A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)SARS-CoV-2(COVID-19)에 감염되어 침습적 기계 환기 없이 병원에 입원한 환자에서 이카티반트의 효능과 안전성을 평가하기 위한 다기관, 공개 라벨, 무작위, 개념 증명 II상 임상 시험: 연구 프로토콜(ICAT-COVID)Article Published on 2022-04-122022-09-11 Journal: Trials [Category] [DOI] 10.1186/s13063-022-06219-7 PMC 바로가기 [Article Type] Article
How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법Review Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] [DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소Original Article Published on 2022-03-052022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] [DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article
Bradykinin-target therapies in SARS-CoV-2 infection: current evidence and perspectivesSARS-CoV-2 감염의 브래디키닌 표적 요법: 현재 증거 및 전망Review Published on 2022-03-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] [DOI] 10.1007/s00210-022-02206-6 PMC 바로가기 [Article Type] Review
Icatibant in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Case ReportCase Reports Published on 2021-10-252023-07-13 Journal: Journal of investigational allergology & clinical immunology [Category] [DOI] 10.18176/jiaci.0659 PMC 바로가기 [Article Type] Case Reports
Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19중증 COVID-19에서 키닌-칼리크레인 시스템의 약리학적 억제와 관련된 안전성 및 결과Article Published on 2021-02-162022-09-10 Journal: Viruses [Category] [DOI] 10.3390/v13020309 PMC 바로가기 [Article Type] Article
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial중증 코로나19 환자에서 이카티반트 및 C1 에스테라제/칼리크레인 억제제의 효능 및 안전성 평가: 3군 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-01-202022-09-10 Journal: Trials [Category] [DOI] 10.1186/s13063-021-05027-9 PMC 바로가기 [Article Type] Study Protocol
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndromeShort Report Published on 2020-04-272022-10-31 Journal: eLife [Category] [DOI] 10.7554/eLife.57555 PMC 바로가기 [Article Type] Short Report