Whole blood samples for faster real-time PCR analysis of thrombophilic mutations in SARS-CoV-2 virus positive patientsArticle Published on 2022-07-292022-11-16 Journal: Physiological research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Blood blood sample carried carrier carriers Complete Concordance COVID-19 COVID-19 positive patients cycle threshold demonstrated DNA DNA extraction DNA molecule evaluated faster genotyping healthy heterozygote heterozygous homozygote homozygous incidence Laboratory Leiden median Modification Mutation mutations outpatients patients with COVID-19 PCR performed positive positive patient protocol provided real time Real-time PCR reported SARS-CoV-2 virus significant difference significantly subject thawing thrombosis Venous Thromboembolism Whole blood whole blood sample [DOI] 10.33549/physiolres.934883 PMC 바로가기
Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity변이 유전 및 전사체 발현 분석은 코로나19 중증도에서 케모카인 수용체 CCR5의 역할을 보여주었다Article Published on 2021-09-012022-09-11 Journal: International immunopharmacology [Category] SARS, 변종, [키워드] 95%CI Analysis carrier CCR5 CCR5 delta32 Chemokine receptor controls COVID-19 COVID-19 severity Deletion expression genetic marker genetic susceptibility genotyped healthy control healthy controls homozygote ICU implicated IMPROVE intensive care intensive care unit less leukocyte leukocytes Ligand overexpressed Patient patients pharmacological SARS-CoV-2 significant difference significantly significantly higher transcript treatment for COVID-19 variant was measured [DOI] 10.1016/j.intimp.2021.107825 PMC 바로가기 [Article Type] Article
SELP Asp603Asn and severe thrombosis in COVID-19 malesSELP Asp603Asn 및 COVID-19 남성의 심각한 혈전증Letter to the Editor Published on 2021-08-162022-09-10 Journal: Journal of Hematology & Oncology [Category] MERS, SARS, 변종, [키워드] 95% CI Adhesion Molecule adjusted adjuvant therapy age androgen Androgen receptor Anti-selectin P monoclonal antibodies antibody Cell cell adhesion molecule coding variant Cohort confidence confidence interval COVID-19 D-dimer downregulated etiology Exome GEN-COVID homozygosity homozygote interval Logistic regression male Mortality Odds ratio Older P-selectin rationale receptor repurposing SARS-CoV-2 SELP Sequencing severity stratified by sex subject subjects supplementary material Testosterone the cell therapy Thromboembolism thrombosis thrombotic thrombotic risk Thrombus Venous Thromboembolism [DOI] 10.1186/s13045-021-01136-9 PMC 바로가기 [Article Type] Letter to the Editor
Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19Immunology Published on 2021-02-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] accompanied acute respiratory syndrome age allele Analysis application AUC Cell characteristic class Cohort connection contributed coronavirus Course COVID-19 Critical death deaths Deceased died Elderly patient Genotype genotypes high risk HLA HLA class I HLA-A HLA-B HLA-C homozygote human leukocyte antigen immune response independent manuscript MHC class I Next-generation sequencing Patient patients with COVID-19 peptide peptide presentation presenting resulting risk ROC Russia SARS-CoV-2 severity significantly higher Spanish patient T cells the disease two group viral infection viral peptide Volunteer [DOI] 10.3389/fimmu.2021.641900 PMC 바로가기 [Article Type] Immunology
The Prevalence of α-Thalassemia and Its Relation to Plasmodium falciparum Infection in Patients Presenting to Clinics in Two Distinct Ecological Zones in Ghanaarticle Published on 2016-12-312024-09-01 Journal: Hemoglobin [Category] 말라리아, [키워드] Coastal zone forest zone heterozygote homozygote Plasmodium falciparum thalassemia [Article Type] article
A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood MalariaA −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West [DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article