Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in miceReports Published on 2023-03-072024-09-05 Journal: EMBO Reports [Category] update2024, [키워드] COVID‐19 IFITM IFITM3 immunology interferon Microbiology, Virology & Host Pathogen Interaction SARS‐CoV‐2 [DOI] 10.15252/embr.202256660 PMC 바로가기 [Article Type] Reports
ACE2 Affects the Expression and Function of IFITM3 During SARS-CoV-2 Pseudovirus Infection in Vero E6 CellsArticle Published on 2022-12-012023-07-10 Journal: Viral immunology [Category] COVID19(2023년), [키워드] ACE2 COVID-19 IFITM3 SARS-CoV-2 type I interferon [DOI] 10.1089/vim.2022.0042
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations Meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortalityResearch article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, [키워드] 25-hydroxyvitamin D acute respiratory syndrome adaptive amplification Analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality creatinine Critical cytoplasm dead dead patient erythrocyte sedimentation rate ESR evaluate Factors Genetic Genotype genotyped Host IFITM3 Impact increased mortality indicated innate immune response Interferon-induced transmembrane protein 3 liver enzymes membrane minor allele frequency Mortality multivariate logistic regression Mutation parameters Patient PCR polymorphism positive profiles required Result SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significantly more suggested transmembrane protein uric acid viral cell [DOI] 10.1016/j.cyto.2022.155957 [Article Type] Research article
Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19중증 유행성 인플루엔자 A(H1N1) 및 COVID-19 환자에서 IFITM1 및 IFITM3의 차등 백혈구 발현Article Published on 2022-08-012022-09-11 Journal: Journal of interferon & cytokine research : the of [Category] 바이오마커, 신종인플루엔자, [키워드] addressed characteristic Clinical characteristics Clinical outcome clinical outcomes Cohort Comparisons coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 disease disease susceptibility downregulation Endosomes evaluated Evidence expression healthy control healthy controls High-dose humans IFITM IFITM1 IFITM3 individual Infection Influenza influenza A influenza A(H1N1) leukocyte leukocytes lung Lungs membrane fusion mice Mortality mRNA expression murine model nucleotide outcome outcomes pandemic pandemic influenza participant Patient Pneumonia Protective Protein respiratory respiratory infections Single nucleotide polymorphism single nucleotide polymorphisms susceptibility transmembrane underlying disease Viral viral respiratory infection viral respiratory infections virus viruses [DOI] 10.1089/jir.2022.0036 PMC 바로가기 [Article Type] Article
Genetic variants of NTCP gene and hepatitis B vaccine failure in Taiwanese children of hepatitis B e antigen positive mothersArticle Published on 2022-08-012023-06-13 Journal: Hepatology international [Category] B형 간염, [키워드] A. chronic infection Genetic variant HBeAg seroconversion HBsAg Hepatitis B virus IFITM3 NTCP rs4646287 G > type I interferons Vaccine failure [DOI] 10.1007/s12072-022-10350-7
Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis활동성 결핵 진단 테스트 개발을 위한 전 용해 말초 혈액에서 ELISA에 의한 숙주 단백질 바이오마커 평가Article Published on 2022-05-202022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] analyses assay associative barrier Biomarker Biomarkers blood sample CALCOCO2 capture cause of death caused CD274 CD52 collected combinations complex conducted confirmatory tests consequence Control correlation country COVID-19 pandemic death defined development diagnosing Diagnosis diagnostic diagnostic test differentially expressed disease Diversity downregulated ELISA ENhance eradication evaluate expression GBP1 group groups Health Health crisis IFIT3 IFITM3 improvement Improvements incidence India individuals infected individuals Infection Infectious disease information investigated Key priorities key priority Laboratory Lateral flow device lysed negative controls nine Patient peripheral profile Protein protein expression Protein target protein targets qPCR Rapid reducing required ROC SAMD9L significantly SNX10 Stratification Test the WHO Tuberculosis validation study WHO World Health Organisation [DOI] 10.3389/fimmu.2022.854327 PMC 바로가기 [Article Type] Article
Functional Single-Nucleotide Polymorphisms in the MBL2 and TLR3 Genes Influence Disease Severity in Influenza A (H1N1)pdm09 Virus-Infected Patients from Maharashtra, IndiaArticle Published on 2022-05-012023-06-23 Journal: Viral immunology [Category] 신종인플루엔자, [키워드] Gene polymorphisms IFITM3 influenza A (H1N1)pdm09 virus. MBL2 TLR3 TNFA [DOI] 10.1089/vim.2021.0179
Interferon-induced transmembrane protein 3 gene polymorphisms are associated with COVID-19 susceptibility and severity: A meta-analysisMeta-Analysis Published on 2022-04-212023-06-14 Journal: The Journal of Infection [Category] Fulltext, MERS, [키워드] COVID-19 gene polymorphism IFITM3 susceptibility [DOI] 10.1016/j.jinf.2022.04.029 PMC 바로가기 [Article Type] Meta-Analysis
IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and InfectionArticle Published on 2022-03-302023-06-03 Journal: Viruses [Category] B형 간염, [키워드] bile acid transport Entry inhibitor HBV HDV IFITM3 Infection NTCP preS1 peptide protein–protein interaction virus entry [DOI] 10.3390/v14040727 PMC 바로가기 [Article Type] Article