Atomistic insights into the binding of SARS-CoV-2 spike receptor binding domain with the human ACE2 receptor: The importance of residue 493Article Published on 2023-01-012023-07-10 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), [키워드] COVID-19 human ACE2 receptor MM-GBSA molecular dynamics omicron Receptor binding domain Residue mutations SARS-CoV-2 Spike protein [DOI] 10.1016/j.jmgm.2022.108360 PMC 바로가기
Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptorsSARS-CoV-2 스파이크 돌연변이는 바이러스 스파이크와 인간 ACE2 수용체 간의 상호 작용을 수정합니다Article Published on 2022-09-102022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding carried complex COVID-19 Effectiveness ENhance feature Health highest human ACE2 receptor Infection interact Interaction interface interface region Interface residues investigated modify molecular molecular interaction mutability Mutation mutations neutralization observé professional Protein question Repurposed drug Repurposed drugs researchers residue SARS-CoV-2 SARS-CoV-2 Spike mutation SARS-CoV-2 virus Scientific community severity significantly spike Spike protein spike-ACE2 stability the SARS-CoV-2 virus the Spike Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2022.06.064 PMC 바로가기 [Article Type] Article
Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface ComplexArticle Published on 2022-09-032022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] AABPU ACE2 Affect Amino acid atomic level bind Delta delta variant distributions domain Effect Efficacy help human ACE2 receptor Impact implication in-depth analysis information Interaction interactions interatomic interaction interface mechanism Mutation omicron Omicron variant partial charge. penetration RBD RBD mutation RBD-ACE2 RBD-ACE2 complex RBD-SD1 domain S-protein SARS-CoV-2 SARS-CoV-2 virus significantly increased specific mutation spike-protein the Spike Therapies Treatment Vaccine variant wild-type strain [DOI] 10.3390/ijms231710091 PMC 바로가기
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Butein as a potential binder of human ACE2 receptor for interfering with SARS-CoV-2 entry: a computer-aided analysisSARS-CoV-2 진입을 방해하기 위한 인간 ACE2 수용체의 잠재적 결합제로서의 부테인: 컴퓨터 지원 분석Article Published on 2022-08-242022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin antiviral activity atomic level Butein clinical trials Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dietary supplement drug candidate effective examined hACE-2 hACE2 hACE2 receptor herbal compound herbal compounds host cell host cells human ACE2 receptor human Angiotensin-converting enzyme In silico methods Infection infections Interaction interfere molecular molecular docking molecular dynamics Molecular modeling natural natural products pathogen Pathogens physicochemical Phytoconstituents profile receptor Recognition researcher SARS-CoV-2 screened selected severe acute respiratory syndrome Coronavirus shown Spike protein subset target protein therapeutic these compound these compounds viral entry viral particle Viral particles zoonotic [DOI] 10.1007/s00894-022-05270-0 PMC 바로가기 [Article Type] Article
Honghua extract mediated potent inhibition of COVID-19 host cell pathways홍화 추출물 매개 코로나19 숙주 세포 경로의 강력한 억제Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제, [키워드] alkaline phosphatase Analysis Antiviral effect applied Chinese Compound COVID-19 crocin enzyme exhibited Extract high affinity host cell human ACE2 receptor Inflammation investigated kinases mechanism Medicine network pharmacology pathway Pathway analysis phosphatase potential mechanism potential mechanisms Signaling signaling pathway Simulation Traditional Traditional Chinese medicine virus [DOI] 10.1038/s41598-022-15338-9 PMC 바로가기 [Article Type] Article
Cross-Neutralization of SARS-CoV-2-Specific Antibodies in Convalescent and Immunized Human Sera against the Bat and Pangolin Coronaviruses박쥐 및 천산갑 코로나바이러스에 대한 회복기 및 면역화된 인간 혈청에서 SARS-CoV-2-특이적 항체의 교차 중화Article Published on 2022-08-162022-09-12 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 analyzed appear bat bat coronavirus binding Cell cell-cell fusion chimeric chimeric proteins contribute coronavirus COVID-19 COVID-19 patient cross-neutralize highest Human human ACE2 receptor human host immunized inactivated induce less neutralization neutralization activity neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody overexpressing pandemic pangolin pangolin coronavirus pangolins pre-existing immunity promote Protein pseudo-virus pseudo-virus. RaTG13 RBD replaced sarbecovirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine serum sample significantly significantly higher spike the RBD the receptor-binding domain thought transmitted vaccination VeroE6 cells while widespread [DOI] 10.3390/v14081793 PMC 바로가기 [Article Type] Article
Structural Evolution of Delta (B.1.617.2) and Omicron (BA.1) Spike Glycoproteins델타(B.1.617.2) 및 오미크론(BA.1) 스파이크 당단백질의 구조적 진화Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] accumulated alteration B.1.617.2 binding caused conservation coronavirus COVID-19 COVID-19 pandemic Delta elements Evolution fusion genomic data glycan glycans glycoprotein host cell human ACE2 receptor involved membrane fusion molecular molecular dynamics monomer mutants Mutation offer omicron proximal RBD receptor ACE2 Receptor binding domain receptor binding motif Region S glycoprotein SARS-CoV-2 spike structural evidence Transmissibility unique variants virus entry [DOI] 10.3390/ijms23158680 PMC 바로가기 [Article Type] Article