Impacts of the COVID-19 pandemic on a human research islet programArticle Published on 2022-12-312023-07-08 Journal: Islets [Category] COVID19(2023년), [키워드] COVID-19 human islets Organ donation research islet distribution research islet isolation. SARS-CoV2 [DOI] 10.1080/19382014.2022.2047571 PMC 바로가기
Limited extent and consequences of pancreatic SARS-CoV-2 infectionArticle Published on 2022-02-212023-06-15 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 human coronaviruses human islets pancreas SARS-CoV-2 Type 1 diabetes type 2 diabetes viral infection [DOI] 10.1016/j.celrep.2022.110508 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces beta cell transdifferentiationSARS-CoV-2 감염은 베타 세포 전환분화를 유도합니다Clinical and Translational Report Published on 2021-08-032022-09-10 Journal: Cell Metabolism [Category] MERS, SARS, 치료기술, [키워드] Abstract acinar cell addition Alpha Antigen Autopsies Autopsy beta cell Beta cells cause Cell cell fate cell markers cellular cellular stress response chemokines Clinical data coronavirus disease Coronavirus disease 2019 correlation COVID-19 diabetes EgIF2 eIF2 example expression glucagon human islets immunostaining indicated individuals with COVID-19 induce Infection inhibitor insulin islet cell ISRIB lower expression pancreatic pancreatic islet Pathomechanism Pathomechanisms pathway phenotype provide PRSS1 recent reported reversed RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Single-cell RNA sequencing Stress stress response subject subjects suggested susceptible Trajectory analysis Tran trans trypsin 1 Viral Viral antigen [DOI] 10.1016/j.cmet.2021.05.015 PMC 바로가기 [Article Type] Clinical and Translational Report
Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic DonorsArticle Published on 2020-08-072022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 ACE2 expression ADAM17 adipose age binding BMI cells correlated COVID-19 diabete diabetes Diabetic diabetics Donor donors Endocrine entry of SARS-CoV-2 explain Express expression expression data expression level expression pattern female Gender Human human islets islet islets Microarray not affected occur pancreatic pancreatic islet pancreatic islets patients priming profile promote receptor required Revealed RNA-Seq RNA-sequencing S1 protein SARS-CoV-2 severity of COVID-19 significantly higher significantly increased statistically Symptom T2D the S protein thought tissue TMPRSS2 TMPRSS2 expression Variation viral spike [DOI] 10.3390/biology9080215 PMC 바로가기 [Article Type] Article