Comparative genome analysis reveals driving forces behind Monkeypox virus evolution and sheds light on the role of ATC trinucleotide motifResearch Article Published on 2024-05-182024-09-05 Journal: Virus Evolution [Category] update2024, [키워드] human pathogen Microsatellite Monkeypox motifs repeats [DOI] 10.1093/ve/veae043 PMC 바로가기 [Article Type] Research Article
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 InfectionArticle Published on 2022-10-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation Vaccine vaccine candidate vaccine candidates vaccine for COVID-19 viral disease viral evolution virus viruses [DOI] 10.1007/s10753-022-01651-y PMC 바로가기
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccinesArticle Published on 2022-09-222022-11-15 Journal: PLoS Pathogens [Category] SARS, 진단, [키워드] acute respiratory syndrome Asia bat bats Cell cell entry circulating COVID-19 pandemic Cross reactivity engage facilitate Health host cell Human human ACE2 human cells human pathogen identify individual infect Invasion Lineage majority monoclonal antibody outbreak pseudotype RBD receptor Receptor binding domain sarbecovirus SARS-CoV SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine serological serum tested the RBD Vaccine virus while [DOI] 10.1371/journal.ppat.1010828 PMC 바로가기
Case report: Green nail syndrome in an epidemic prevention volunteer during the outbreak of the Omicron in ShanghaiArticle Published on 2022-09-202022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Affect cause caused characterized colonize cured disorder Epidemic epidemic prevention volunteer GNS green green nail syndrome human pathogen information omicron organism outbreak Patient Personal protective equipment prolonged exposure Protective clothing protective clothing. Pseudomona Pseudomonas aeruginosa receiving reported Shanghai syndrome the patient the SARS-CoV-2 Treatment variant [DOI] 10.3389/fpubh.2022.1009517 PMC 바로가기
Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and wastewater: What does it mean for non-human primates?SARS-CoV-2와 폐수: 인간이 아닌 영장류에게 어떤 의미가 있습니까?Article Published on 2022-05-012022-09-11 Journal: American journal of primatology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected approach best changed Contact contracting the virus coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 disease disease transmission Evidence genetic susceptibility global pandemic help Human human pathogen Infection monkeys NHP NHPs non-human primate non-human primates Novel coronavirus novel coronavirus disease occurred one health Outbreaks pandemic Pathogens predict processing PROTECT recent researchers respiratory resulting risk risk of transmission SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread susceptibility susceptible synanthropic primates Transmission transmission of disease unique Viral Viral RNA virus wastewater zoonosis zoos [DOI] 10.1002/ajp.23340 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 RNA in Bivalve Mollusks by Droplet Digital RT-PCR (dd RT-PCR)Droplet Digital RT-PCR(dd RT-PCR)에 의한 이매패류 연체동물의 SARS-CoV-2 RNA 검출Article Published on 2022-01-142022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 치료기술, [키워드] Alpha Alpha variant approach assays B.1.1.7 bivalve Campania characteristic collected Concentration COVID-19 detectable detection Digital displaying droplet feces FIVE human pathogen impacted infected patient infected patients Lineage Lineage B.1.1.7 median Mollusk MONITOR Mutation nsp14 outbreak Partial Pathogens PCR positive sample Prevalence real-time RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Sequencing shellfish tested variant Viral virus was obtained wastewater water water bodies water body waters [DOI] 10.3390/ijerph19020943 PMC 바로가기 [Article Type] Article
Recapitulating Trafficking of Nucleosides Into the Active Site of Polymerases of RNA Viruses: The Challenge and the PrizeMedical Technology Published on 2021-12-142022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] antiviral agent approach approved cause cellular challenge classical Compound computational approach coronavirus COVID-19 pandemic curative treatment described docking early stage effective Flaviviridae HCV Hepatitis hepatitis C virus hepatitis C virus (HCV) human pathogen inhibitor metabolite molecular dynamics simulations NS5B Nsp12 NTP nucleoside nucleoside analog nucleoside analog drugs nucleotide polymerase Prize protocol RdRP RdRps RNA RNA virus RNA-dependent RNA polymerase SARS-CoV-2 Site sofosbuvir Still therapy viral infections viruses Zika [DOI] 10.3389/fmedt.2021.705875 PMC 바로가기 [Article Type] Medical Technology
Hyperhemolysis in the Setting of Mixed-Autoimmune Hemolytic Anemia: A Rare Complication of COVID-19Allergy/Immunology Published on 2021-12-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 48 hours abnormality acute respiratory syndrome addition Admission antibodies antiglobulin test autoantibodies Autoimmune autoimmune hemolytic anemia (aiha) Blood Cell Complication coronavirus COVID 19 COVID-19 described develop dropped explain hematological hemolytic hemolytic anemia Hgb hospital human pathogen hyperhemolysis syndrome IgG immune thrombocytopenia purpura Immune thrombocytopenic purpura indirect bilirubin infected with SARS-CoV-2 jaundice LDH majority male mechanism mixed autoimmune hemolytic anemia past medical history Patient PCR positive required resolved Respiratory system SARS-CoV-2 setting Seven Symptom tested unique virus warm [DOI] 10.7759/cureus.20356 PMC 바로가기 [Article Type] Allergy/Immunology