Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Affect Alter antibody Antibody Response Antigen antigen exposure antigenic B.1.1.529 boost chronic conditions chronic infection clinical history Cohort COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibody cross-reactivity defined described detectable Diseases epitope glycoprotein healthy high mutation rate highly antigenic immune response immunogenic individual mechanism mutations naïve individual neurological omicron overlapped Pathogens resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein serum antibody severe COVID-19 specificity Spike protein Subsequent infection target the antibody response understanding vaccination variants of SARS-CoV-2 Viral antigen virus viruses [DOI] 10.1038/s41598-022-20849-6 PMC 바로가기
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemicArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] activate administration antigen presenting cell booster Course dendritic dendritic cell dendritic cells Developing Diseases effective Effectiveness eliminating finding high mutation rate immune system Immunity Immunotherapy induce Infection pandemic pathogenesis of SARS-CoV-2 Prevent problems SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines T cell T cells the disease Vaccine vaccine approach vaccine candidate virus [DOI] 10.3389/fimmu.2022.989685 PMC 바로가기
Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution DynamicsRBD 오미크론 돌연변이 및 SARS-CoV-2 진화 역학과 관련된 면역 탈출Review Published on 2022-07-222022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect appearance bioinformatics COVID-19 COVID-19 pandemic described Dynamics escape Evolution explained Features Genome high affinity high mutation rate Host immune Immune escape Lineage Mutation mutation rate natural immunity omicron pathogenicity Protein RBD RBD mutations receptor SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strains serotype Spike protein the Spike therapeutic therapeutic agent therapeutic agents Transmissibility Vaccine Vaccine development variant virus [DOI] 10.3390/v14081603 PMC 바로가기 [Article Type] Review
Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans숙주-게놈 유사성은 SARS-CoV-2의 인간 적응을 특징짓는다Article Published on 2022-07-122022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptability Alpha Analysis Beta coronavirus correlation dataset Delta delta variant evade evade immunity FIVE Frame Gamma Genome genomes help HGS high mutation rate highest Host host genome host genome similarity host innate immunity Human IFN-β immune system Immunity in vivo Indicator Innate immunity Interaction lowest mechanism Mutation mutation rate omicron Omicron variants Open reading frame ORF populations puzzle SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus shown signaling pathway similarity strain suppression variant variants viral genomes [DOI] 10.3390/biom12070972 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling중증 급성 호흡기 증후군 코로나바이러스 2 ORF8 단백질은 HSP90B1 신호 전달을 표적으로 하여 I형 인터페론 생산을 억제합니다Article Published on 2022-05-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid Antiviral caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 exhibit explanation function Genotype genotypes global pandemic high mutation rate high mutation rates HSP90B1 IFN-I IFN-β immune evasion Immune suppression implication individual induce inhibit inhibitory effect interact interferon interferon response investigated IRF3 ISG15 leucine MDA5 mechanism Mutation no difference nuclear translocation ORF8 ORF8 protein pandemic pathogenic pathway poly(I:C) Production Protein provide reported respiratory RIG-I SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus signaling pathway strain suppress targeting the SARS-CoV-2 Treatment Type type I interferon variant [DOI] 10.3389/fcimb.2022.899546 PMC 바로가기 [Article Type] Article
SARS-CoV-2’s high rate of genetic mutation under immune selective pressure: from oropharyngeal B.1.1.7 to intrapulmonary B.1.533 in a vaccinated patient면역 선택 압력 하에서 SARS-CoV-2의 높은 유전 돌연변이 비율: 백신 접종 환자의 구강인두 B.1.1.7에서 폐내 B.1.533으로Case Reports Published on 2022-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affected analyzed B.1.1.7 B.1.1.7 lineage bioinformatic analysis Case report collected complex COVID-19 dose Genetic high mutation rate immune Intra-Host Mutations intrapulmonary LAMP Lineage lineages lung Mutation mutation rate nasal swabs nasopharyngeal nasopharyngeal sample Nasopharyngeal samples next generation sequencing NGS observation Oropharyngeal Patient PCR polymorphism positive Post-vaccine Post-vaccine. Postmortem reverse transcription RT-LAMP SARS-CoV-2 selective single-nucleotide Single-nucleotide polymorphisms SNPs suggested survival tested the disease to define vaccination Viral Viral RNA viral RNAs virus [DOI] 10.1016/j.ijid.2022.02.044 PMC 바로가기 [Article Type] Case Reports
Both simulation and sequencing data reveal coinfections with multiple SARS-CoV-2 variants in the COVID-19 pandemicResearch article Published on 2022-03-182022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 변종, 유전자 메커니즘, [키워드] accumulations analyses average Betacoronavirus Coinfection index collected COVID-19 case COVID-19 pandemic COVID-19 patient datasets demonstrated GISAID database heterozygous Heterozygous single-nucleotide polymorphisms high mutation rate linear relationship loci nanopore sequencing patients performed polymorphism reported RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variant coinfection sequencing data single-nucleotide single-stranded SNP SNV Transmissibility transmission route Vaccine variant variants Viral transmission simulation [DOI] 10.1016/j.csbj.2022.03.011 [Article Type] Research article
First detection of Hedgehog coronavirus 1 in PolandArticle Published on 2022-02-112022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] age Analysis betacoronaviruses China clinical status Coronaviral coronavirus CoV CoVs Europe European country Evidence excluded France Gender Germany hedgehog high mutation rate Host Italy kidney lung majority management Microbiology Molecular biology Pathogens Poland recombine rectal swab rehabilitation RNA strain Transmission Viral RNA virus viruses [DOI] 10.1038/s41598-022-06432-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 Serological and Biomolecular Analyses among Companion Animals in Campania Region (2020–2021)Communication Published on 2022-01-242022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] accelerate ACE2 affected animal animal hosts anti-N antibody Campania cat cellular receptor collected COVID-19 described dog Evolution FIVE high mutation rate moderate neutralizing antibody titers no difference Prevalence real-time RT-PCR Region reservoir risk RT-PCR SARS-CoV-2 SARS-COV-2 infection serological serology seropositive significantly Surveillance susceptible tested Transmission transmission of SARS-CoV-2 variants Viral RNA viral strains wild animals with COVID-19 [DOI] 10.3390/microorganisms10020263 PMC 바로가기 [Article Type] Communication