ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental InfectionSARS-CoV-2 태반 감염에 대한 항레트로바이러스 요법에 노출된 HIV 양성 임신의 태반에서 ACE2, TMPRSS2 및 L-SIGN 발현Article Published on 2021-12-082022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus AIDS angiotensin Antiretroviral therapy ART binding Black race Chain Reaction coexpressed contribute coronavirus COVID-19 detrimental expression female groups HIV HIV infection HIV protease inhibitors HIV-uninfected hyperinflammation infant sex L-SIGN lower expression mRNA level mRNA levels Neonate Placenta placental polymerase chain polymerase chain reaction pregnant women priming protease Protease inhibitor protease TMPRSS2 Quantitative quantitative polymerase chain reaction race receptor receptor ACE2 reduced Renin renin-angiotensin system SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SIGN significantly significantly higher Spike protein susceptibility the spike protein TMPRSS2 TMPRSS2 level TMPRSS2 levels viral entry with HIV women [DOI] 10.1093/infdis/jiab166 PMC 바로가기 [Article Type] Article
Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for the treatment of SARS-CoV-2 infection and COVID-19SARS-CoV-2 감염 및 COVID-19 치료를 위한 HIV 프로테아제 억제제 및 뉴클레오타이드 RNA 폴리머라제 억제제 재배치Review Published on 2021-03-042022-08-31 Journal: European Journal of Clinical Pharmacology [Category] SARS, 신약개발, 임상, 치료제, [키워드] addition antiretroviral Antiviral treatment approved approved drug candidate Candidates Clinical studies clinical study clinical trial clinical trials clinician Cobicistat compounds COVID-19 darunavir darunavir/cobicistat drug drugs evaluate evaluated Favipiravir followed by high variability HIV protease inhibitor HIV protease inhibitors Hospitalization indications inhibitors lack Lopinavir Lopinavir/ritonavir MERS Mortality pandemic Prevalence Protease inhibitor protease inhibitors question Remdesivir repositioning Repositioning drugs Research Result Ritonavir RNA polymerase RNA polymerase inhibitor RNA polymerase inhibitors RNA virus SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pandemic single-stranded RNA virus sofosbuvir Study design Taking target tenofovir the SARS-CoV-2 therapeutic options Therapeutics Treatment treatment of COVID-19 Vaccine [DOI] 10.1007/s00228-021-03108-x PMC 바로가기 [Article Type] Review
Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main proteaseResearch Published on 2020-11-262022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] acting acute respiratory syndrome Antiviral assays carried caused Cell culture cell culture experiment Concentration coronavirus COVID-19 cytotoxicity drug effective Efficacy enzymatic assay GFP HIV HIV protease inhibitor HIV protease inhibitors in vitro In vitro assay in-depth analysis Infection inhibit inhibition Inhibition profiling inhibitor inhibitory effect Lopinavir M pro mechanism of action methodology molecular much higher pandemic plasma protease reported reporter required Result Ritonavir SARS-CoV-2 targeting therapy while [DOI] 10.1186/s12985-020-01457-0 PMC 바로가기 [Article Type] Research
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전Article Published on 2020-08-012022-09-11 Journal: Human reproduction (Oxford, England) [Category] Coronavirus, 비임상, [키워드] Activation Administered Affect age alteration Analysis Angiogenesis animal model Antiretroviral therapy approval Biomarker Biomarkers biopsy birth outcomes breath cART cause caution Cell Cell culture cells chance clinical implications clinical trial clinical trials clinically co-culture Combination complement Complement activation conception contributing to correlation COVID-19 COVID-19 pandemic Culture culture system current darunavir decidualization decrease drug candidate Drug safety dysregulation early pregnancies early pregnancy early stage early stages Effects Efficacy ELISA evaluate evaluated event Evidence evidence of Ex vivo experimental models expression Factor Factors female first trimester flow cytometry for inclusion foundation funding gestational age Health care Health care worker health care workers healthy highest highlight HIV HIV infection HIV protease inhibitor HIV protease inhibitors immune cell population immune cell populations immune dysregulation Immunohistochemical analysis immunohistochemistry impair impairment implication in vitro in vivo include Inflammation initiated lack leads Lopinavir Luminex assay Lye matter maturation mechanism media mice Migration modify mouse natural killer Natural killer cells offered once daily outcome outcomes Participation placental placentation potential mechanism pregnancies Pregnancy pregnant women prophylactically protease PROTECT quantified reduced regimen regulate reported reproductive resource Respiratory disease sacrifice Safe selective specific effect specific effects spiral spiral artery spiral artery remodeling STAT3 Stephen Support supported TANK termination of pregnancy therapeutic potential Think tank tissue transcription factor Transgender Treatment Trial trophoblast trophoblasts uterine uterine natural killer cells. Vascular viability was measured was obtained was used water were used with HIV women [DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article
Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactionsarticle Published on 2019-12-312024-09-01 Journal: Current Topics in Medicinal Chemistry [Category] 말라리아, [키워드] Antimalarials HIV protease inhibitors malaria P. falciparum P. vivax drug targets Plasmepsin [Article Type] article