hyper-inflammatory response – Communicable Diseases Research

A novel platform for attenuating immune hyperactivity using EXO-CD24 in COVID-19 and beyond

Article

Published on 2022-09-072022-10-06
Journal: EMBO Molecular Medicine [Category] 진단,

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

COVID-19를 가진 입원 환자의 염증성 바이오 마커 프로파일 및 환자의 결과와의 연관성 : 단일 중심 연구

Research Article

Published on 2021-12-022022-09-10
Journal: PLoS ONE [Category] 바이오마커,

[키워드] Absolute lymphocyte count acute respiratory distress acute respiratory distress syndrome addition Admission ALC Analysis ARDS association C-reactive protein classical Clinical characteristics Clinical course Clinical outcome Cohort correlation count COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity Critical CRP D-dimer death direction disease disease severity Dubai ferritin help hospitalized patient hyper-inflammatory response ICU ICU admission IMPROVE incidence Infection Inflammation Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Injury intensive care intensive care unit investigated Kuwait laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH lymphocyte lymphopenia marker multiple organs dysfunction neutrophil Neutrophils organ outcome pandemic Pathogenesis Patient patient cohort patient’s death PCT predict Predictive Predictive value procalcitonin resource respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 Stratification syndrome the disease the patient Therapeutic approach triggered turn Ventilation ventilator virus WBC white cell with COVID-19
[DOI] 10.1371/journal.pone.0260537 PMC 바로가기 [Article Type] Research Article

Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones

COVID-19의 면역 내분비학: 성 호르몬의 주요 역할

Review

Published on 2021-12-022022-09-11
Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘,

[키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial
[DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review

Intravenous immunoglobulins for the treatment of the hyper-inflammatory response in COVID-19. Another failure of immunomodulatory therapy?

COVID-19의 과염증 반응 치료를 위한 정맥 면역글로불린. 면역 조절 요법의 또 다른 실패?

Article

Published on 2021-10-012022-09-12
Journal: Clinical microbiology and infection : the official [Category] MERS, 진단,

[키워드] Abstract COVID-19 hyper-inflammatory response Immunoglobulin immunoglobulins immunomodulation immunomodulatory SARS-CoV-2 Treatment
[DOI] 10.1016/j.cmi.2021.07.012 PMC 바로가기 [Article Type] Article

Platelet-driven coagulopathy in COVID-19 patients: in comparison to seasonal influenza cases

Research

Published on 2021-05-312022-10-31
Journal: Experimental Hematology & Oncology [Category] COVID-19,

[키워드] activated addition Administered analyzed Anticoagulant Anticoagulants bleeding Blood bronchitis cardiovascular diseases Characteristics Coagulation coagulation disorder Coagulopathy Cohort cohorts Comorbidities coronavirus disease COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients D-dimer level demographic data demonstrated diabetes disease severity fibrinogen hematological Hospital admission hyper-inflammatory response Hyperreactivity incidence Influenza influenza infection INR intensive care unit Leukocytosis lymphocytopenia male mechanism median age medications Mortality pandemic Patient profile Prothrombin time provide reported Result SARS-CoV-2 SARS-CoV-2 pathogenesis Seasonal influenza separated severe COVID-19 patient supplementary material therapeutic thrombin Treatment
[DOI] 10.1186/s40164-021-00228-z PMC 바로가기 [Article Type] Research

Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review

Review

Published on 2021-04-172022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

[키워드] ACE2 acute respiratory distress angiotensin-converting enzyme 2 ARDS Blood coagulation chronic inflammation Clinical finding Coagulopathy Complication complications consequence contribute COVID-19 COVID-19 disease severity Cytokine storm disease severity elevated explain facilitated Factor feature ferritin level hemorrhage hyper-inflammatory response impaired viral clearance Inflammation insulin Leptin mechanism obesity Patient potential mechanism Prevalence preventive measure progression receptors review risk risk factor SARS-CoV-2 SARS-COV-2 infection second severe COVID-19 Signaling syndrome therapeutic intervention thrombus formation understanding upregulation viral entry
[DOI] 10.3390/cells10040933 PMC 바로가기 [Article Type] Review

Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis

Article

Published on 2021-04-132022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

[키워드] 105 patient Absolute lymphocyte count absolute neutrophil count ALC ANC association C-reactive protein characterized Clinical course Clinical outcome Clustering Clustering analysis Clusters Cohort COVID-19 COVID-19 patient CRP CRP level CRP levels determine died elevated hospitalized COVID-19 patient hyper-inflammatory immune response hyper-inflammatory response identify immune response IMPROVE independent Inflammation inflammatory immune response Inflammatory response lymphopenia outcome oxygen support Patient patients pattern required Respiratory tract diseases retrieved severe disease supplementary oxygen three groups validation cohort was used were assessed
[DOI] 10.1038/s41598-021-87668-z PMC 바로가기 [Article Type] Article

mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection

mRNA-lncRNA 공동 발현 네트워크 분석, 심각한 SARS-CoV-2 감염 시 면역 기능 장애에서 lncRNA의 역할 밝혀

Article

Published on 2021-03-032022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] Activation addition affected analyzed anti-viral response anti-viral responses BALF Bronchoalveolar lavage fluid Clinical features co-expression network co-expression network analysis correlated COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients critical COVID-19 patients cytokine cytokine signaling Cytokine storm Cytokine storms Cytokines differentially expressed epithelial cell epithelial cell line expression Factor global public health Host human lung human lung epithelial cell lines hyper-inflammatory response Hyper-inflammatory responses immune response immune responses Infection involved lncRNA long non-coding RNA Lungs molecular interaction molecular mechanism network neutrophilia non-coding RNA pathway Patient patients plasma pro-inflammatory cytokine pro-inflammatory cytokines required respiratory respiratory disorder responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 virus Sepsis Sequencing severe SARS severe SARS-CoV-2 specimen the cytokine storm Transcriptome transcriptome sequencing with COVID-19
[DOI] 10.3390/v13030402 PMC 바로가기 [Article Type] Article

Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease

숙주 스핑고지질: COVID-19 질병 관리를 위한 SARS-CoV-2 감염 제어를 위한 관점 면역 보조제

Review

Published on 2021-02-012022-09-11
Journal: Prostaglandins & other lipid mediators [Category] SARS, 신약개발, 치료제,

[키워드] Activation Antigen presentation Antiviral approach autophagy Bacterial infections ceramide clearance COVID 19 COVID-19 cases COVID-19 disease COVID-19 infection COVID-19 patients derivative effector immune response enzyme II epithelial cell epithelial cells expected Features fibrosis fingolimod FTY720 Host host-pathogen interactions human diseases hyper-inflammatory response Hyper-inflammatory responses IL-6 immune Immune adjuvants immune responses immunosuppressive Infection involved Lipid Lyase M1/M2 macrophages macrophages membrane-bound modulate Pathogenesis pathological outcomes pathological response phosphate promote receptor Replication respiratory SARS-CoV-2 SARS-COV-2 infection Signaling sphingolipid sphingolipids sphingosine-1-phosphate symptomatic T cell T cell response Th1 Th1 effector response.
[DOI] 10.1016/j.prostaglandins.2020.106504 PMC 바로가기 [Article Type] Review

High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response

고용량 코르티코스테로이드 펄스 요법은 과염증 반응의 위험이 있는 COVID-19 환자의 생존율을 증가시킵니다

Research Article

Published on 2021-01-282022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19,

[키워드] Analysis C-reactive protein can be used carried co-morbidities co-morbidity Corticosteroid corticosteroid pulse Course COVID-19 COVID-19 patient D-dimer decrease decreased mortality determine Dexamethasone Diagnostic Criteria effective intervention Efficacy ferritin following Future HDCPT High dose high dose corticosteroid pulse therapy hyper-inflammatory response identify IL-6 inclusion criteria increase increased survival initial Laboratory Lactate lactate dehydrogenase marker Methylprednisolone morbidities Mortality multivariate Cox regression Non-survivors objective observational study parameter Patient patients pro-inflammatory pro-inflammatory markers prospective observational study randomized clinical trial RCT Result risk statistically significant Stratification survival rate survival rates survivor Test the patient Therapies therapy to define treated
[DOI] 10.1371/journal.pone.0243964 PMC 바로가기 [Article Type] Research Article