Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2Research Published on 2024-01-252024-09-05 Journal: Virology Journal [Category] update2024, [키워드] HEK293 cells human ACE2 quercetin SARS-CoV-2 Spike protein syncytium formation [DOI] 10.1186/s12985-024-02299-w PMC 바로가기 [Article Type] Research
SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse modelArticle Published on 2023-03-202024-09-05 Journal: Antiviral Research [Category] update2024, [키워드] Brain COVID-19 human ACE2 Human CD34 immune cells mouse model NCG neurotropism omicron SARS-CoV-2 T cell [DOI] 10.1016/j.antiviral.2023.105580 PMC 바로가기 [Article Type] Article
Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)인간 ACE2와 베타코로나바이러스(SARS-CoV-1 및 SARS-CoV-2)의 스파이크 RBD 간의 상호작용에 대한 열역학적 분석Article Published on 2023-01-012023-07-10 Journal: FEBS Open Bio [Category] COVID19(2023년), [키워드] binding interactions human ACE2 isothermal titration alorimetry Receptor-binding domain SARS-CoV-1 SARS-CoV-2 [DOI] 10.1002/2211-5463.13525 PMC 바로가기
The Development of Pharmacophore Models for the Search of New Natural Inhibitors of SARS-CoV-2 Spike RBD-ACE2 Binding InterfaceArticle Published on 2022-12-152023-07-11 Journal: Molecules [Category] COVID19(2023년), [키워드] human ACE2 Induced fit docking natural compound pharmacophore model SARS-CoV-2 inhibitors spike RBD [DOI] 10.3390/molecules27248938 PMC 바로가기
Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant variant of concern Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variantArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme coronavirus COVID-19 domain Effect ENhance human ACE2 human Angiotensin-converting enzyme humans infect investigated mouse angiotensin-converting enzyme 2 Mutation Mutational hotspots N501Y Omicron variant question raised RBD receptor Receptor-binding domain (RBD) SARS-CoV-2 Spread the RBD viral adaptation X-ray X-ray crystallography [DOI] 10.1073/pnas.2206509119 PMC 바로가기
In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 bindingSARS-CoV-2 스파이크 단백질 N501Y 및 N501T 돌연변이가 인간 ACE2 결합에 미치는 영향에 대한 실리코 분석Article Published on 2022-11-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed anti-SARS-CoV-2 antibodies Anti-viral drugs antisense attachment binding binding energy binding free energy classic Dynamics Effect Effect of mutations on binding energy effective free energy hACE2 hACE2 receptor hACE2-SARS-CoV-2 spike protein binding. handling highlight Host human ACE2 maintain molecular molecular dynamics molecular dynamics simulations Mutation N501Y N501Y and N501T mutations nine outcome predicted Protein binding raised Replication SARS CoV SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike protein Spike protein survival Transmissibility treatment strategy Vaccines virus [DOI] 10.1016/j.jmgm.2022.108260 PMC 바로가기 [Article Type] Article
Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5Article Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 binding alveolar epithelial cell BA.2 BA.2.12.1 BA.4 BA.5 bind Characteristics COVID-19 Culture effective experiment greater hamster Health human ACE2 immune immune evasion immune resistance Immunity Infection less omicron pathogenic pathogenicity provided replicate Reproduction number risk SARS-CoV-2 spike receptor-binding domain Spread statistical analysis Substitution suggested the SARS-CoV-2 Transmissibility [DOI] 10.1016/j.cell.2022.09.018 PMC 바로가기
Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacyArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 angiotensin-converting enzyme 2 Biomarker change changes in circulating cleaved COVID-19 death declined demonstrated Disease progression dose Efficacy elevated expressing full-length highlight host cell receptor human ACE2 humans immunization increase in K18-hACE2 mice membrane mice MVA-S vaccine prevented Proteolytic processing receptor SARS-CoV-2 SARS-COV-2 infection serum serum sample subsequent susceptible the SARS-CoV-2 transgenic vaccination Vaccine vaccine candidate virus virus entry [DOI] 10.3389/fimmu.2022.1001951 PMC 바로가기