Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection3회분의 BNT162b2 백신 또는 BA.1 감염에 의한 Omicron 하위 계통 및 Deltacron SARS-CoV-2 중화Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] Antibody neutralization BNT162b2 BNT162b2 vaccine contribute convalescent sera dose evade geometric mean geometric mean titre geometric mean titres GMT GMTs highest Identifier immune immune evasion individual infected individual infected individuals Infection Mutation neutralization neutralization activity neutralized of BNT162b2 omicron post-dose SARS-CoV-2 SARS-CoV-2 spike sera titre Trial registration unique USA-WA1/2020 vaccinated individual Vaccine variant variants variants. [DOI] 10.1080/22221751.2022.2099305 PMC 바로가기 [Article Type] Article
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial재조합 인터페론 무장 융합 단백질 백신(V-01)을 사용한 SARS-CoV-2에 대한 이종 부스팅의 효능: 무작위, 이중 맹검 및 위약 대조 3상 시험Clinical Trial Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adverse event antibody assigned booster clinical trial common adverse event conducted COVID-19 vaccine COVID-19 vaccines dose double-blind dramatic increase Efficacy elicit eligible fatigue Fever fusion protein groups headache healthy Heterologous heterologous boosting Humoral immunity Identifier Immunity inactivated Inactivated vaccine Inactivated Vaccines Inc injection injection site intention-to-treat principle Malaysia Mild-to-moderate Neutralizing Neutralizing antibodies occurred Older omicron Omicron variant over Pain participant Participants Placebo placebo-controlled primary endpoint Randomized Randomly receive regimen robust Safe SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Events subunit Subunit vaccine Subunit vaccine. Surveillance symptomatic SARS-CoV-2 infection the epidemic titre Trial Trial registration V-01 Vaccine vaccine efficacy variant virus-neutralizing antibodies was measured were assessed [DOI] 10.1080/22221751.2022.2088406 PMC 바로가기 [Article Type] Clinical Trial
Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired AdultsArticle Published on 2022-10-042022-11-15 Journal: Neurology [Category] 바이오마커, [키워드] 95% CI accelerate Acidic adjust age Alzheimer disease analyses Analysis association Biomarker Biomarkers change changes Clinical prognosis Clinicians Cohort cortical COVID-19 CSF Disease progression driven by expressed family greater HADS Identifier IL-6 Increased independent interleukin-6 investigated Linear regression model majority marker medication MRI multivariable myeloid cell Neuroinflammation Neuropsychiatric Older pandemic participant Participants pathophysiology performed pet protein levels receptor retrospective risk scale Sex smoking Sociodemographic factor Stress stressors structures subset Symptom tested triggering variable women [DOI] 10.1212/WNL.0000000000200948 PMC 바로가기
Screening and assessment for post-acute COVID-19 syndrome (PACS), guidance by personal pilots and support with individual digital trainings within intersectoral care: a study protocol of a randomized controlled trial급성 COVID-19 이후 증후군(PACS)에 대한 선별 및 평가, 개인 파일럿의 지도 및 부문 간 치료 내 개별 디지털 교육 지원: 무작위 대조 시험의 연구 프로토콜Article Published on 2022-08-152022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] active control group activities activity applicability assigned both group both groups can be used Care chatbot comparability COVID-19 COVID-19 infection Cross-sectoral care Diagnosis Digital Digital therapy offers empowerment Endpoint evaluate evaluated example facilitate feasibility Guidance help helping Identifier IMPROVE Interdisciplinary diagnostic International Intervention intervention group long-COVID Low-threshold screening Medical rehabilitation outcome participant Participants Patient physiological platform Post-acute COVID-19 syndrome Post-COVID primary endpoints propensity score matching Psychological Randomized controlled trial Randomly receive recruited reduce reduction Registration Research return screened Screening secondary Secondary outcomes Study protocol Support supported Symptom Symptom assessment. Symptoms syndrome therapy Treatment Trial registration [DOI] 10.1186/s12879-022-07584-z PMC 바로가기 [Article Type] Article
Durable antibody responses elicited by 1 dose of Ad26.COV2.S and substantial increase after boosting: 2 randomized clinical trialsAd26.COV2.S의 1회 투여에 의해 유도된 지속적인 항체 반응 및 부스팅 후 상당한 증가: 2건의 무작위 임상 시험Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Ad26 Ad26.COV2.S age analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response Beta Beta variant binding binding antibodies binding antibody boost booster booster dose booster doses Cohort COV2.S COVID-19 determined by dose double-blind effective elicited enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated followed by groups Identifier immune memory immunization immunosorbent increase in initial magnitude Neutralization assay Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses participant Phase 2 Placebo placebo-controlled pseudotyped Randomized randomized clinical trial response robust Single-dose trials vaccination Vaccine vaccine dose variant Viral viral particle Virus neutralization virus neutralization assay. [DOI] 10.1016/j.vaccine.2022.05.047 PMC 바로가기 [Article Type] Article
Impact of COVID-19 lockdown on physical exercise among participants receiving the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention: a repeated measure studyRandomized Controlled Trial Published on 2022-07-212022-10-05 Journal: BMC Geriatrics [Category] 임상, [키워드] activities activity age approval baseline changes in clinical Controlled COVID-19 COVID-19 pandemic decrease Dementia Effect England ethics committee female functional help hypothesised Identifier Impact increase in Independence Intervention intervention arm investigated lockdown maintain male National Neurodegenerative disease participant physical physical activity physical activity level PrAISED Promoting receiving recorded reductions in Region Registration repeated reported SARS-CoV-2 significant difference sport Sports Medicine statistically significant Support Telemedicine telemedicine. therapy Trial [DOI] 10.1186/s12877-022-03239-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy of an asynchronous telerehabilitation program in post-COVID-19 patients: A protocol for a pilot randomized controlled trial코로나19 이후 환자에 대한 비동기식 원격 재활 프로그램의 효능: 파일럿 무작위 대조 시험을 위한 프로토콜Article Published on 2022-07-192022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] aerobic appear both groups clinical Combination consequence COVID-19 decrease determine discharged Efficacy evaluated Factor fatigue Follow-up functional Functional status greater hospital Identifier in both group Intervention outcome participant Patient physical platform post-COVID-19 patient Post-COVID-19 patients preventive intervention preventive interventions Primary outcome protocol Psychological Randomized controlled trial Randomly Registered rehabilitation Sample size scale severe fatigue severity strength Symptom therapeutic Trial variable [DOI] 10.1371/journal.pone.0270766 PMC 바로가기 [Article Type] Article
Evaluating the Effect of a COVID-19 Predictive Model to Facilitate Discharge: A Randomized Controlled Trial퇴원을 촉진하기 위한 COVID-19 예측 모델의 효과 평가: 무작위 통제 시험Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: Applied clinical informatics [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] 1:1 adoption Adverse adverse events Algorithm Analysis clinician complex contributed control arm control groups Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic death detectable discharge display displaying Effect EHR Electronic health record Evaluating Factor had no Health health record health system help hospice hospital Hospitalized Identifier identify Intervention intervention effect lack LOS Model one health outcome Patient Predictive primary symptom risk risk score Risk scores routine care Safe secondary study period sustained tested Trial with COVID-19 [DOI] 10.1055/s-0042-1750416 PMC 바로가기 [Article Type] Randomized Controlled Trial
Epidemiological, Radiographical, and Laboratorial Characteristics of Chinese Asymptomatic Cases With COVID-19: A Systematic Review and Meta-Analysis중국의 코로나19 무증상 환자의 역학, 방사선학적, 실험실적 특성: 체계적인 검토 및 메타분석Meta-Analysis Published on 2022-03-312022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] Antibody testing applied articles Asymptomatic Asymptomatic case Asymptomatic cases asymptomatic infection asymptomatic infections asymptomatic patients Chain Reaction Characteristics chest CT scan Chest CT scans China Chinese Combination COVID-19 COVID-19 infection COVID-19 patient CRD CT database disease course early stage effective evaluate feature Follow-up funnel plot heterogeneity Identifier identify IgM and IgG Infection initial management no symptom no symptoms Patient patients with asymptomatic performed polymerase chain reaction presymptomatic presymptomatic infection. proportion publication bias repeated Reverse transcription-polymerase chain reaction review risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections searched sensitivity analysis specific IgM subgroup analysis Symptom [DOI] 10.3389/fpubh.2022.808471 PMC 바로가기 [Article Type] Meta-Analysis
Fear of COVID-19 Among College Students: A Systematic Review and Meta-Analysis대학생들의 코로나19 공포: 체계적인 검토와 메타분석Meta-Analysis Published on 2022-03-012022-09-11 Journal: Frontiers in Public Health [Category] 치료제, [키워드] 95% CI agency Analysis caused CINAHL college college students conducted confidence interval Consensus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic cross-sectional cross-sectional study database Europe evaluation criteria exacerbated examined fear funnel plot Health highest Identifier identify include Insomnia lowest men Mental mental health mental health issues Meta-analysis Meta-analysis. meta-regression Methodological quality moderate pandemic Panic disorder Posttraumatic Stress Psychological distress PsycINFO public health Publication bia publication bias Quality random effect reached review Sample size scale searched subgroup analysis Symptoms systematic review women [DOI] 10.3389/fpubh.2022.846894 PMC 바로가기 [Article Type] Meta-Analysis