SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmissionArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration antibody approved Booster vaccine Combination Community consequence current Delta delta variant diagnosed dominant dominant variant Efficacy Evolution FDA higher infectivity human lung tissue immune Immune escape immune evasion Immunity immunocompromised individual IMPROVE Infection less monoclonal monoclonal antibodies Mutation mutations neutralising omicron Omicron variant other variant Protein public health recombination event reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variants severity Sotrovimab spike Spread syncytia formation the SARS-CoV-2 therapeutic use Transmission Vaccine variant variants of SARS-CoV-2 Wuhan-Hu-1 zoonotic [DOI] 10.1002/rmv.2381 PMC 바로가기
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
Nanomechanical analysis of SARS-CoV-2 variants and predictions of infectiousness and lethalityArticle Published on 2022-08-102022-11-16 Journal: Soft matter [Category] SARS, 변종, [키워드] Alpha variant Analysis approach B.1.351 B.1.617.2 Beta cause circulation COVID-19 D614G D614G mutation delta variant Effect epidemiological estimate explain higher infectivity interactions less Lineage Lineage B.1.1.7 molecular mutate Mutation offer pathogen pathway predict predicted Predictive Prevalence SARS-CoV-2 variant spike mutation Spike protein Spread strain variant variants virus virus spike protein viruses [DOI] 10.1039/d1sm01181b PMC 바로가기
An intranasal ASO therapeutic targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 비강내 ASO 치료제Article Published on 2022-08-032022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] administration antibody immunity Antisense oligonucleotide ASO binding complement conserved coronavirus COVID-19 COVID-19 pandemic Daily decrease disrupt Efficacy effort evade help higher infectivity human cells identify in vitro in vivo infected individuals Inhaled intranasal leader sequence lung Lungs mice new SARS-CoV-2 Non-invasive nucleic acid Pandemics Prevent preventing infection Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence severity of COVID-19 suppresse tested the SARS-CoV-2 therapeutic Therapeutic approach therapeutic strategy therapeutic targeting tide Transmission turn vaccination Vaccine variant Viral viral replication Viral RNA [DOI] 10.1038/s41467-022-32216-0 PMC 바로가기 [Article Type] Article
Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variantSARS-CoV-2 Omicron 변이체의 스파이크 단백질 N-말단 및 수용체 결합 도메인의 구조적 특성에 대한 통찰력Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility ACE2 addition Analysis antibody B.1.1.529 BA.1) binding binding domain binding efficiency changes in computational analysis COVID-19 COVID-19 vaccines Effect Epitopes evaluated free energy glycan glycans higher infectivity insight Interaction mAb molecular dynamics molecular dynamics simulations Mutation N-terminal N-terminal domain N-terminal domain (NTD) Neutralizing NTD NTDs omicron Omicron (B.1.1.529 Omicron variant performed Protein provide raised RBD RBD domain RBDs Receptor binding domain receptor binding domain (RBD) reduce reducing residue SARS-CoV-2 specific antibodies Spike protein stability the RBD the SARS-CoV-2 the spike protein variant variant of SARS-CoV-2 Wuhan [DOI] 10.1016/j.compbiomed.2022.105735 PMC 바로가기 [Article Type] Article
Associations of Clinical Factors and Blood Groups With the Severity of COVID-19 Infection in Makkah City, Saudi ArabiaObservational Study Published on 2022-06-212022-10-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] 임상, [키워드] ABO ABO blood groups association Asthma Blood Blood Group chronic kidney diseases city clinical Clinical characteristics clinical factor confirmed COVID-19 case congestive heart failure correlation cough COVID-19 COVID-19 infection COVID-19 patient cross-sectional Deceased Diabetes Mellitus diagnosed disease distress distribution expected Factor Fever Frequency group higher infectivity Hospitalized hospitalized COVID-19 patient hypertension infected patient Infection Kingdom Makkah material medical record Ministry of Health Mortality no significant difference Patient patients PCR phenotype Pneumonia positive positive PCR Prevalence Respiratory failure retrieved Rh blood groups Risk factors risk of death Saudi Arabia severity of COVID-19 significantly increased significantly lower specialist Symptom Symptoms syndrome tested Western region with COVID-19 [DOI] 10.3389/fcimb.2022.870096 PMC 바로가기 [Article Type] Observational Study
Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation응급의사를 위한 COVID-19 임상 업데이트: 발표 및 평가Review Published on 2022-04-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assist B.1.1.529 B.1.617.2 cardiovascular caused changes in Chest radiography clinical Clinicians Comorbidities Complication Computed tomography coronavirus coronavirus disease Coronavirus-2019 COVID COVID-19 Critically ill Delta delta variant disease emergency department end-organ Extrapulmonary Fever Gastrointestinal higher infectivity imaging include index infections Injury Lineage mild symptoms morbidity and mortality neurologic NEWS2 Older omicron Omicron variant outcomes pandemic Patient presentation presenting symptoms progressed proportion provide respiratory respiratory symptoms risk score SARS-CoV-2 several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase those with comorbidities Ultrasound upper upper respiratory symptoms variant while [DOI] 10.1016/j.ajem.2022.01.028 PMC 바로가기 [Article Type] Review
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escapeSARS-CoV-2 스파이크 E156G/Δ157-158 돌연변이는 증가된 감염성과 면역 탈출에 기여합니다Article Published on 2022-03-162022-09-11 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, [키워드] addition B.1.617 Breakthrough infection breakthrough infections changes in circulating coding region Combination contribute contributed D614G exhibited functional higher infectivity Immune escape Infection introduced L452R mutant Mutation mutations N-terminal domain neutralization neutralized NTD plasma Pseudotyped viruses raise reduced reported SARS-CoV-2 spike SARS-CoV-2 variant screened sensitivity sequence sequences spike gene spike mutation spike mutations spike-pseudotyped virus spike-pseudotyped viruses T19R USA vaccine-induced antibodies viral particle Viral particles [DOI] 10.26508/lsa.202201415 PMC 바로가기 [Article Type] Article
Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2SARS-CoV-2 포획을 위한 나노바디 기능화 셀룰로오스Article Published on 2022-03-082022-09-11 Journal: Applied and Environmental Microbiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bacteria binding biological fluid Blood Cellulose cellulose binding domain cellulose binding protein complement complementary complex coronavirus COVID-19 COVID-19 pandemic cytokine Cytokines D614G variant diagnostics domain Efficiency effort exhibited filtration fluids fungi fusion protein help higher infectivity immobilization IMPROVE infected individuals intrinsic lockdowns mandatory mitigate nanobody porous preventative measures proof proof of concept provided pseudoviruses Receptor-binding domain reducing removal SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses sensitivities shown substrate the receptor-binding domain Therapeutic strategies utility vaccination Vaccinations Viral detection Viral load viral spread Viral transmission virus viruses wild type [DOI] 10.1128/aem.02303-21 PMC 바로가기 [Article Type] Article