human epithelial cells – Communicable Diseases Research

Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection

article

Published on 2023-04-192024-09-05
Journal: mBio [Category] update2024,

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

칸나비노이드는 SARS-CoV-2 및 새로운 변이체의 세포 진입을 차단합니다

Article

Published on 2022-01-282022-09-11
Journal: Journal of natural products [Category] Coronavirus, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affinity Alpha Alpha variant B.1.1.7 B.1.351 Beta variant block cannabinoid cannabinoids cannabis cells complement Coronavirus-2 COVID-19 effective epithelial cells expressing Follow-up hemp human epithelial cell human epithelial cells Infection Ligand live SARS-CoV-2 mass spectrometry Prevent prevented pseudovirus Safe SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein the SARS-CoV-2 the spike protein therapeutic agent treat Vaccines variant variants virus neutralization assays was used
[DOI] 10.1021/acs.jnatprod.1c00946 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

SARS-CoV-2 감염은 cGAS-STING 및 NF-κB를 통해 전염증성 사이토카인 반응을 유도합니다

Article

Published on 2022-01-122022-09-10
Journal: Communications Biology [Category] 치료기술, 치료제,

[키워드] Activation antiviral responses block building Cell cGAS complications contribute cytokine cytokine secretion profile Cytokines death detect develop drugs epithelial cells evaluate evaluated global pandemic human epithelial cell human epithelial cells individual induce infected cell culture infected patients infections Inflammatory cytokine Inflammatory cytokines inflammatory immune response Inflammatory response Inflammatory responses IRF3 lead leads long-lasting lung damage majority Mild Mild disease NF-κB nuclear translocation Patient patient sera pro-inflammatory cytokine pro-inflammatory cytokines proportion SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection Severe case severe disease severe symptom severe symptoms Spread STING suppress Symptoms therapy transcriptional upregulation viral pathogenesis virus
[DOI] 10.1038/s42003-021-02983-5 PMC 바로가기 [Article Type] Article

Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Letter to the Editor

Published on 2021-09-072022-10-31
Journal: Military Medical Research [Category] COVID-19, Fulltext, SARS,

Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic Agents

Brief Report

Published on 2021-08-232022-10-28
Journal: Plants [Category] COVID-19,

Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor

Communication

Published on 2021-08-102022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] absence ACE2 acute respiratory syndrome Analysis bind binding blocking Candidates caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics demonstrated effective Effectiveness Elaeocarpus sylvestris entry of SARS-CoV-2 enzyme-linked immunosorbent geraniin hACE2 hACE2 receptor high affinity Human human Angiotensin-converting enzyme human cells human epithelial cells indicated ingredient inhibit Interaction investigated natural pandemic plant Protein Proteins RBD receptor residue SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome coronavirus 2 spike Spike protein the SARS-CoV-2 the spike protein therapeutic treating COVID-19 Vaccines VAR viral entry virus entry
[DOI] 10.3390/ijms22168604 PMC 바로가기 [Article Type] Communication

Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns

Research Article

Published on 2021-04-132022-10-29
Journal: mBio [Category] Coronavirus, SARS,

[키워드] activities activity Antiviral antiviral action antiviral activity antiviral response Cell cell lysis cells class damage-associated molecular pattern damaged cells DAMP DAMPs dead Defense detect disrupt engage event Host human epithelial cells include induce Infection Inflammatory Influenza virus Innate immunity interferon response limit Lipid lipids lung mechanism microbial oxidized oxPAPC oxygenated PAMP PAMPs pathogen-associated molecular pattern pattern Phosphatidylcholine Prevent promote inflammation released response responses restriction RNA RNA virus SARS SARS-CoV-2 stimulate subject Support the interferon tissue damage vesicular stomatitis virus viral entry viral growth Viral load viral replication virus VSV
[DOI] 10.1128/mBio.00584-21 PMC 바로가기 [Article Type] Research Article

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

항바이러스 약물 검사를 통해 DNA 손상 반응 억제제가 SARS-CoV-2 복제의 강력한 차단제임을 확인

Report

Published on 2021-03-182022-09-11
Journal: Cell Reports [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제,

[키워드] Abstract Anti-SARS-CoV-2 Activity antiviral activity Antiviral agents ATR ATR kinase berzosertib block blocked cell type cell types cellular cellular signaling pathway cellular signaling pathways clinical trials Compound compounds coronavirus Coronavirus replication CoV infection COVID-19 Critical Cytopathic effect DDR DNA-damage response pathway drug drug candidate effective epithelial cell epithelial cells exhibited Health Health crisis high-throughput screen highlight host-pathogen interactions human epithelial cells identify inhibited inhibiting inhibitor inhibitors involved Kinase inhibitor kinase inhibitors library MAPK mechanism MERS MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus modulate mTOR mTOR-PI3K-AKT pathway multiple coronaviruses nucleoside analogs Pathways PI3K precipitated Protein protein kinase protein kinase inhibitor protein kinase inhibitors provide Replication respiratory respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown signaling cascades signaling pathway signaling pathways Stage the SARS-CoV-2 therapeutic therapy Treatment treatment of COVID-19
[DOI] 10.1016/j.celrep.2021.108940 PMC 바로가기 [Article Type] Report

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article