A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif Research Published on 2022-08-262022-10-05 Journal: Nature Communications [Category] 변종, [키워드] C-terminal characteristic complex conserved demonstrated enzyme genomic Genomic analysis homolog homologue Lyase motif Occurrence oxidative decarboxylation pathway peptide posttranslational modifications residue responsible subsequent synthesised [DOI] 10.1038/s41467-022-32774-3 [Article Type] Research
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19Article Published on 2022-08-112022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Affect AIFM1 antibody Antigen appear assisted ventilation Autoimmunity Brainstem Control controls Course COVID-19 patient COVID-19 patients DAB1 determine diagnostic Disabled Economy elevated Encephalitis epitope Epitopes finding foundation funding Germany Greifswald group help homolog hypothesised IgG IgG and IgM IgG level IgM implicated in both groups initiative intensive care Invasion long-COVID marker Medicine Microarray Mild Occurrence pathogenic pathway Patient peptide epitope predicted responsible SARS-CoV-2 serum severe disease severely ill patient significantly state Support SURF1 the disease therapeutic understanding university unlikely with COVID-19 [DOI] 10.1016/j.ebiom.2022.104211 [Article Type] Article
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteinsCOVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다Article Published on 2022-07-052022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccine response vaccine-induced antibody response widespread [DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article
Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research염증성 질환 치료를 위한 음파 고슴도치 경로: 향후 연구를 위한 의미 및 기회Editorial Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute myeloid leukemia Airway inflammation allergy Arthritis Asthma atopic dermatitis Autoimmune diseases Basal cell basal cell carcinoma Breast cancer Cancer cancer development cancers Cell cellular response component conserved COVID-19 Crohn's disease different diseases disease drugs dysregulation embryogenesis Factors glioma homolog Host human body immune dysregulation immune response immune system evasion implication Infection infections Inflammation Inflammation mediators Inflammatory Influenza inhibit investigated involved lung carcinoma malignancies mechanism medulloblastoma Mutation Pancreatic cancer pathogen pathogen-mediated pathogenic pathway progression receptor receptor inhibitor Research rheumatoid arthritis SARS-CoV-2 viruses shifting signaling pathway targets Therapeutic approach therapeutic strategy tissue homeostasis transcriptional treat Treatment tumors [DOI] 10.1136/jitc-2021-004397 PMC 바로가기 [Article Type] Editorial
Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosisCaspase-4/11은 염증 및 면역 혈전증을 촉진하여 SARS-CoV-2 감염의 질병 중증도를 악화시킵니다.Article Published on 2022-05-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated acute respiratory syndrome Blood CASP4 caspase caspase-11 Coagulopathy coronavirus CXCL1 detrimental disease severity downstream drug target effective endothelial damage exacerbate expressed expression Factor functions gene signature GSDMD Health homolog humans IL-6 immunothrombosis Infection Inflammation Inflammatory inflammatory mediator Innate immunity less lung Lung pathology Lungs maintain marker mice molecular target neutrophil new treatment strategy pathway promote protein level reduced SARS-COV-2 infection SARS–CoV-2 severe COVID-19 severity targeting therapeutic thrombosis transcription factor transcriptomics Treatment up-regulated Vascular vessel viral titer von Willebrand factor weight loss wild-type [DOI] 10.1073/pnas.2202012119 PMC 바로가기 [Article Type] Article
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation분자 도킹 시뮬레이션을 사용한 SARS-CoV-2의 잠재적 억제제로서의 천연물 스크리닝Article Published on 2022-03-012022-09-11 Journal: Chinese journal of integrative medicine [Category] SARS, 치료제, [키워드] 3CL 3CL pro ABL1 acting activated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme anti-SARS-CoV-2 berbamine betulinic acid binding affinity calcineurin carried Cepharanthine chymotrypsin Chymotrypsin-like protease Compound compounds coronavirus derivative drug emodin enzyme glucogallin homolog human coronaviruses in-silico juglanin leukemia molecular molecular docking molecular docking studies Molecular docking study MOST murine natural natural products-derived anti-SARS-CoV-2 candidates NFAT non-structural protein nonstructural proteins nsp10 nsp13 nsp14 Nsp15 Other Papain Papain-like protease performed Potential product protease Protein quercetin RdRP receptor RNA-dependent RNA polymerase S protein SARS-CoV-2 screened Screening Serine serine 2 severe acute respiratory syndrome Coronavirus Simulation spike glycoprotein structural proteins T-cell T-cells tanshinone tanshinone I target target protein target proteins these compound these compounds transmembrane [DOI] 10.1007/s11655-021-3504-5 PMC 바로가기 [Article Type] Article
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis5-요오도투베르시딘은 SARS-CoV-2 RNA 합성을 억제합니다Article Published on 2022-02-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 6-Thio-dG absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine ADK antiviral activity antiviral drugs caused Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deoxyguanosine drug exhibited Fludarabine Fludarabine Phosphate functional highlight homolog humans Infectious disease inhibit inhibiting inhibitors inhibitory activity life cycle Novel coronavirus nucleotide nucleotide analogs pandemic phosphate presenting RdRP RdRp inhibitors RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA screened severe acute respiratory syndrome Coronavirus urgency viral life cycle [DOI] 10.1016/j.antiviral.2022.105254 PMC 바로가기 [Article Type] Article
Re-purposing of hepatitis C virus FDA approved direct acting antivirals as potential SARS-CoV-2 protease inhibitorsResearch article Published on 2022-02-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] acting Analysis Antiviral approach approved binding binding affinity binding energy binding site caused clinical trial correlation COVID-19 Cys145 Direct Direct Acting Antivirals (DAAs) docked docking drug drug re-purposing enzyme examined exhibiting FDA food Glu166 HCV hepatitis C hepatitis C virus HIS163 His41 homolog IC50 identify in silico inhibitor investigated MPro Mpro protease New coronavirus protease protease inhibitors provide Replication reported Repurposed drugs SARS-CoV-2 SARS-CoV-2 protease second Structure susceptible the SARS-CoV-2 therapeutic THR26 Treatment Vaccine viral infection worldwide pandemic Wuhan, China [DOI] 10.1016/j.molstruc.2021.131920 [Article Type] Research article
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?원발성 갑상선 육종에서 SARS-CoV-2 검출: 우연인가 상호작용인가?Case Reports Published on 2022-01-052022-09-10 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] analyzed Chain Reaction COVID-19 epidemic cytology cytopathic cytoplasmic demonstrated diagnosed diffuse downregulation evaluated expression homolog Hypothesis immunological MDM2 mouse neoplastic neoplastic cells overexpression p53 pathway Patient polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved Sarcoma SARS-CoV-2 SARS-CoV-2 detection sequence specimen Spread Subacute thyroiditis synergistic Thyroid thyroid dysfunction Thyroiditis Tumor tumor cell tumor cells tumor growth turn Vero E6 Vero E6 cell VERO E6 cells Viral viral particle Viral particles viral persistence Whole-genome sequence [DOI] 10.1007/s40618-021-01722-1 PMC 바로가기 [Article Type] Case Reports