Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patientsImmunology Original Research Published on 2024-01-102024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] Biomarker COVID-19 IFN ISGs severity [DOI] 10.3389/fimmu.2023.1315602 PMC 바로가기 [Article Type] Immunology Original Research
Immunological Misfiring and Sex Differences/Similarities in Early COVID-19 Studies: Missed Opportunities of Making a Real IMPACTArticle Published on 2023-11-082024-09-05 Journal: Cells [Category] update2024, [키워드] CD4Temra Hydroxychloroquine ICU IFN IL-18 IL-1β obesity pDCs Remdesivir sex differences T cells Tocilizumab [DOI] 10.3390/cells12222591 PMC 바로가기 [Article Type] Article
COVID-19-related headache and innate immune response – a narrative reviewReview Published on 2023-01-012023-07-09 Journal: Neurologia i neurochirurgia polska [Category] COVID19(2023년), [키워드] IFN IL-1β IL-6 innate immune response Pain SARS-CoV-2 TLR-7 TNF [DOI] 10.5603/PJNNS.a2022.0049 [Article Type] Review
Interleukin-18 and COVID-19Original Paper Published on 2022-12-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Analysis applied association conducted Coronavirus Disease (COVID)-19 COVID-19 cytokine estimate Evolutionary biology experimental design Exploratory analysis Genetic Genome-wide association study genome-wide significant hospitalised IFN Immunity interferon interferon gamma Interleukin-18 investigated less liberal lower risk Mendelian randomisation Odds ratio precursor predicted predictor predictors Prevent randomisation severe COVID-19 severity Standard deviation vulnerability was related with COVID-19 [DOI] 10.1017/S0950268821002636 PMC 바로가기 [Article Type] Original Paper
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagyArticle Published on 2022-11-012023-07-09 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] autophagy COVID-19 IFN ORF10 SARS-CoV-2 STING [DOI] 10.1002/jmv.27965 PMC 바로가기
SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cellsArticle Published on 2022-10-282023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] IFN Immunity MicroRNAs SARS-CoV-2 virus-derived small RNAs. [DOI] 10.3389/fimmu.2022.1008084 PMC 바로가기