ROX Index Variation as a Predictor of Outcomes in COVID-19 PatientsArticle Published on 2024-05-212024-09-05 Journal: Journal of Clinical Medicine [Category] update2024, [키워드] COVID-19 High-flow nasal cannula Hypoxemic respiratory failure intubation low resource settings prediction tools ROX index [DOI] 10.3390/jcm13113025 PMC 바로가기 [Article Type] Article
Regional moderate hyperthermia for mild-to-moderate COVID-19 (TherMoCoV study): a randomized controlled trialMedicine Clinical Trial Published on 2023-12-222024-09-05 Journal: Frontiers in Medicine [Category] update2024, [키워드] COVID-19 Hypoxemic respiratory failure non-oncologic applications of hyperthermia SARS-CoV-2 thermotherapy [DOI] 10.3389/fmed.2023.1256197 PMC 바로가기 [Article Type] Medicine Clinical Trial
The role of prone positioning in patients with SARS-CoV-2-related respiratory failure in non–intensive care unitOriginal Research Published on 2023-04-272024-09-05 Journal: Therapeutic Advances in Respiratory Disease [Category] update2024, [키워드] ARDS COVID-19 Hypoxemic respiratory failure non-invasive mechanical ventilation prone positioning SARS-CoV2 [DOI] 10.1177/17534666231164536 PMC 바로가기 [Article Type] Original Research
Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohortsarticle Published on 2023-02-222024-09-05 Journal: Critical Care [Category] update2024, [키워드] Bayesian analysis Hypoxemic respiratory failure Intensive care medicine mechanical ventilation Noninvasive ventilation Statistical methods Target trial emulation Thresholds for invasive ventilation [DOI] 10.1186/s13054-023-04307-x PMC 바로가기 [Article Type] article
The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19INVENT COVID 시험: COVID-19에 의해 유발된 급성 호흡곤란 증후군이 있는 피험자를 대상으로 정맥 이마티닙 메실레이트(Impentri®)의 효능과 안전성을 조사하는 무작위 대조 시험을 위한 구조화된 프로토콜Study Protocol Published on 2022-02-162022-09-10 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 1:1 28-day mortality acute respiratory distress acute respiratory distress syndrome Admission ARDS Berlin criteria bis in die Chain Reaction changes in characterized clinical trial coronavirus disease Coronavirus disease 2019 COVID COVID-19 death decrease demonstrated discharge disease severity double-blind edema Efficacy and safety endothelial Endothelial dysfunction Estimated Extravascular lung water hypoxemic Hypoxemic respiratory failure ICU Imatinib imatinib mesylate immune response include increase in index Inflammation inflammatory conditions inhibitor intensive care intensive care unit intravenous Invasive mechanical ventilation IV infusion Kinase inhibitor life-threatening lung Lungs mechanical ventilation mechanically ventilated mesylate moderate-severe Mortality multicenter Older outcome Oxygenation pandemic parallel-group parameter parameters participant pharmacokinetics Placebo placebo-controlled polymerase chain polymerase chain reaction positive Prevent protocol Pulmonary edema randomization Randomized Randomized controlled trial recruitment reduce reduction in reflected respiratory distress Respiratory failure SARS-CoV2 secondary study period subject syndrome therapy Tolerability Trial registration tyrosine tyrosine kinase inhibitor Vascular vascular permeability Ventilation ventilator-free day Ventilator-free days water widespread [DOI] 10.1186/s13063-022-06055-9 PMC 바로가기 [Article Type] Study Protocol
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial급성 저산소성 호흡부전 및 COVID-19 환자의 삽관 또는 사망에 대한 비침습적 호흡 전략의 영향: RECOVERY-RS 무작위 임상 시험Randomized Controlled Trial Published on 2022-02-082022-09-11 Journal: JAMA [Category] 유전자 메커니즘, 임상, [키워드] absolute difference Acute hypoxemic respiratory failure adaptive Adult patient Adult patients Adverse adverse events age Care clinical Clinical outcome clinical outcomes clinical trial Composite conducted Continuous Continuous Positive Airway Pressure COVID-19 COVID-19 case CPAP crossover declining determine Effect Effectiveness event failure Follow-up group HFNO High-flow nasal oxygen hospital Hospitalized hospitalized patient hospitalized patients hypoxemic Hypoxemic respiratory failure IMPROVE initial Intervention intubation Mortality no significant difference noninvasive respiratory not significantly different occurred outcome oxygen Oxygen therapy parallel group participant Participants Patient patients with COVID-19 positive airway pressure Primary outcome Randomized randomized clinical trial randomized patient receive recruitment reduced respiratory Respiratory failure risk significantly significantly lower Strategy tracheal tracheal intubation Trial Uncertainty white [DOI] 10.1001/jama.2022.0028 PMC 바로가기 [Article Type] Randomized Controlled Trial
Helmet noninvasive ventilation for COVID-19 patients (Helmet-COVID): statistical analysis plan for a randomized controlled trial코로나19 환자를 위한 헬멧 비침습적 환기(Helmet-COVID): 무작위 대조 시험을 위한 통계 분석 계획Randomized Controlled Trial Published on 2022-02-022022-09-10 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, [키워드] 28-day mortality 95% confidence interval Acute hypoxemic respiratory failure Analysis arterial oxygen partial pressure chi-square test coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients death detect Effectiveness enrolled Enrollment expected flow rate fraction Helmet noninvasive ventilation High-flow nasal oxygen hypoxemic Hypoxemic respiratory failure ICU patient include Intention intention-to-treat Kuwait Local multicenter Noninvasive ventilation oxygen oxygen partial pressure oxygen support Oxygen therapy partial pressure Patient Primary outcome randomization Randomized Randomized controlled trial randomized trial Relative risk reported respiratory Respiratory failure Respiratory Support Result risk reduction Saudi Arabia standard oxygen therapy Statistical analysis plan supplemental oxygen supplementary material Trial Trial registration usual care usual care alone usual care group [DOI] 10.1186/s13063-021-05988-x PMC 바로가기 [Article Type] Randomized Controlled Trial
Hypersensitivity may be involved in severe COVID-19과민증은 심각한 COVID-19에 관련될 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Clinical and experimental allergy : journal of the [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] activated AhR airway analysed anti-SARS-CoV-2 Anti-SARS-CoV-2 specific IgE antibodies cell activation Clinical severity conducted coronavirus disease Coronavirus disease 2019 correlated Corticosteroid Corticosteroids COVID-19 detect Early convalescence endoscopy Evidence evidence of histological hypersensitivity hypersensitivity reactions hypoxemic Hypoxemic respiratory failure IgE IgE-mediated hypersensitivity reactions inflammatory storm intestinal tissues involved lung mast cell Mast cells mechanism Methylprednisolone Methylprednisolone therapy nucleocapsid nucleocapsid protein PaO Pathogenesis positive Protein provocation test pulmonary Pulmonary function test pulse pulse methylprednisolone therapy Respiratory failure S1 protein serum Serum level severe cases severe COVID-19 Severity Score significantly higher [DOI] 10.1111/cea.14023 PMC 바로가기 [Article Type] Article
Euglycemic Diabetic Ketoacidosis in a Pregnant Woman With Severe COVID-19: A Case ReportEndocrinology/Diabetes/Metabolism Published on 2022-01-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Complication coronavirus disease COVID-19 Diabetic diabetic ketoacidosis euglycemic exacerbated fetal gestational diabete healthcare hospital Hypoxemic respiratory failure Infection initiated ketoacidosis management mechanical ventilation MONITOR pandemic physiological state Pregnancy Pregnant woman pregnant women presenting protocol report Severe COVID-19 Infection Stressor substantial risk the patient Treatment Ventilation was performed with COVID-19 woman women [DOI] 10.7759/cureus.21649 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Noninvasive respiratory support for COVID-19 patients: when, for whom, and how?Review Published on 2022-01-152022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress syndrome (ARDS) Acute respiratory failure (ARF) addition advanced disease Algorithm Analysis Continuous positive airway pressure (CPAP) contraindication COPD COVID-19 COVID-19 patient COVID-19 patients CPAP disease Effect etiology H1N1 HCW healthcare worker HFNC High flow nasal cannula (HFNC) Hypoxemic respiratory failure IMV include indication intubation Invasive mechanical ventilation Invasive mechanical ventilation (IMV) lung MERS mild respiratory mortality rate NIRS NIV noninvasive respiratory Noninvasive respiratory support (NIRS) Noninvasive ventilation (NIV) outcome outcomes Pandemics Patient patient selection Potential treatment predictor Protective Pulmonary edema question recommendations reduce Research resource Respiratory failure Respiratory mechanics Respiratory Support risk SARS Self-Inflicted Lung Injury severe COVID-19 supplementary material Support Ventilation ventilator virus worsening [DOI] 10.1186/s40560-021-00593-1 PMC 바로가기 [Article Type] Review