Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmissionArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration antibody approved Booster vaccine Combination Community consequence current Delta delta variant diagnosed dominant dominant variant Efficacy Evolution FDA higher infectivity human lung tissue immune Immune escape immune evasion Immunity immunocompromised individual IMPROVE Infection less monoclonal monoclonal antibodies Mutation mutations neutralising omicron Omicron variant other variant Protein public health recombination event reduced reduction reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants several variants severity Sotrovimab spike Spread syncytia formation the SARS-CoV-2 therapeutic use Transmission Vaccine variant variants of SARS-CoV-2 Wuhan-Hu-1 zoonotic [DOI] 10.1002/rmv.2381 PMC 바로가기
Replication of SARS-CoV-2 Omicron BA.2 variant in ex vivo cultures of the human upper and lower respiratory tractArticle Published on 2022-09-012022-11-16 Journal: EBioMedicine [Category] SARS, 변종, [키워드] airway antibody bronchial Bronchial tissue characterized China clinical manifestation Committee comparable Culture Delta delta variant disease severity Ex vivo explain explained Hong Kong human lung tissue immune evasion Infectious disease Lower respiratory tract lung lung tissue nasal nasal tissue observation omicron Omicron BA.2 parenchymal pathogenicity Patient Region replaced replicated Replication respiratory tissue SARS-CoV-2 strain Strains supported tested tissue Transmissibility Transmission university variant virus viruses wild-type wild-type virus [DOI] 10.1016/j.ebiom.2022.104232 PMC 바로가기
TRPC6 is altered in COVID-19 pneumoniaTRPC6은 COVID-19 폐렴에서 변경됩니다.Article Published on 2022-08-012022-09-11 Journal: Chemico-biological interactions [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggravate alveolar septa anatomical Capillaries cellular ciliated ciliated epithelium cough COVID COVID pneumonia COVID-19 COVID-19 pneumonia Dissection dissections distribution drugs Fever fibrosis Gene Expression Human human lung human lung tissue hyaline membrane hyaline membranes immunohistochemistry Inflammation inflammatory lesions inhibiting investigated involved lesions lung lung; molecular mechanism molecular mechanisms observation observations patients with COVID-19 Pneumonia pneumoniae processed Protein pulmonary inflammation reported Support Symptom target Therapies therapy tissue tissues TRP TRPC6 TRPC6 channels vessel wall was obtained [DOI] 10.1016/j.cbi.2022.109982 PMC 바로가기 [Article Type] Article
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection인간화 마우스는 SARS-CoV-2 감염 동안 인간 폐 조직 보호를 정의하는 대식세포가 풍부한 유전자 서명을 나타냅니다Article Published on 2022-04-192022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Antiviral antiviral responses cellular and molecular Clinical outcome composed COVID-19 CP: Immunology CP: Microbiology differentiation driven by fetal gene signature highlight histopathological Histopathology Human human immune response human immune responses to SARS-CoV-2 Human immune system human lung human lung tissue humanized humanized mice identify immune mechanism immune responses immunological mechanism immunology Infection knowledge lack lung Lung protection lung tissue Macrophage Macrophage infiltration Macrophage response macrophage responses macrophage responses to SARS-CoV-2 mice Microbiology mouse model Mouse models mouse models of SARS-CoV-2 pathway Phenotypes platform pulmonary immune responses. SARS-COV-2 infection severe inflammation signaling pathway tissue type I interferon upregulation [DOI] 10.1016/j.celrep.2022.110714 PMC 바로가기 [Article Type] Article
A computational and bioinformatic analysis of ACE2: an elucidation of its dual role in COVID-19 pathology and finding its associated partners as potential therapeutic targetsACE2의 컴퓨터 및 생물정보학 분석: COVID-19 병리학에서 ACE2의 이중 역할에 대한 설명 및 잠재적인 치료 표적으로서 관련 파트너 찾기Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting acute respiratory distress acute respiratory distress syndrome Acute respiratory distress syndrome Predicted ACE2 structure Analysis analyzed angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme -2 angiotensin-converting enzyme 2 ARDS bioinformatic analysis CDS Cell coding COVID-19 pandemic COVID-19 pathology determine Differentially expressed genes disease distress DNA sequence downregulation effort enzyme FOS FOXO4 FOXP2 healthy human lung tissue involved list low expression mechanism MiR-212-5p miRNA miRNA target miRNA targets miRNA-1246. pandemic pathological changes potential therapeutic target provide receptor respiratory distress Respiratory distress syndrome Spike protein Spread syndrome transcription factor transcription factors upregulation Vaccine viral entry viral spike protein [DOI] 10.1080/07391102.2020.1833760 PMC 바로가기 [Article Type] Article
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar MacrophagesResearch Article Published on 2022-02-082022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] AGER alveolar Alveolar macrophages amplification AT1 AT2 Autopsy caused Cell Cell culture cell line Cellular imaging coronavirus disease COVID-19 detection diagnostics Drug screening FFPE fixation fluorescent image analysis formalin Human human lung tissue human tissue identify infected patients infected with SARS-CoV-2 Infection Localization lung Lymph node macrophage marker Marco marker gene marker genes novel coronavirus SARS-CoV-2 observé ORF1a paraffin embedding pathology performed Placenta platform pneumocyte probe Region regions RNA RNA FISH SARS-CoV-2 SARS-CoV-2 RNA SFTPC Single Cell specimens subcellular subcellular localization subgenomic mRNAs tissue tissues Type viral life cycle Viral RNA widespread [DOI] 10.1128/mbio.03751-21 PMC 바로가기 [Article Type] Research Article
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가Research Article Published on 2022-01-132022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article
Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues자가포식 억제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스 및 이종이식 인간 폐 조직에서 폐렴을 개선합니다Article Published on 2021-11-232022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] 3-MA accompanied Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin animal model animal models anti-SARS-CoV-2 therapeutics Atg13 ATG14 Atg5 autophagic autophagy autophagy-inhibiting agent autophagy-inhibiting agents block caused Combination complex complexes contribute coronavirus Crab-eating macaque Critical elements enzyme events experimental evidence global pandemic hACE2 Huh-7 cells Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung human lung tissue IMPROVE in vitro in vivo induce Infection inhibit inhibition insight interfere involved mechanism mice modulation mouse mTOR pathway Pneumonia potential therapeutic target potential therapeutic targets SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppresse therapeutic agent therapeutic agents thought tissues transgenic mice Transgenic mouse Vero E6 virus infection Virus-host interaction Virus-host interactions Vps34 [DOI] 10.1128/JVI.01537-21 PMC 바로가기 [Article Type] Article