In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic virusesArticle Published on 2024-02-052024-09-05 Journal: Virus Research [Category] update2024, [키워드] broad-spectrum antiviral COVID-19 HMOX1 MIT-001 NqO1 ROS [DOI] 10.1016/j.virusres.2024.199325 PMC 바로가기 [Article Type] Article
Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19Article Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, 치료제, [키워드] ACTA1 aggressiveness ALB analyses Analysis analyzed Anti-inflammatory anti-inflammatory action Antiviral effect binding activity bioinformatics Biological functions chemokine Coronavirus disease 2019 COVID-19 cytokine production digestive system Effect effective enrichment analysis epithelial evaluate HCC HCC patient HCC patients help hepatocellular Hepatocellular carcinoma HMOX1 identifying immune response immunomodulatory involved malignancy mechanism molecular molecular docking molecular mechanism network pharmacology pandemic performed pharmacological target poor prognosis Predictive Prognosis prognostic public health RBP4 Regulation risk Seven signaling pathway target gene Target genes therapeutic effect TLR4 TTR Vitamin D with COVID-19 [DOI] 10.3389/fimmu.2022.985781 PMC 바로가기
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개Article Published on 2022-07-162022-09-11 Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘, [키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease [DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article
SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysisSARS-CoV-2 잠재적 약물, 약물 표적 및 바이오마커: 바이러스-숙주 상호작용 네트워크 기반 분석Article Published on 2022-07-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 임상, 치료제, [키워드] Amiodarone Analysis anthracyclines Antibiotics Antiviral antiviral agent Biomarker Blood CDK1 cell cycle CENPF CIT Complete COVID-19 cytarabine daily living diagnostic biomarker Diagnostic biomarkers Differentially expressed genes digitoxin Doxorubicin drug drug target drugs Enhancing enrichment ERG example expression FDA-approved drug FDA-approved drugs FLUOROURACIL gemcitabine global pandemic HMOX1 host cell hydroxyurea identify Infection inhibitors Interaction less mir-93 mitotic MYB omicron Omicron variant pathway Pathways performed Probability prognostic biomarker repositioning retrieved RRM2 SARS-CoV-2 sotalol suggested targets the disease therapeutic TOP2A transcriptomic transmission rate Treatment variant variants viral-host interaction virus [DOI] 10.1038/s41598-022-15898-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular DockingMedicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 binding ADRB2 Against Analysis anti-SARS-CoV-2 baicalein China Chinese Chinese medicine component Compound COVID-19 cross database differentially expressed gene enrichment analysis expression FOS Frequency Gene ontology GeneCards highest HMOX1 Hydrogen bond hydrophobic ICAM1 identify IL6 immune immune function immune-related gene immunization ingredient Interaction JUN KEGG Kyoto lung adenocarcinoma molecular docking molecular target National Health Commission network network pharmacology NFKBIA NHC nine objective Occurrence overlapped overlapping performed Pharmacology platform positively correlated Potential potential mechanism prescription Result screened selected Stat1 target target gene TCM TCMSP therapeutic target UniProt viral transcription was used were used with COVID-19 [DOI] 10.3389/fmed.2021.813119 PMC 바로가기 [Article Type] Medicine
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin국소 차아염소산(HOCl)은 UV에 노출된 SKH-1 고위험 마우스 피부에서 염증성 유전자 발현 및 종양 발생 진행을 차단합니다Article Published on 2021-09-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, [키워드] addition Analysis AP-1 atopic dermatitis bioluminescent block blocked Cancer Carcinogenesis clinical evidence combinations condition consequence COVID-19 pandemic drinking water elicited environmental exposure example exposure to finding Gene Expression Gene expression analysis high risk HMOX1 HOCl hypochlorous acid Il19 Immunohistochemical analysis Inflammation Inflammatory inflammatory signaling investigated luciferase mice mimicking modulation molecular murine model NOS2 observation oxidative stress oxidizing Pathway-focused gene expression profiling performed progression psoriasis PTGS2 public health Radiation reconstructed released skin skin cancer Solar Solar UV radiation. Srxn1 Stress stress response subsequent Support suppressed suppression Swimming pool therapeutic therapeutic intervention These data TLR4 Topic topical transgenic ultraviolet water [DOI] 10.1016/j.redox.2021.102042 PMC 바로가기 [Article Type] Article
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-CoronavirusesSARS-CoV-2 및 Pan β-Coronavirus에 대한 향신료의 생물학적 활성 성분의 잠재적 면역 조절 특성Cellular and Infection Microbiology Published on 2021-08-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alleviate Anti-inflammatory antioxidant antioxidants Antiviral antiviral properties bioactive components CCL2 cellular pathway cellular pathways chemokine Clinical outcome component contributing to coronavirus COVID-19 COVID-19 severity diet Effect elevated erythroid Health Health crisis Health Organization highlight HMOX1 homeostasis host cell host cell factor Host immune response host immune responses hypercytokinemia hyperinflammation IL6 IL8 immune responses Immunity inhibiting Interleukins lethality mediators modulate Multiorgan dysfunction Nrf2 nuclear oxidative oxidative stress Pan pathway Pneumonia Potential Prevent pro-inflammatory pro-inflammatory mediator pro-inflammatory mediators promise property PROTECT protective immunity respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus spice spices sustained systemic inflammation tissue damage TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variation World Health Organization β-Coronaviruses [DOI] 10.3389/fcimb.2021.729622 PMC 바로가기 [Article Type] Cellular and Infection Microbiology