Antibody response and intra-host viral evolution after plasma therapy in COVID-19 patients pre-exposed or not to B-cell-depleting agentsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy Anti-spike anti-Spike IgG antibody antibody kinetics B-cell clinical care clinical status clinical symptom Complete contribute convalescent convalescent plasma COVID-19 patient Decline donors eligible evaluated Follow-up hospitalized COVID-19 patients humoral Humoral immunity IgG Immune escape Immunocompromised Immunocompromised patients Immunoglobulin impair lymphopenia majority management mRNA-based vaccine mRNA-based vaccine plasma mutation rate Patient patients treated plasma receiving SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2-specific antibodies severity spike mutations survival therapy titre viral control viral evolution virus clearance WHO whole-genome sequencing World Health Organization [DOI] 10.1111/bjh.18450 PMC 바로가기
Exploratory analysis of interleukin-38 in hospitalized COVID-19 patientsArticle Published on 2022-11-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] SARS, 바이오마커, [키워드] Adaptive immune response Admission age Analysis anti-inflammatory effect anti-inflammatory properties binding Biomarker cartilage CD244 CHL1 circulating Clinical data Cohort cohorts Concentration concentrations coronavirus disease correlated correlation COVID-19 COVID-19 patient COVID-19 severity disease dismutase dysregulated enzyme-linked immunosorbent exploratory fatty healthy control healthy controls healthy subjects hospital Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 Immunoglobulin in viral increase in infections Inflammatory biomarker intensive care interleukin-38 investigated men moderate Mortality no difference outcome plasma positive correlation positively correlated progression Protein proximity extension assay recent receptor reduce retrieved retrospective cohort study SARS-CoV-2 SERPINA12 severity shown subjects thrombocyte TNF TNFRSF9 validation cohort were measured while women [DOI] 10.1002/iid3.712 PMC 바로가기
Thromboprophylaxis with standard- vs. flexible-dose heparin for hospitalized COVID-19 patients: a target trial emulationResearch article Published on 2022-11-012022-10-05 Journal: Journal of clinical epidemiology [Category] 임상, [키워드] 28-day mortality 95% confidence interval Anticoagulants anticoagulation baseline bleeding Coagulopathy COVID-19 COVID-19 diagnosis COVID-19 drug treatment dose eligible Epidemiological methods estimate hazard ratio hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients intensity intermediate dose laboratory abnormality LMWH Low–molecular weight heparin Major Mortality objective Observational data Patient Result risk setting Spain Standard dose survival target Target trial emulation Thromboprophylaxis thrombosis thrombotic risk Trial [DOI] 10.1016/j.jclinepi.2022.08.006 [Article Type] Research article
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication
Association of human myxovirus resistance protein A with severity of COVID-19Article Published on 2022-09-282022-11-15 Journal: BMC Infectious Diseases [Category] 바이오마커, [키워드] 95%CI Admission applied baseline characteristics Biomarker Blood clinical parameter correlation Corticosteroid COVID-19 disease duration of hospitalization duration of symptom group hospital Hospitalization hospitalized COVID-19 patients Human Human myxovirus resistance protein A inflammatory biomarker level initial MxA Odds ratio Patient Peripheral blood predict Protein protein A Respiratory Support retrospective cohort study SARS-CoV-2 severe COVID-19 severe disease severity severity of COVID-19 Severity of disease significantly higher the disease was determined was measured [DOI] 10.1186/s12879-022-07753-0 PMC 바로가기
Usefulness of KL-6 for Predicting Clinical Outcomes in Hospitalized COVID-19 PatientsArticle Published on 2022-09-212022-11-15 Journal: Medicina [Category] 바이오마커, [키워드] 30-Day mortality 95% confidence interval acute lung injury Admission age Analysis analyzed automated Biomarker CCI characteristic clinical Clinical outcome clinical outcomes Comorbidity contribute coronavirus disease COVID-19 COVID-19 patient Critical care Critical disease demonstrated ECMO extracorporeal membrane oxygenation hazard ratio Hospitalized hospitalized COVID-19 patients ICU admission initial intensive care Interstitial lung disease Japan Kaplan-Meier method Kaplan-Meier survival analysis KL-6 Kobe outcome patients predict predicted prediction quartile reflect Result ROC ROC Curve significantly ventilator were measured [DOI] 10.3390/medicina58101317 PMC 바로가기
The predictive value of epicardial fat volume for clinical severity of COVID-19Research article Published on 2022-09-012022-10-05 Journal: Revista portuguesa de cardiologia [Category] 바이오마커, [키워드] adipose Admission age Analysis analyzed association C-reactive protein characteristic Clinical severity Computed tomography coronavirus disease COVID-19 CRP death disease severity Epicardial fat volume fat ferritin ferritin level hospitalized COVID-19 patients ICU ICU Patients IL-6 IL-6 level independent Inflammatory biomarker Inflammatory cytokine intensive care interleukin-6 male morbidity and mortality multivariate logistic regression objective occurred outcome Patient patients died patients with COVID-19 PCT positive correlation predict predicted Predictive primary composite endpoint procalcitonin Prognosis Result Retrospective study serum CRP severe complications significant level significantly higher tissue tomography Volume was determined were infected were measured with COVID-19 [DOI] 10.1016/j.repc.2021.05.016 [Article Type] Research article
Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimenArticle Published on 2022-09-012022-11-16 Journal: BMB reports [Category] 유전자 메커니즘, [키워드] approval B cell BCR Biobank biospecimen clinical collected contribute coronavirus disease COVID-19 COVID-19 infection COVID-19 patient cytokine dataset Diagnosis Disease progression distribution facilitate healthy controls help HLA hospitalized COVID-19 patients immune profiling immune response Infection initial involved laboratory characteristics mechanism methodology molecular mechanism outbreak pandemic Pandemics performed receptor report researcher Sequencing Single-cell RNA sequencing T cell receptor TCR TCR sequencing Treatment understanding Viral genome sequencing WGS whole genome [DOI] 10.5483/BMBRep.2022.55.9.077 PMC 바로가기
The effects of high dose vitamin D supplementation as a nutritional intervention strategy on biochemical and inflammatory factors in adults with COVID-19: Study protocol for a randomized controlled trialCOVID-19 성인의 생화학적 및 염증 인자에 대한 영양 중재 전략으로서 고용량 비타민 D 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-09-012022-09-11 Journal: Nutrition and health [Category] 바이오마커, 임상, [키워드] All participant All participants Analysis baseline biochemical blood count both groups CBC changes in chest CT scan classification clinical outcomes complete blood count conducted confounders control group covariance COVID-19 Descriptive statistics diagnosis of COVID-19 double-blind duration of hospitalization Effect erythrocyte sedimentation erythrocyte sedimentation rate ESR Evidence followed by gel heart High dose hospitalized COVID-19 patients hs-CRP Imam in both groups Inflammation Inflammatory factor Inflammatory marker inflammatory markers intervention group Iran Laboratory life liver Mashhad mortality rate New York nutritional intervention parameter participant Patient performed Placebo protocol Quality of life randomization Randomized Randomized controlled trial receive recorded renal Reza risk factor RT-PCR sedimentation rate serum serum vitamin D shown study period Trial undergo Vitamin D Vitamin D supplementation with COVID-19 [DOI] 10.1177/02601060221082384 PMC 바로가기 [Article Type] Article
Circulating Ubiquitous RNA, A Highly Predictive and Prognostic Biomarker in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients순환 유비쿼터스 RNA, 입원한 코로나바이러스 질환 2019(COVID-19) 환자의 고도로 예측하고 예후가 좋은 바이오마커Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Biomarker Biomarkers Blood cell lysis Chain Reaction circulating Clinical management clinical monitoring clinical outcomes Clinical severity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients Critical ddPCR death develop disease severity Diseases evaluate Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infectious diseases Invasive mechanical ventilation lung cell management marker multi-organ failure organ injury overall survival Patient plasma polymerase chain polymerase chain reaction predict Predictive predictive and prognostic biomarkers prognostic Prognostic biomarkers quantification respiratory respiratory distress Respiratory distress syndrome RNA RNase P RNAseP SARS-CoV-2 SARS-CoV-2 and RNAseP RNAemia severe acute respiratory syndrome Coronavirus severe and critical patients severity significantly survival syndrome tissue injury tissue/cell lysis biomarker. Viral [DOI] 10.1093/cid/ciab997 PMC 바로가기 [Article Type] Article