activation Admission Analysis Biomarker Cohort contribute COVID-19 COVID-19 patient COVID-19 severity Critical Critically ill Critically ill patient cross-sectional cutoff value death described disease severity driving dysregulation elevated enrichment analysis Evidence gene-expression GP1BB Hemostasis hierarchical clustering identify in-hospital mortality increased expression independent intubation marker mechanism Negative predictive value NPV outcomes Platelet platelet activation Platelets Positive predictive value PPBP PPV Predictive Primary hemostasis required Result ROC ROC Curve SELPLG severe coronavirus disease severity Specific supplementary material Thrombo-inflammation thrombotic event upregulated venous
[DOI] 10.1186/s13613-021-00899-1 PMC 바로가기 [Article Type] Research

Nine Months of COVID-19 Pandemic in Europe: A Comparative Time Series Analysis of Cases and Fatalities in 35 Countries

Article

Published on 2021-06-212022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS,

Genome-wide analysis of 10664 SARS-CoV-2 genomes to identify virus strains in 73 countries based on single nucleotide polymorphism

단일 염기 다형성을 기반으로 73개국의 바이러스 균주를 식별하기 위한 10664 SARS-CoV-2 게놈의 게놈 전체 분석

Article

Published on 2021-06-012022-09-11
Journal: Virus research [Category] SARS, 변종, 치료법,

[키워드] absence addition Analysis applied assessment Care Characteristics Cluster Clustering Clusters code Community Consensus country COVID-19 dataset determine environmental condition Evolution ExoN FIVE function genome-wide analysis Hamming distance Hierarchical hierarchical clustering identify linkage Measures Multiple Multiple sequence alignment mutated Non-synonymous Non-synonymous SNP NSP2 nucleocapsid nucleotide ORF3a performed polymorphism Protein provided Q57H Quantitative reported Research responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Sequence alignment shown Silhouette single nucleotide Single nucleotide polymorphism SNP SNPs stability structures synonymous SNP T85I tendency Vaccine Vaccine design Validity virus virus strain virus strains Visual website
[DOI] 10.1016/j.virusres.2021.198401 PMC 바로가기 [Article Type] Article

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2

Physiology

Published on 2021-05-312022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] ACE2 ACE2 expression acute lung injury acute respiratory syndrome addition aerosol aerosol exposure Aerosols Alter alteration Altered angiotensin-converting enzyme 2 BAL C57BL/6 CD1 CD177 CD4 CD4 T cells cell activation change changes in chronic component concern Conventional coronavirus coronavirus disease COVID-19 Defense demonstrated E-cigarette Epidemic form Gene Expression Gene expression analysis GSE hierarchical clustering higher risk Host host cells host response host susceptibility IgA immune Immunoglobulin immunomodulation impairment increase infect Infection Inflammation Inflammatory inflammatory disorder inflammatory pathways inhalation involved Lipidomics lung lung disorders Lung injury Lungs mice moderate monocyte neutrophil neutrophil activation Neutrophils occurred pathogen profile receptor reduced reductions in response RNAseq SARS-CoV-2 SARS-COV-2 infection smoker smoking state suggested susceptibility upregulation vaping
[DOI] 10.3389/fphys.2021.649604 PMC 바로가기 [Article Type] Physiology