Mortality among hospitalized COVID-19 patients during surges of SARS-CoV-2 alpha (B.1.1.7) and delta (B.1.617.2) variantsArticle Published on 2022-11-072022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] 95% CI Admission Alpha B.1.1.7 B.1.617.2 conducted contributed COVID-19 death Delta died evaluate Factor high mortality rate higher risk hospital hospitalizations hospitalized COVID-19 patient hospitalized patient hospitalized patients ICU Iran lack Nurse nutritional status occurred Patient patients with COVID-19 physician proportion risk of COVID-19 SARS-CoV-2 significantly significantly higher Tehran variant [DOI] 10.1038/s41598-022-23312-8 PMC 바로가기
‘Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM’ – Author’s replyArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] administration elevated hospitalized COVID-19 patient Inflammatory Tocilizumab [DOI] 10.1016/j.cmi.2022.06.028 PMC 바로가기
Re: Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORMArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] Abstract administration Anti-interleukin-6 receptor COVID-19 elevated hospitalized COVID-19 patient Inflammatory randomized clinical trial Sub-groupe analyses Tocilizumab tocilizumab. [DOI] 10.1016/j.cmi.2022.06.013 PMC 바로가기
Exploratory analysis of interleukin-38 in hospitalized COVID-19 patientsArticle Published on 2022-11-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] SARS, 바이오마커, [키워드] Adaptive immune response Admission age Analysis anti-inflammatory effect anti-inflammatory properties binding Biomarker cartilage CD244 CHL1 circulating Clinical data Cohort cohorts Concentration concentrations coronavirus disease correlated correlation COVID-19 COVID-19 patient COVID-19 severity disease dismutase dysregulated enzyme-linked immunosorbent exploratory fatty healthy control healthy controls healthy subjects hospital Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 Immunoglobulin in viral increase in infections Inflammatory biomarker intensive care interleukin-38 investigated men moderate Mortality no difference outcome plasma positive correlation positively correlated progression Protein proximity extension assay recent receptor reduce retrieved retrospective cohort study retrospective cohort study. SARS-CoV-2 SERPINA12 severity shown subjects thrombocyte TNF TNFRSF9 validation cohort were measured while women [DOI] 10.1002/iid3.712 PMC 바로가기
Serum hydroxybutyrate dehydrogenase and COVID-19 severity and mortality: a systematic review and meta-analysis with meta-regressionArticle Published on 2022-11-012022-11-15 Journal: Clinical and experimental medicine [Category] 바이오마커, [키워드] 95% CI Admission alteration Analysis Biomarker certainty of evidence Concentration conducted coronavirus disease COVID-19 COVID-19 patients COVID-19 severity disease severity effect size Egger estimates heterogeneity hospitalized COVID-19 patient hydroxybutyrate hydroxybutyrate dehydrogenase Inflammation Injury Liver damage magnitude marker Meta-analysis meta-regression moderate Mortality mortality. Myocardial myocardial injury non-specific non-survivor Patient performed renal renal function reported risk stratification searched Sepsis serum severity significantly significantly higher SMD standardized mean difference survival survivor systematic review tissue damage Web of Science [DOI] 10.1007/s10238-021-00777-x PMC 바로가기
Remdesivir modifies interferon response in hospitalized COVID-19 patientsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] 치료제, [키워드] hospitalized COVID-19 patient interferon response modify [DOI] 10.1016/j.jinf.2022.07.021 PMC 바로가기
Thromboprophylaxis with standard- vs. flexible-dose heparin for hospitalized COVID-19 patients: a target trial emulationResearch article Published on 2022-11-012022-10-05 Journal: Journal of clinical epidemiology [Category] 임상, [키워드] 28-day mortality 95% confidence interval Anticoagulants anticoagulation baseline bleeding Coagulopathy COVID-19 COVID-19 diagnosis COVID-19 drug treatment dose eligible Epidemiological methods estimate hazard ratio hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients intensity intermediate dose laboratory abnormality LMWH Low–molecular weight heparin Major Mortality objective Observational data Patient Result risk setting Spain Standard dose survival target Target trial emulation Thromboprophylaxis thrombosis thrombotic risk Trial [DOI] 10.1016/j.jclinepi.2022.08.006 [Article Type] Research article
DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasisArticle Published on 2022-10-262022-11-15 Journal: Mutagenesis [Category] 바이오마커, 치료제, [키워드] activated Analysis Antibiotics Anticoagulant antiviral therapy applied Bearing biochemical C-reactive protein (CRP Chest chest X-ray Concentration contribute control subjects Corticosteroid COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA DNA damage female Female patients Genetic Genome genotoxic healthy control healthy controls hematological parameters Hemostasis hemostasis abnormalities hospitalized COVID-19 patient IL-6 indicated Inflammation Inflammation. Inflammatory marker Laboratory laboratory parameter Laboratory parameters leukocyte lymphocyte neutrophil parameter performed peripheral blood lymphocyte Platelet positive positive correlation positively correlated procalcitonin reagent shown significantly significantly higher smoking statistically study population subjects therapy variety viral infections was measured X ray [DOI] 10.1093/mutage/geac011 PMC 바로가기
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patientsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody profiling blood sample cell death circulating neutrophil contributing to Control coronavirus COVID-19 degranulation disease disease severity driver dysregulated elevated experiment functions G-MDSC gene expression signature Granulocytic healthy donor hospitalized COVID-19 hospitalized COVID-19 patient Humoral response identify IgA IgA antibody IgG antibody Immunoglobulin induce longitudinal Mortality NETosis neutrophil Neutrophils Patient phagocytosis phenotype plasma plasma proteomics response RNA sequencing SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Severe patient severity Subtypes survived transcriptomics transcriptomics. [DOI] 10.1016/j.xcrm.2022.100779 PMC 바로가기
An explanatory model of depressive symptoms from anxiety, post-traumatic stress, somatic symptoms, and symptom perception: the potential role of inflammatory markers in hospitalized COVID-19 patientsArticle Published on 2022-10-102022-11-15 Journal: BMC Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis Anxiety anxiety symptom anxiety symptoms association back pain biological marker collected conducted COVID-19 COVID-19 pandemic cross-sectional demonstrated Depression depressive depressive symptom Depressive symptoms evaluate explain Factor highest hospital Hospitalized hospitalized COVID-19 patient hospitalized patient hypothese identify incidence individual Inflammation Inflammatory Inflammatory marker inflammatory markers Inflammatory response influence irritability marker mental health mental health problem NLR performed Peru post-traumatic Post-traumatic stress symptoms post-traumatic stress. predict Predictive Prevalence problem Psychological random Result Stress Symptom Symptoms variable vulnerable patient with COVID-19 [DOI] 10.1186/s12888-022-04277-4 PMC 바로가기