IL-1ra – Communicable Diseases Research

Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19

Article

Published on 2022-11-012022-11-15
Journal: The Pediatric Infectious Disease Journal
[Category] SARS, 진단, 치료기술,

IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

Article

Published on 2022-10-202022-11-15
Journal: The New England Journal of Medicine
[Category] COVID19(2023년), SARS, 진단,

[키워드] IL-1ra SARS-CoV-2
[DOI] 10.1056/NEJMc2205667 PMC 바로가기

Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave

첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응

Article

Published on 2022-07-272022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료기술, 치료법,

[키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood whole blood.
[DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article

Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19

심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링

Article

Published on 2022-07-212022-09-11
Journal: Cardiovascular Diabetology
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics proteomics. Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19
[DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article

Comprehensive Cytokine Profiling of Patients with COVID-19 Receiving Tocilizumab Therapy

토실리주맙 치료를 받는 COVID-19 환자의 종합적인 사이토카인 프로파일링

Article

Published on 2022-07-192022-09-12
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 진단,

[키워드] addition Administered administration Admission analyzed anti-cytokine anti-cytokine therapy Blood changes characterized circulating cytokine Clinical endpoints Cluster Comprehensive Concentration Coronavirus disease 2019 correlated COVID-19 criteria CSS cytokine cytokine profile Cytokine storm Cytokine storm syndrome Cytokines defined demonstrated disease severity Follow-up follow-up period G-CSF group hospitalized patient IL-10 IL-1ra IL-6 immune activation in both group increased mortality indication Inflammation interleukin Laboratory laboratory parameter multiple cytokines multiplex parameter pathophysiological mechanism Patient performed plasma Profiling Prognosis separated Severe case the patient to define Tocilizumab tocilizumab therapy tocilizumab. treatment with tocilizumab viral spread with COVID-19
[DOI] 10.3390/ijms23147937 PMC 바로가기 [Article Type] Article

Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study

면역학적 매개변수를 추가하여 COVID-19에서 임상 실험실 테스트의 한계를 노출하고 극복합니다. 후향적 코호트 분석 및 파일럿 연구

Article

Published on 2022-06-292022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] acute phase acute phase reactants Adding adopted age Alanine alanine aminotransferase Algorithm Analysis aspartate Aspartate aminotransferase association Barcelona best Biomarker C-reactive protein category CCL2 chemokines classical clinical clinical and laboratory variables clinical laboratories clinical laboratory clinical laboratory tests Clinical management clinical parameter Clinical parameters clinical variable clinical variables Cohort collected Comorbidity conducted COVID 19 patient COVID 19 patients COVID-19 COVID-19 pandemic COVID-19 patient CXCL10 cytokine Cytokines exploratory feasible fibrinogen filtration rate First wave flow cytometry fraction glomerular filtration rate IL-1ra IL-6 immune response immunological Immunological test immunological tests IMPROVE independent Inflammation Interpretation Laboratory Laboratory test Laboratory tests limitation lymphocyte neutrophil organ organ damage outcome overcome oxygen oxygen saturation pandemic patients performed phenotype pilot study Predictive predictive power predictive risk-profile. predictor Prognosis redundancy reflected SARS-CoV-2 SARS-COV-2 infection severity statistical statistical analysis survival Test two subgroup two subgroups understanding validation cohort validation cohorts variable
[DOI] 10.3389/fimmu.2022.902837 PMC 바로가기 [Article Type] Article

Gut microbiota-derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID-19: An open-label pilot study

COVID-19에 대한 새로운 보조 요법으로서 장내 미생물총 유래 신바이오틱 포뮬라(SIM01): 오픈 라벨 파일럿 연구

Article

Published on 2022-05-012022-09-12
Journal: Journal of gastroenterology and hepatology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] Admission Analysis antibody formation Antibody Response bacterial specy bifidobacteria changes in commensal bacteria Control control group controls COVID-19 COVID-19 patient database Day develop discharge Effect fecal greater Gut gut microbiota healthy Hong Kong hospital hospitalised COVID-19 patients hospitalized COVID-19 patients IgG antibody IL-1ra immune dysfunction immune markers Immunity Immunological response IMPROVE independent Infectious disease Intervention M-CSF Macrophage MCP-1 metagenomic microbiota monocyte chemoattractant protein-1 nasopharyngeal nasopharyngeal viral load Necrosis Open-label outcome pathogen Patient pilot study plasma positive pro-inflammatory probiotics. proinflammatory protocol receive receiving reduced restored SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 viral load severity of COVID-19 significant negative correlation significantly standard treatment Strains suggested therapy TNF-α were given
[DOI] 10.1111/jgh.15796 PMC 바로가기 [Article Type] Article

Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling

수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별

Article

Published on 2022-04-202022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics transcriptomics. tumor necrosis urea validation cohort variant
[DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article

CSF Biomarkers in COVID-19 Associated Encephalopathy and Encephalitis Predict Long-Term Outcome

COVID-19 관련 뇌병증 및 뇌염의 CSF 바이오마커는 장기적인 결과를 예측합니다

Article

Published on 2022-04-112022-09-11
Journal: Frontiers in Immunology
[Category] Coronavirus, COVID19(2023년), SARS, 바이오마커,

[키워드] activity acute COVID-19 antibodies antibody Antigen antigens Autoimmunity blood-brain barrier both groups Complication coronavirus disease Coronavirus disease 2019 correlated COVID-19 CSF cytokine cytokine profile Cytokine storm syndrome Cytokines develop diagnostic elevated Encephalitis Encephalopathy evaluate Follow-up functional group healthy control healthy controls Hospitalized IgG IL-10 IL-18 IL-1ra IL-6 IL-8 in both groups include Inflammation Inflammatory Inflammatory cytokines inflammatory process IP-10 manifestation MCP1 MIG neuro-COVID neurofilaments neurologic Neurological involvement neuronal neuronal antibodies. no difference no differences outcome Patient patients predict pro-inflammatory cytokine pro-inflammatory cytokines Prognosis prognostic Proinflammatory cytokine proinflammatory cytokines promoted Protein SARS-CoV-2 SARS-COV-2 infection serum serum biomarker serum biomarkers severity significantly viral-induced while
[DOI] 10.3389/fimmu.2022.866153 PMC 바로가기 [Article Type] Article

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다

Research Article

Published on 2022-01-112022-09-12
Journal: JCI Insight
[Category] 진단, 치료기술,

[키워드] activating Antibiotic treatment Bacterial bacterial coinfections BAL BAL fluid blood sample bronchoalveolar Bronchoalveolar lavage CCL7 chemokine chemokines chemotactic factor circulating Cohort collected comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients CXCL1 CXCL11 CXCL12 CXCL8 cytokine Cytokines decrease effector cell elafin elevated fluids G-CSF highlighting IL-1 β IL-17A IL-1ra Immunological response immunology Inflammation Influenza Invasive mechanical ventilation leukocyte lung Lungs Lymphocytes mechanically ventilated patient mechanically ventilated patients metalloproteinase Monocytes neutrophil neutrophilic Neutrophils NK cell NK cells parameter pathophysiology patients with COVID-19 patients with influenza Protease inhibitor protease inhibitors proteolytic activity severe coronavirus disease Tissue Inhibitor TNF- α Treatment Viral pneumonia
[DOI] 10.1172/jci.insight.155055 PMC 바로가기 [Article Type] Research Article