Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disordersarticle Published on 2024-01-042024-09-05 Journal: Current neuropharmacology [Category] update2024, [키워드] basolateral amygdala Brain morphology HPA PTSD stress response systems [DOI] 10.2174/1570159X21666230703091435 PMC 바로가기 [Article Type] article
Harnessing Natural Products by a Pharmacophore-Oriented Semisynthesis Approach for the Discovery of Potential Anti-SARS-CoV-2 Agents잠재적인 Anti-SARS-CoV-2 제제의 발견을 위한 약동학 지향 반합성 접근법에 의한 천연물 활용Article Published on 2022-07-112022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 치료제, [키워드] agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Agents antiviral activity applied approach assembly cascade Cell complex structure creation Domino Reactions EpiC HPA inhibited mechanism natural natural products oridonin pharmacophore Potential product Rearrangement Remdesivir SARS-CoV-2 replication Semisynthesis suggested unique Wolff Wolff Rearrangement. [DOI] 10.1002/anie.202201684 PMC 바로가기 [Article Type] Article
Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19Review article Published on 2022-07-012022-10-05 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis [DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article
Opioid-blunted cortisol response to stress is associated with increased negative mood and wanting of social reward Research Published on 2022-02-092022-10-05 Journal: Neuropsychopharmacology [Category] 바이오마커, [키워드] Acute stress administration Affect animal double-blind elicited Evidence female healthy HPA Human morphine participant Placebo prevented Psychosocial stress Randomized reaction receptor Regulation Research salivary seeking social contact Stress Volunteer were assessed [DOI] 10.1038/s41386-022-01283-8 [Article Type] Research
Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltrationResearch Paper Published on 2022-01-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] acute respiratory syndrome Algorithms Analysis cellular CIBERSORT clinicopathological parameter coronavirus correlated COVID-19 Cox regression Decreased DNA methylation drug target examined exhibited expression GEO global pandemic GSEA HPA immune Immune cell infiltration immune infiltration investigated KEGG lung cancer lung cancer patient lung cancer patients metabolic pathway molecular function mRNA mRNA expression outcome pathway Patient performed poor prognosis predict predictive power prognostic prognostic biomarker Prognostic value protease protein expression reduced SARS-CoV-2 SARS-CoV-infected cells serine 2 significantly Spread survival therapeutic target TMPRSS2 TMPRSS2 expression transmembrane was determined [DOI] 10.18632/aging.203823 PMC 바로가기 [Article Type] Research Paper
Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 QuarantineReview Published on 2021-12-082022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Anxiety association COVID-19 COVID-19 pandemic Evidence Generalized Health heterogenous HPA Impact implication Implications locus loneliness mechanism morbidity Mortality nucleus quarantine social isolation Solutions [DOI] 10.3390/brainsci11121620 PMC 바로가기 [Article Type] Review
COVID-19 and chronic fatigue syndrome: An endocrine perspectiveSpecial Issue: COVID19 and Endocrinology Published on 2021-12-032022-10-04 Journal: Journal of Clinical & Translational Endocrinology [Category] 진단, [키워드] adrenal function assessment Cardiopulmonary Chronic fatigue chronic fatigue syndrome Complication COVID-19 COVID-19 symptom diagnostic Endocrine Endocrinopathy help HPA identify individual involved Long COVID management Pain pathophysiological mechanism Perspective Pituitary problem Psychological recovering from COVID-19 rehabilitation Support Symptom Thyroid thyroid function [DOI] 10.1016/j.jcte.2021.100284 PMC 바로가기 [Article Type] Special Issue: COVID19 and Endocrinology
Expression profile of SARS‐CoV‐2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma정상 구강 점막 및 구강 편평 세포 암종에서 SARS-CoV-2 세포 진입 단백질의 발현 프로파일Short Communication Published on 2021-11-022022-09-11 Journal: Clinical and Experimental Dental Research [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Atla body tissues Cell cellular entry COVID‐19 dataset datasets enzyme Evidence examined except for expression expression level expression levels expression profile expression profiles expression profiling furin head cancer HPA Human independent lesion Microarray moderate mRNA neck cancer objective oral cancer oral mucosa organ organs profile protease Proteases Protein protein expression Proteins proteomics Public relative susceptibility Result risk Risk assessment SARS‐CoV‐2 SARS‐CoV‐2 infection Squamous cell Squamous cell carcinoma tissue tissues TMPRSS2 tongue transcriptomic were used [DOI] 10.1002/cre2.510 PMC 바로가기 [Article Type] Short Communication
Pituitary–Adrenal Responses and Glucocorticoid Receptor Expression in Critically Ill Patients with COVID-19Review Published on 2021-10-252022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] clinical study Consequences coronavirus disease COVID-19 Critical Critical illness Critically ill patient Defense described expression GCR glucocorticoid HPA Ill Inflammation inflammatory reaction magnitude metabolic effects receptor response Stress systemic inflammation tissue tissue damage with COVID-19 [DOI] 10.3390/ijms222111473 PMC 바로가기 [Article Type] Review
What we have to know about corticosteroids use during Sars-Cov-2 infectionSars-Cov-2 감염 중 코르티코스테로이드 사용에 대해 알아야 할 사항Review Published on 2021-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] SARS, 치료제, [키워드] acute respiratory syndrome addition Adrenal Adrenal insufficiency affected antiretroviral drug antiretroviral drugs antiviral therapy available data caused co-morbidities concomitant treatments consequence Corticosteroid Corticosteroids cortisol COVID-19 COVID-19 outbreak Critical Critical illness dose drug drug interaction Drug interference drug withdrawal drug-drug interaction drugs ENhance exposure to gcs Glucocorticoid treatment Glucocorticoids HPA hypercortisolism hypoadrenalism impairment Infection Interaction involved literature management morbidities morbidity and mortality mortality risk pathway Patient physician risk SARS-CoV SARS-CoV 2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients secretion Severe acute respiratory syndrome Steroids Symptom therapy treat Treatment Withdrawal [DOI] 10.1007/s40618-020-01384-5 PMC 바로가기 [Article Type] Review