The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 MiceArticle Published on 2024-01-132024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] cerebrum high mortality rate SARS-CoV-2 Syrian hamsters viral distribution and duplication [DOI] 10.3390/ijms25020997 PMC 바로가기 [Article Type] Article
The role of kidney injury biomarkers in COVID-19COVID-19에서 신장 손상 바이오마커의 역할Review Published on 2022-12-012022-09-11 Journal: Renal failure [Category] 바이오마커, [키워드] Acute kidney injury AKI Biomarker Biomarkers clinical settings complex coronavirus coronavirus disease COVID-19 death demonstrated Diagnosis disease Disease progression early diagnosis global pandemic high mortality rate hospital IGFBP7 IL-18 IMPROVE independent risk factor Intervention kidney Kidney injury molecular molecular mechanism molecular mechanisms outbreak outcomes Patient patients with COVID-19 Research Sepsis suPAR unique [DOI] 10.1080/0886022X.2022.2107544 PMC 바로가기 [Article Type] Review
Mortality among hospitalized COVID-19 patients during surges of SARS-CoV-2 alpha (B.1.1.7) and delta (B.1.617.2) variantsArticle Published on 2022-11-072022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] 95% CI Admission Alpha B.1.1.7 B.1.617.2 conducted contributed COVID-19 death Delta died evaluate Factor high mortality rate higher risk hospital hospitalizations hospitalized COVID-19 patient hospitalized patient hospitalized patients ICU Iran lack Nurse nutritional status occurred Patient patients with COVID-19 physician proportion risk of COVID-19 SARS-CoV-2 significantly significantly higher Tehran variant [DOI] 10.1038/s41598-022-23312-8 PMC 바로가기
A case of acquired hemophilia A and bullous pemphigoid following SARS-CoV-2 mRNA vaccinationArticle Published on 2022-09-012022-11-15 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 진단, [키워드] Acquired acquired hemophilia Acquired hemophilia A activated AHA autoantibody Autoimmunity bleeding Blister bullous bullous pemphigoid Characteristics Diagnosis environmental factor epithelial FVIII Genetic hemophilia Hemorrhagic high mortality rate immune tolerance inhibitor Isolated membrane Moderna mRNA mRNA vaccination mRNA vaccine pathophysiology pemphigoid rare disease recent reported resulting SARS-CoV-2 supported vaccination zone [DOI] 10.1016/j.jfma.2022.02.017 PMC 바로가기
Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approachArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19 [DOI] 10.3389/fimmu.2022.975848 PMC 바로가기
Defibrotide Therapy for SARS-CoV-2 ARDSClinical Trial Published on 2022-08-012022-10-04 Journal: Chest [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI Administered adverse event age all-cause mortality antiinflammatory Antithrombotic ARDS baseline bleeding Course COVID-19 D-dimer D-dimer level Day decrease defibrotide defibrotide. died dysregulation Endothelial dysfunction fibrinolytic Hemorrhagic high mortality rate initial limit management mechanical ventilation median median age occurred Older Open-label outcome parameter participant pathway Patient patient population patients died polymerase chain positive pulmonary disease Radiographic receiving reported Respiratory function Safe SARS-CoV-2 SARS-CoV-2 ARDS serum severe SARS-CoV-2 single-center survived therapy thrombotic complication Tolerability tolerable treated Trial vasopressor support [DOI] 10.1016/j.chest.2022.03.046 PMC 바로가기 [Article Type] Clinical Trial
Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics studyD614G 점 돌연변이에 따른 SARS-CoV-2 스파이크 단백질의 분자 특성에 대한 통찰력, 분자 역학 연구Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] addition Amino acid amino acid sequence asymmetric bioinformatics catastrophic changes in Characteristics D614G D614G mutation Effect effective high mortality rate insight molecular molecular dynamics mutant Mutation negative charge Point mutation polar positive Positive Charge Protein public health Receptor binding residue risk factor SARS-CoV-2 SARS-CoV-2 spike protein secondary structure sequence spike stability Substitution tertiary structure the SARS-CoV-2 Treatment virus [DOI] 10.1080/07391102.2021.1872418 PMC 바로가기 [Article Type] Article
Multiple biventricular thrombi in a patient with alcoholic cardiomyopathy and COVID-19: A tragic association in a deadly pandemicCase report Published on 2022-08-012022-10-05 Journal: Journal of Cardiology Cases [Category] 변종, [키워드] Activation alcohol association Cardiomyopathy condition coronavirus disease Coronavirus disease 2019 COVID-19 dilated cardiomyopathy dysfunction high mortality rate hypercoagulable intracardiac Intracardiac thrombus learning manifestation Multiple myocardial damage Myocardial infarction occur pandemic Patient produced risk Significant systemic inflammation thrombosis Thrombus unique variety [DOI] 10.1016/j.jccase.2022.03.019 [Article Type] Case report
Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19COVID-19의 역할을 포함한 횡문근 융해 유발 AKI(RIAKI)Review Published on 2022-07-262022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration AKI aspartate Aspartate aminotransferase AST bloodstream caused Cell combination therapy Complication contribute coronavirus Course COVID-19 COVID-19 disease creatine creatine kinase damage defined develop Diagnosis disease drugs escape Factors FIVE Fluid resuscitation furosemide high mortality rate in some Including Lactate lactate dehydrogenase LDH life-threatening limit mannitol many cases marker muscle pain Myoglobin occur Pain Patient patients Potassium renal renal replacement therapy replacement therapy required respiratory rhabdomyolysis role RRT SARS-CoV-2 serious complication serum severe acute respiratory syndrome Coronavirus Side effect Side effects sodium sodium bicarbonate statin Striated muscle therapeutic interventions therapy Treatment uridine [DOI] 10.3390/ijms23158215 PMC 바로가기 [Article Type] Review
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article