Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)-rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipientsArticle Published on 2022-09-152022-11-15 Journal: Trials [Category] SARS, 진단, [키워드] 1:1 binding domain Booster vaccine cell-mediated response clinical Controlled trial COVID COVID-19 COVID-19 vaccination COVID-19 vaccine death develop disease severity dose Effectiveness Efficacy ENhance hospitalisation humoral hypothesise IgG immune cell population immunological Immunosuppression IMPROVE include increased risk Intervention kidney transplant recipient kidney transplant recipients Kidney transplantation live SARS-CoV-2 Modification mTOR inhibitor multicentre neutralisation New outcome participant Prednisolone Primary outcome proportion Protective protective immunity public health randomised randomised controlled trial Rapamycin recipient reduce reduced regimen registry responses SARS-CoV-2 SARS-CoV-2 vaccine secondary serological Sirolimus Standard of care Study protocol Tolerability Trial vaccination Vaccine vaccine response virus [DOI] 10.1186/s13063-022-06634-w PMC 바로가기
Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In VitroME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다Article Published on 2022-08-022022-09-11 Journal: Cells [Category] 바이오마커, [키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while [DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article
Lower levels of glutathione in the anterior cingulate cortex associate with depressive symptoms and white matter hyperintensities in COVID-19 survivorsShort communication Published on 2022-08-012022-10-05 Journal: European neuropsychopharmacology : the journal of [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Affect age alteration antioxidant association Blood Brain brain involvement clinical manifestation Concentration COVID-19 Depression depression score depressive depressive symptom Depressive symptoms glutathione GSH hypothesise implicated Infection Lower magnetic resonance imaging Neurological symptoms Novel coronavirus outcome overlapping oxidative stress participant predicted reduced reported Respiratory system SARS-CoV-2 SARS-COV-2 infection severity shown Spectroscopy survivor Survivors Symptom syndrome systemic inflammation Volume White matter [DOI] 10.1016/j.euroneuro.2022.06.008 [Article Type] Short communication
Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections변경된 서브게놈 RNA 풍부도는 SARS-CoV-2 B.1.1.7/알파 변이체 감염에 대한 독특한 통찰력을 제공합니다Article Published on 2022-07-052022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, [키워드] Alpha Altered Antibody neutralization Applying ARTIC Network B.1.1.7 B.1.1.7 lineage B.1.177 Biology clinical samples Clinical severity complementary creating cycle threshold discontinuous transcription dominant lineage evaluate genomic genomic reads genomic sequencing greater hypothesise in vitro increase in independent independent of Infection Lineage lineages median Mutation nucleocapsid nucleotide Orf9b Oxford Nanopore Technology periscope positive produced profile protein level provide reductions in RNA sampling SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 infections sequence sgRNA significantly increased Support symptom onset the SARS-CoV-2 genome Transcription unique variant variants of concern virus [DOI] 10.1038/s42003-022-03565-9 PMC 바로가기 [Article Type] Article
Protocol for a prospective quasi-experimental study on SARS-CoV-2 transmission during outdoor sports events in France: the COVID-ESO project프랑스 야외 스포츠 행사 중 SARS-CoV-2 전염에 대한 전향적 준실험 연구 프로토콜: COVID-ESO 프로젝트Article Published on 2022-06-162022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 변종, [키워드] 1:1 activities adjusted age analysed analyzed approved asked assigned both group both groups circulation clinical Clinical research Committee Community conducted confounders Contamination control group Cycling DES difference District eligible email Epidemiology Ethical approval ethical committee Ethics event events finding France General population Health higher risk hypothesise individual logistic regression model measure meta-analyses National protocol questionnaire reference number Research residence respiratory respiratory infections risk saliva test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Sex Sociodemographic South Sports Medicine Spread Transmission Trial variant virus West [DOI] 10.1136/bmjopen-2021-055927 PMC 바로가기 [Article Type] Article
Group Clinical Supervision for midwives and burnout: a cluster randomized controlled trialRandomized Controlled Trial Published on 2022-04-112022-10-05 Journal: BMC Pregnancy and Childbirth [Category] 임상, [키워드] approach Burnout Care clinical Clinical supervision Cluster Cluster randomised controlled trial Complete COVID 19 Culture determine dose ENhance exacerbated facilitated group healthcare hypothesise implication Intention Intervention inventory less Midwifery outcome outcomes pandemic physically positive psychologically randomised controlled randomised controlled trial Randomized controlled trial receive recruited registration number Research secondary sick supervision Support women Workplace Workplace culture. [DOI] 10.1186/s12884-022-04657-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pandemic inequalities: emerging infectious diseases and health equityCommentary Published on 2022-01-142022-10-29 Journal: International journal for equity in health [Category] Coronavirus, SARS, [키워드] coronavirus COVID-19 disease Disparities Drawing Ebola equity event Frequency Health hypothesise Infectious disease less Mortality Outbreaks pandemic Pandemics pathway Prevalence public health reduce Research shown social determinants of health Socio-economic Spread susceptibility Symptom Transmission Treatment Zika zoonotic [DOI] 10.1186/s12939-021-01611-2 PMC 바로가기 [Article Type] Commentary
Magnitude of optimal adherence and predictors for a low level of adherence among HIV/AIDS-infected adults in South Gondar zone, Northwest Ethiopia: a multifacility cross-sectional studyObservational Study Published on 2022-01-032022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] 95% CI adherent adjusted adverse events AIDS Analysis antiretroviral Antiretroviral therapy ART CD4 cell Compliance conducted COVID-19 cross-sectional determinant drug drugs Factor Factors healthcare highly active HIV HIV & HIV/AIDS hospital hypothesise identify IMPROVE initiation of treatment Intervention less Level Local Logistic regression participant participated Patient predictor public health Public Hospital quality in healthcare receiving reduce regimens secondary outcome selected significantly South stage III Study participants Treatment Tuberculosis WHO zone [DOI] 10.1136/bmjopen-2021-056009 PMC 바로가기 [Article Type] Observational Study
Protective potential of high-intensity interval training on cardiac structure and function after COVID-19: protocol and statistical analysis plan for an investigator-blinded randomised controlled trialCOVID-19 이후 심장 구조 및 기능에 대한 고강도 인터벌 트레이닝의 보호 가능성: 조사자 맹검 무작위 대조 시험을 위한 프로토콜 및 통계 분석 계획Article Published on 2021-11-182022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 Anti-inflammatory effects approved Capital Capital Region cardiac injury cardiac mass Cardiology Cardiopulmonary cardiorespiratory cardiorespiratory fitness changes in Committee control group COVID-19 Denmark discharged Ethics hospital Hypothesis hypothesise hypothesised IMPROVE Inconclusive Injury interval training Intervention life Lung function morbidity peer-reviewed positive protocol Quality of life randomised randomised controlled trial reduce reducing Region Registered registration number Safe Sex Sports Medicine standard care Statistical analysis plan survivor Symptom systemic inflammatory response Trial Registration Number [DOI] 10.1136/bmjopen-2020-048281 PMC 바로가기 [Article Type] Article
How does English national end-of-life care policy impact on the experience of older people at the end of life? Findings from a realist evaluationResearch Article Published on 2021-10-272022-10-28 Journal: Primary Health Care Research & Development [Category] Coronavirus, MERS, SARS, [키워드] Analysis appear Care death disease driven by Effectiveness end of life care England English Factor finding good quality groups Health helping highlight hypothesise impacted influence lack Local mechanism National national policy observation Older outcomes pandemic Patient Patient experience qualitative research Realist evaluation receiving resource reveal rising significantly subsequent tension [DOI] 10.1017/S1463423621000621 PMC 바로가기 [Article Type] Research Article