Voltammetric sensor for COVID-19 drug Molnupiravir on modified glassy carbon electrode with electrochemically reduced graphene oxideResearch article Published on 2022-09-012022-10-05 Journal: Journal of Electroanalytical Chemistry [Category] 치료제, [키워드] Accuracy Analysis applied buffer characterized Concentration Council COVID-19 Detection limit Electrochemical sensor electron evaluated examined exhibited ICH linear molnupiravir parameter parameters Precision proton quantification Quantitative analysis reduced Reduced graphene oxide sensitivity stability transferred validation was measured [DOI] 10.1016/j.jelechem.2022.116579 [Article Type] Research article
Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial계층적 복합 종점을 기반으로 한 연구의 설계 및 분석: DARE-19 시험의 통찰력Article Published on 2022-09-012022-09-11 Journal: Therapeutic innovation & regulatory science [Category] 임상, [키워드] accompanied Analysis analyzed cardiometabolic Cardiometabolic risk factors clinical endpoint Clinical endpoints Clinical outcome clinical outcomes clinically component components Composite composite endpoint COVID-19 COVID-19 pneumonia Dapagliflozin described detectable disease Effect Endpoint example flexible handling Hierarchical composite endpoints hospitalized patient hospitalized patients ICH include inhibitor insight Interpretation mechanism mechanism of action Missing data offered Pneumonia power primary endpoints randomized trial ranking Sample size SGLT2 inhibitors statistical suggested the primary endpoint therapeutic to define Treatment Trial Win odds. with COVID-19 [DOI] 10.1007/s43441-022-00420-1 PMC 바로가기 [Article Type] Article
Imaging features and ultraearly hematoma growth in intracerebral hemorrhage associated with COVID-19COVID-19와 관련된 뇌내 출혈의 영상 특징 및 초초기 혈종 성장Multicenter Study Published on 2022-07-012022-09-11 Journal: Neuroradiology [Category] MERS, 바이오마커, [키워드] Analysis analyzed anticoagulant therapy Anticoagulant treatment antiplatelet antithrombotic therapy association baseline bleeding Case-control Characteristics characterized clinical Computed tomography confounding factor confounding factors Control COVID-19 COVID-19 disease COVID-19 patient defined demographic demographic characteristics disease exclusion feature growth hematoma hemorrhage heterogeneous hypodensity ICH imaging Intracerebral hemorrhage Laboratory Linear regression marker mechanisms median multicenter multifocal multivariable outcome Patient patients with COVID-19 predictor remained Research retrospective risk factor SARS-CoV-2 severity of COVID-19 significantly higher significantly more stroke Systolic blood pressure two groups Vascular Volume were recorded with COVID-19 [DOI] 10.1007/s00234-021-02861-1 PMC 바로가기 [Article Type] Multicenter Study
A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
Development of Improved High-Performance Liquid Chromatography Method for the Determination of Residual Caprylic Acid in Formulations of Human ImmunoglobulinsArticle Published on 2022-03-032022-10-30 Journal: Molecules [Category] Coronavirus, MERS, SARS, [키워드] 1:1 acid Analysis anti-SARS-CoV-2 applied caprylic acid Chromatography component convalescent convalescent anti-SARS-CoV-2 human plasma demonstrated Determination development factorial design Formulation fraction high-performance liquid chromatography method Human human immunoglobulin human immunoglobulins Human plasma ICH immunoglobulins Improved Laboratory linear liquid parameter preserved produced Quality Quality control quantification residual stationary supernatant therapeutic use validation was performed [DOI] 10.3390/molecules27051665 PMC 바로가기 [Article Type] Article
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article
Development and Validation of a Novel HPLC Method to Analyse Metabolic Reaction Products Catalysed by the CYP3A2 Isoform: In Vitro Inhibition of CYP3A2 Enzyme Activity by Aspirin (Drugs Often Used Together in COVID-19 Treatment)Article Published on 2022-01-292022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] 6β-hydroxydexamethasone Accuracy activity applied Aspirin bridge Chromatography competitive inhibitor Concentration COVID-19 CYP3A activity CYP3A2 cytochrome P450 development Dexamethasone drug drug interaction enzyme activity evaluate Fever harmonization healthcare HPLC ICH in vitro indicated Inflammation inhibit inhibition inhibitor International Conference limit limit of detection liquid liver metabolic moderate novel Pain Precision product quantification reaction reversed risk Severe case stability Toxicity treat validation [DOI] 10.3390/molecules27030927 PMC 바로가기 [Article Type] Article
COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled AnalysisArticle Published on 2022-01-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Analysis anticoagulation assumption Clinical characteristics Cohort collected Complication complications contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical Critically ill database diagnosed with COVID-19 ECMO hemorrhage Hemorrhagic Hemostasis heterogeneous ICH Impact Intracranial intracranial hemorrhage item literature review median age Mortality Pathomechanism pathophysiological Patient patients performed poor prognosis Prevalence Prognosis radiological Reporting review SARS-CoV2 selection process Series subtype Subtypes Support systematic review the patient thromboembolic [DOI] 10.3390/jcm11030605 PMC 바로가기 [Article Type] Article
Age-Related Risk Factors and Complications of Patients With COVID-19: A Population-Based Retrospective StudyMedicine Published on 2022-01-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] affected age alcohol Analysis arrhythmia Arrhythmias association bleeding Cancer Chronic kidney disease city CKD Clinical characteristics clinical manifestations Comorbidity Complication complications coronavirus disease Coronavirus disease 2019 correlation Correlation analysis COVID-19 death Deceased diabete died Factor final cohort Gender higher odd hospitalized patient hypertension ICH incidence increase independent risk factor Inpatient Intracerebral hemorrhage Logistic regression majority male multivariate outcomes pandemic Patient patients patients with COVID-19 positive Retrospective study risk factor Risk factors Sepsis significantly smoking statistical was performed were used with COVID-19 Wuhan [DOI] 10.3389/fmed.2021.757459 PMC 바로가기 [Article Type] Medicine
Spontaneous Intracerebral Hemorrhage (ICH) associated with pregnancy and SARS-CoV-2 infection: a case reportCase Report Published on 2022-01-062022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Case report Complication coronavirus COVID-19 COVID-19 infection COVID-19 patients events Follow-up groups hemorrhage hemorrhagic event ICH increasingly Infection Intracerebral hemorrhage mechanisms multiorgan failure Occurrence outcome Patient patient with COVID-19 patients with SARS-CoV-2 Pneumonia Pregnancy pregnant Respiratory disease risk SARS-CoV-2 Spontaneous syndrome Vascular [DOI] 10.1186/s12884-021-04345-9 PMC 바로가기 [Article Type] Case Report