IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in SwedenResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] addition analysed baseline Biomarker Biomarkers C-reactive protein (CRP Care classical correlated correlation COVID-19 COVID-19 disease severity COVID-19 pandemic CRP Cytokine/IL-6 defined demonstrated Epidemiology First wave glycoprotein group groups hospital Hospital admission hospitalised patient IL-6 IL-6 pathway IL-6 receptor immune immune response Infection Inflammation intensive care involved Level longitudinal cohort study marker moderate moderate-severe Mortality not differ pathogen pathway Pathways Patient patients with moderate plasma Potential difference Respiratory Support Result severe COVID-19 severe SARS-CoV-2 sgp130 significantly sIL-6R with COVID-19 [DOI] 10.1016/j.cyto.2022.156020 [Article Type] Research article
Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patientsArticle Published on 2022-10-052022-11-16 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted Analysis Appendix approach assumption available data Calabria carrier caused changes in characterisation clinical Clinical outcome Clinical research clinical study collected Commonwealth confidence interval confounders COVID-19 dataset DAVID development Donor emergence Epidemiology European European Commission fatality Foreign foundation Frequency funding global health Google.org group heterogeneity Horizon hospital hospitalised hospitalised patient Imperial College London include infecting Infection Infectious disease International IRCCS ISARIC Italian Joshua less Logistic regression lower mortality Medical Research Council Medicine Melinda Gate Microbiology Ministry of Health network NIHR NIHR HPRU Odds ratio office omicron opportunity outcome Oxford Patient PHE protection Public Health England Rapid relative frequencies reported symptom Research respiratory response responsible Rockefeller Foundation SARS-CoV-2 variant School Semple sensitivity analysis Sriniva study population subset Support supported Symptoms union unit University of Liverpool University of Oxford variant variants viral genomic information viruses with COVID-19 [DOI] 10.7554/eLife.80556 PMC 바로가기
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] activated Admission Alpha Biomarkers Blood Cohort COVID-19 COVID-19 pandemic Critical care defined EGFR epidermal expression First wave Gene Expression gene expression signature gene signature growth factor healthcare Healthcare system hospital hospitalised hospitalised patient ICU admission individual information intensive care intensive care unit naïve outcomes pathway Patient patients with COVID-19 peroxisome predict predicted Predictive Prognosis prognostic receptor resource RNA RNA sequencing RNA-Seq RNA-seq - RNA sequencing ROC tested TGF-β topological data analysis Topology Transcriptome transforming growth factor Treatment was measured Whole blood with COVID-19 [DOI] 10.3389/fimmu.2022.988685 PMC 바로가기
Epidemiological model based periodic intervention policies for COVID-19 mitigation in the United KingdomArticle Published on 2022-09-192022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] adaptive addition alleviate Analysis average Community compartmental model country COVID-19 COVID-19 mitigation COVID-19 pandemic Deceased develop effective epidemiological facilitate fraction hospital hospitalisation hospitalised hospitalised patient identify Immunity Intervention limit maintain measure modulate National Health Service NHS parameter predict progression reduce Stage susceptible transmission rate United Kingdom vaccination variant [DOI] 10.1038/s41598-022-19630-6 PMC 바로가기
Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral ClearanceArticle Published on 2022-09-022022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] antibody B cell basophils CD4 T cells CD4+ CD4+ T cell CD4+ T cells cellular component correlated count COVID-19 Critical cytokine profile Delayed determinant disease deterioration help hospitalised patient Humoral response IL-9 immune activation immune parameter less longitudinal design magnitude MIF moderate Monocytes naïve naïve CD4+ T cell neutralising Neutralising Antibodies Neutrophils pro-inflammatory risk stratification SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease T cell Th2 the timing tissue damage viral clearance [DOI] 10.3390/cells11172743 PMC 바로가기
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Troponin and short-term mortality in hospitalised patients with COVID-19 infection: a retrospective study in an inner-city London hospitalObservational Study Published on 2022-08-242022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI age analysed association biochemical Cardiology collected COVID-19 death defined demonstrated East evaluate females hospital Hospital admission hospitalised hospitalised patient increased mortality independent Laboratory limit Local London Lung disease males men Mortality Patient patients with COVID-19 performed positive positive airway pressure Primary outcome public health regression analysis retrospective Retrospective study RT-PCR sensitivity significantly significantly higher specificity survival the patient troponin university with COVID-19 women [DOI] 10.1136/bmjopen-2022-061426 PMC 바로가기 [Article Type] Observational Study
Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort studyObservational Study Published on 2022-08-102022-10-04 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI addition average Canada Care clinically suspected Contact COVID-19 COVID-19 cases Department determine diagnose Diagnosis diagnostic Diagnostic microbiology eligible adult Emergency enrolled Epidemiology Factor Fever Health services healthcare worker hospital hospitalised hospitalised patient identify network nucleic acid amplification Observational cohort study Organisation of health services pandemic Patient patients positive Positive test Prevalence Rapid response resulting risk risk factor SARS-CoV-2 tested Universal [DOI] 10.1136/bmjopen-2021-057852 PMC 바로가기 [Article Type] Observational Study