Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumoniaOriginal Article Published on 2023-12-012024-09-05 Journal: Journal of Medicine and Life [Category] update2024, [키워드] bacterial pneumonia C3 C4 COVID-19 CRP IFN-γ IL-10 IL-12 IL-8 TNF-α [DOI] 10.25122/jml-2023-0273 PMC 바로가기 [Article Type] Original Article
Disseminated multidrug-resistant tuberculosis and SARS-CoV-2 co-infection in a child with IL-12Rβ1 deficiencyCase Reports Published on 2023-01-012023-07-11 Journal: The Indian journal of tuberculosis [Category] COVID19(2023년), [키워드] Central nervous system IL-12 pediatric Primary immunodeficiency diseases Tuberculosis [DOI] 10.1016/j.ijtb.2022.04.008 PMC 바로가기 [Article Type] Case Reports
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunityArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] caused CD4+ CD4+ and CD8+ CD8+ T cell Cell cellular immunity Combination COVID-19 vaccine cytokine domain doses E. coli effective elicit elicited ELISA expressed female flow cytometry global pandemic granzyme groups IFN-γ IgG IgG1 IgG2a IL-12 IL-4 immune response immunized increase in induce infecting isotype long-lasting long-lasting neutralizing antibody lymphoproliferative mice N protein neutralization neutralization antibodies Neutralization antibody nucleocapsid percentage promoted Protective purified purified RBD quantified RBD recombinant Recombinant protein responses robust Saponin SARS-CoV-2 SARS-CoV-2 vaccine significantly spleen subcutaneously surrogate sVNT T cell response Test the SARS-CoV-2 Vaccine vaccine candidates vaccine group virus were measured [DOI] 10.3389/fimmu.2022.974364 PMC 바로가기
Transient and durable T cell reactivity after COVID-19COVID-19 이후 일시적이고 지속적인 T 세포 반응성Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antigen antigens Cell convalescent patient Convalescent patients coronavirus correlated COVID-19 cytokine Cytokines determine Ex vivo followed by IL-12 IL-13 IL-17 IL-2 Infection interferon interferon-γ interleukin long-lasting Longevity median N-terminal nucleocapsid protein Patient peptide peptides Polarity Protein reactivity remained respiratory retrieved SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulated synchronous T cell T cell cytokines T cell memory T helper T helper cells Transient triggered whole blood sample [DOI] 10.1073/pnas.2203659119 PMC 바로가기 [Article Type] Article
Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients눈물의 증가된 전염증성 사이토카인은 증상이 있는 COVID-19 환자의 결막 SARS-CoV-2 양성과 일치합니다Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] Biomarker Biomarkers collected Concentration conjunctival conjunctival sac Conjunctival secretion Conjunctival secretions COVID-19 patient COVID-19 patients cytokine level Cytokines determined by GM-CSF greater IFN-γ IL-10 IL-12 IL-1B IL-2 IL-4 IL-5 IL-6 IL-8 Increased Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune system magnetic bead ocular ophthalmic pathology Patient PCR testing positive Proinflammatory cytokine RNA RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity SARS-CoV-2 viral load selected significantly Swab Symptom symptomatic Tear tear film tears TNF-α Viral RNA [DOI] 10.1038/s41598-022-11285-7 PMC 바로가기 [Article Type] Article
Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2SARS-CoV-2에 대한 교차 반응성 점막 및 전신 항체 반응을 위한 열안정성 소단위 백신의 비강내 전달Article Published on 2022-05-032022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 addition Against Alpha angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Anti-RBD antibody antibody Antibody Response Antibody responses Antibody titer Antibody titers approved Beta binding binding domain Breakthrough infection breakthrough infections chitosan circulation COVID-19 COVID-19 vaccines CpG cross-reactive delivery Delta variants domain Efficacy effort enzyme exclusion FIVE genetic material help Hesitancy IgA antibodies IgG1 IgG2a IL-12 Immunity immunization IMPROVE induce inhibited interleukin interleukin-12 intranasal intranasal vaccination intranasally isotype Laboratory mice mucosal mucosal immunity mutant oligonucleotide polypeptide Prevent PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor Receptor binding domain receptor binding domain (RBD) reduce respiratory respiratory viruses response responses room temperature SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specific antibodies stability subcutaneous vaccination subunit Subunit vaccine systemic temperature the vaccine thermostable upper respiratory tract vaccination Vaccine Vaccine development Vaccine hesitancy vaccine platform variants virus [DOI] 10.3389/fimmu.2022.858904 PMC 바로가기 [Article Type] Article
Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expressionOriginal Research Published on 2022-03-212024-09-04 Journal: Oncoimmunology [Category] 대상포진, [키워드] adjuvant IL-12 Toll-like receptor Tumor vaccine type 1 interferon [DOI] 10.1080/2162402X.2022.2054758 PMC 바로가기 [Article Type] Original Research
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Increased Expression of Tim-3 Is Associated With Depletion of NKT Cells In SARS-CoV-2 InfectionTim-3의 발현 증가는 SARS-CoV-2 감염에서 NKT 세포의 고갈과 관련이 있습니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Apoptosis binding caspase caused CD147 CD26 Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CTLA-4 DCs decrease demonstrated dendritic cell dendritic cells Depletion disease severity dysfunction expressed expression expression level Genes healthy individuals IFN-γ IL-10 IL-12 IL-4 immune responses Immunopathogenesis implication Increased increased expression LAG-3 large cohort mechanism mitochondrial mitochondrial gene mitochondrial genes natural killer NKT NKT cell NKT cells outcome patients with COVID-19 PD-1 positively correlated Prognosis progression stage promote receptor receptors respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike scRNA-seq secrete secreted Sequencing analysis severe acute respiratory syndrome Coronavirus severity and prognosis Single-cell RNA sequencing stages therapeutic strategy TIM-3 up-regulated [DOI] 10.3389/fimmu.2022.796682 PMC 바로가기 [Article Type] Immunology