Spatiotemporal pattern recognition and dynamical analysis of COVID-19 in Shanghai, ChinaArticle Published on 2022-12-072022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Autocorrelation analysis China COVID-19 COVID-19 disease Daily Daily reproduction number diffusion disease dissemination dynamic Dynamic model early stage Effect hotspot IMPROVE mutant omicron outbreak provided retrospective SARS-CoV-2 transmission Shanghai Spatial statistics. spatiotemporal statistical suffered suppress the epidemic [DOI] 10.1016/j.jtbi.2022.111279 PMC 바로가기
Building-level wastewater surveillance of SARS-CoV-2 is associated with transmission and variant trends in a university settingArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant analyzed associations Building-level surveillance Clinical data clinical testing collected complement Concentration contributed COVID-19 COVID-19 case creating Epidemiology genetic mutation hotspot identify include indicate Intervention Isolation less log N1 and N2 Nucleocapsid gene positive positive control quantification quarantine repeated reported Research SARS-CoV-2 SARS-CoV-2 RNA second wave South spring statistical significance statistically significant Surveillance Transmission university variant variants of concern Viral RNA Viral transmission VOCs Wastewater-based epidemiology [DOI] 10.1016/j.envres.2022.114277 PMC 바로가기
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Decoding the effects of spike receptor binding domain mutations on antibody escape abilities of omicron variantsArticle Published on 2022-10-302022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities antibodies antibody Antibody binding antibody escape appear approach approved binding affinity binding free energy cause Coverage COVID19 decrease Effect evaluate globe hotspot immune evasion immunogenic Immunogenic hotspot immunoinformatics K417N monoclonal antibody mutant Mutation mutations omicron Omicron variant Omicron variants Omicron variants. Point mutation RBD mutation RBD-specific antibody recent Receptor binding domain reduce reduction in REGN10987 residue selection pressure significantly single mutation the binding affinity therapeutic vaccination variants [DOI] 10.1016/j.bbrc.2022.08.050 PMC 바로가기
De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsArticle Published on 2022-10-282022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Antiviral binding coronavirus Critical de novo evade exhibited hACE2 host cell hotspot human Angiotensin-converting enzyme immune in vitro Interaction Ligand Neutralizing nucleic acids Occurrence omicron peptide Prophylaxis random reagents Receptor binding receptors recruit SARS-CoV-2 SARS-CoV-2 variant selected Tolerance Vaccine variant variants viral variant virus [DOI] 10.1126/sciadv.abq6207 PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
SARS-CoV-2 Spatiotemporal Genomic and Molecular Analysis of the First Wave of the COVID-19 Pandemic in Macaé, the Brazilian Capital of OilArticle Published on 2022-09-292022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] Analysis B.1.1.28 B.1.1.33 Brazil Capital Clinical data COVID-19 COVID-19 pandemic COVID-19 severity death Epidemiology event functional genomic hotspot human ACE2 Integrative analysis Interaction Lineage Local Macaé molecular molecular interaction mutated Occurrence Oil outbreak Patient performed SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 virus infection second Spike protein Spread target the SARS-CoV-2 Transmission viral lineages viral mutation virus Wave wild-type [DOI] 10.3390/ijms231911497 PMC 바로가기
Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosisArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] acute injury Analysis analyzed article changed Cluster collected Comorbidities coronavirus 2 coronavirus disease country COVID-19 COVID-19 pandemic Cystic database Diagnosis early phase English enrolled Epidemiology etiology Evidence experiment fibrosis French hotspot hotspots and trends Imperial College London Increasing individual level Infection international cooperation intrinsic investigated journal Laboratory Lung function material novel Pathogenesis Patient professional promote public health threat Quality of life Research reversed Spread Therapies therapy university University of Washington USA vaccination Volume was performed Web of Science [DOI] 10.3389/fpubh.2022.967829 PMC 바로가기
Long-term monitoring of SARS-CoV-2 RNA in sewage samples from specific public places and STPs to track COVID-19 spread and identify potential hotspotsCOVID-19 확산을 추적하고 잠재적인 핫스팟을 식별하기 위해 특정 공공 장소 및 STP의 하수 샘플에서 SARS-CoV-2 RNA의 장기 모니터링Article Published on 2022-09-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] air airport analyzed Asymptomatic Brazil can be used caused Concentration COVID-19 COVID-19 cases death detect dissemination epidemiological epidemiological situation epidemiological surveillance Epidemiology FIVE greater highest hotspot identify indication Infection International airport Local local outbreaks much lower non-infected Outbreaks pandemic plant Public Public places RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA selected sentinel Sentinel sewage surveillance sewage Sewage treatment Sewage treatment plant SHC1 SHC2 Spread suggested Surveillance symptomatic Treatment Viral concentration viral concentrations Waterwater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.155959 PMC 바로가기 [Article Type] Article
Impact of ventilation and avoidance measures on SARS-CoV-2 risk of infection in public indoor environments공공 실내 환경에서 SARS-CoV-2 감염 위험에 대한 환기 및 회피 조치의 영향Article Published on 2022-09-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] approach avoidance B.1.1.529 Computational fluid dynamics Computational Fluid Dynamics (CFD) conducted Contact COVID-19 delta variant Dynamics Efficacy Engagement estimate Face mask feasible Frequency hand hygiene hotspot hygiene Impact include induce Infection infection risk infections Masks measure Measures mitigate omicron position Probability promoted Protective Protective behaviours protective factor public health reducing required Research resulting risk risk of infection sanitising SARS-CoV-2 SARS-CoV-2 virus secondary infections Simulation Spread the SARS-CoV-2 virus Transmission vaccination variant Ventilation was measured wearing masks windows [DOI] 10.1016/j.scitotenv.2022.156518 PMC 바로가기 [Article Type] Article