Gut microbiota composition is associated with disease severity and host immune responses in COVID-19article Published on 2023-12-122024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] COVID-19 disease severity gut microbiota host immune responses Opportunistic Pathogens [DOI] 10.3389/fcimb.2023.1274690 PMC 바로가기 [Article Type] article
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitopeArticle Published on 2022-10-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody binding Antibody Response association competing cryo-EM Delta delta variant disrupt elicit epitope evade host immune responses hydrophobic immune evasion immune response impair inhibiting Interaction L452R Lineage mechanism Mutation neutralization omicron Population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike receptor-binding domain spike variants Spread Substitution substitutions target thought variant virus entry virus variants [DOI] 10.1038/s41564-022-01235-4 PMC 바로가기
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?Review article Published on 2022-10-012022-10-05 Journal: Environmental toxicology and pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Can Concentration Control copper correlated COVID-19 COVID-19 patients death rate deficiency dispersal exhibit facilitate host immune responses increase in independent risk factor Infection Inflammatory cytokine iron modify outcome oxidative stress Patient Prognosis prognostic regulate replication of SARS-CoV-2 risk of infections SARS-CoV-2 Selenium serum serum Cu levels severe COVID-19 significantly higher Spike protein suppress the SARS-CoV-2 viral genome viral replication while worse prognosis Zinc [DOI] 10.1016/j.etap.2022.103937 [Article Type] Review article
A Game of Infection – Song of Respiratory Viruses and Interferons감염의 게임 - 호흡기 바이러스와 인터페론의 노래Review Published on 2022-06-292022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 coronavirus disease acute respiratory syndrome Antiviral Antiviral strategies antiviral strategy cause caused coronavirus coronavirus – COVID-19 coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic CoVs death deaths disease pathogenesis driving effective flu game Health Host Host immune response host immune responses immune responses Infection Influenza influenza A influenza A virus Influenza virus influenza viruses innate immune innate immune response innate immune responses innate immune system Innate immunity mechanism outcome pandemic Pandemics pathogen Pathogenesis Pathogens recorded Research respiratory SARS-CoV-2 Severe acute respiratory syndrome singular Song Spanish flu swine flu therapeutic Topic translated virus virus infection Virus-host interaction Virus-host interactions while writing [DOI] 10.3389/fcimb.2022.937460 PMC 바로가기 [Article Type] Review
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes중증 급성 호흡기 증후군 코로나바이러스 2 바이러스혈증은 코로나바이러스 질병 2019 심각도와 연관되어 있으며 임상 결과를 예측합니다Observational Study Published on 2022-05-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 19 outcome 2 RNAemia 2 viremia acute respiratory syndrome acute respiratory syndrome coronavirus Admission Antibody titers bloodstream Care clinical clinical outcomes Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patient COVID-19 severity cross-sectional discharge disease severity electron tomography hazard ratio Health Organization Hospitalized Host immune response host immune responses ICU ICU Patients immune responses immunostaining indicate Inflammatory biomarker Inpatients Level Mortality Neutralizing antibody titer neutralizing antibody titers non-ICU outcome outcomes Outpatient outpatients Patient pellet plasma plasma sample plasma samples quantified reflect respiratory SARS SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Viral Viral RNA Viremia virion virions virus particle virus particles Visualization vRNA WHO World Health Organization [DOI] 10.1093/cid/ciab686 PMC 바로가기 [Article Type] Observational Study
Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccinationReview Published on 2022-05-012023-07-07 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] furin cleavage site host immune responses Pathogenesis SARS-CoV-2 Spike protein vaccination [DOI] 10.1002/jmv.27539 [Article Type] Review
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)AZD1222(ChAdOx1 nCoV-19) 백신을 접종한 쥐의 시험관 내 SARS-CoV-2 스파이크 단백질 발현 및 혈액학적 효과Article Published on 2022-04-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adenovirus Adenovirus-vectored vaccine AZD1222 AZD1222 (ChAdOx1 nCoV-19) blood cell cells ChAdOx1 ChAdOx1 nCoV-19 change cleavage cleaved COVID-19 COVID-19 vaccination COVID-19 vaccine detectable Disease progression Effect Evidence expected expression hematologic hematology parameter Hematology parameters host cell host cells Host immune response host immune responses immediate effect immediate effects immune responses immunization immunohistochemistry in vitro in vivo Infection innate immune response intramuscular intravenous investigated mice morbidity morbidity and mortality nCoV neutrophil occurred parameters plasma concentration Platelet platelet activation platelet and white blood cell parameters. produced promote Protein prothrombotic state Respiratory failure response risk S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera severe COVID-19 spike spike glycoprotein Spike protein the S1 subunit undetectable vaccination vectored vaccine vehicle Viral Viral particles White blood cell [DOI] 10.3389/fimmu.2022.836492 PMC 바로가기 [Article Type] Article
Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern베타, 델타 및 기타 우려되는 SARS-CoV-2 변이체에 대한 BBIBP-CorV 백신 유도 혈청의 중화 활성Clinical Trial Published on 2022-04-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha antibody BBIBP-CorV Beta boost clinical trial Cohort coronavirus Delta Gamma global pandemic Host immune response host immune responses immune responses immunogenicity inactivated indicate Iota neutralization neutralization potency Neutralizing recipient recipients reduction in Registered respiratory SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus term Vaccinations Vaccine vaccine dose variant variants [DOI] 10.1038/s41467-022-29477-0 PMC 바로가기 [Article Type] Clinical Trial