Th1-related transcription factors and cytokines in systemic lupus erythematosusImmunology Review Published on 2023-12-182024-09-04 Journal: Frontiers in immunology [Category] 대상포진, [키워드] IL-2 Inflammatory cytokines Lupus T-bet Th1 cell [DOI] 10.3389/fimmu.2023.1305590 PMC 바로가기 [Article Type] Immunology Review
Clinical and laboratory features in health care volunteers with inactivated SARS-CoV-2 vaccinationResearch Article Published on 2023-05-252024-09-05 Journal: Turkish Journal of Medical Sciences [Category] update2024, [키워드] CD19 COVID-19 healthcare IL-2 IL-6 vaccination [DOI] 10.55730/1300-0144.5684 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort studyArticle Published on 2022-12-012022-10-06 Journal: Lancet Reg Health Am [Category] 진단, [키워드] age All participant anti-SARS-CoV-2 BNT162b2 BNT162b2 vaccine booster Care cohort study CoronaVac COVID-19 determine dose effective end point General population groups Heterologous heterologous vaccine homologous humoral immune response IFN-γ IgG antibody IL-2 inactivated kidney liver median Medicine more difficult mRNA mRNA vaccine neutralising antibody not differ of BNT162b2 outcome Patient priming proportion Prospective prospective cohort study recipient recipients Red SARS-CoV-2 SARS-CoV-2 vaccine School secondary secreting significantly significantly higher solid organ solid organ transplant SOT T-cell T-cell responses vaccination Vaccine vaccine immunogenicity women [DOI] 10.1016/j.lana.2022.100371 PMC 바로가기 [Article Type] Article
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Adaptive immunity to SARS-CoV-2 infection: A systematic reviewArticle Published on 2022-10-102022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome adaptive Adaptive immunity addressed Alpha Antigen article B cell Biomarker case-control study caused CD4+ T cell CD8+ CD8+ T lymphocytes Cell cell types Characteristics clinical benefits Cohort studies coronavirus coronavirus disease Course COVID-19 Critically ill Critically ill patient cross-sectional CXCL9 Cytokines database disease English Evidence experimental evidence follicular HLA-DR humoral Humoral immunity IL-10 IL-13 IL-15 IL-17 IL-1α IL-2 IL-21 IL-22 IL-23 IL-4 IL-5 IL-7 immune system Immunity immunological Immunological memory immunopathological in vitro assays individuals inflammatory mediator involved leukocyte Ligand lymphocyte marker mild case Necrosis poor prognosis predominant produced programmed cell death progression Protein Regulatory T cell responsible SARS-CoV-2 SARS-COV-2 infection SciELO secretion severity Spanish subpopulation systematic review T helper T helper cell T lymphocyte T-cell Response Tfh TGF-β Th1 Th17 Th2 the antibody the disease TNF-α Treg tumor growth Vaccine variable [DOI] 10.3389/fimmu.2022.1001198 PMC 바로가기
Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled TrialArticle Published on 2022-10-062022-11-15 Journal: The Journal of Nutrition [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adhesion molecules age anti-inflammatory effect Antigen assigned baseline Biomarker Blood BMI C-reactive protein CDC chronic condition coin toss Concentration conducted Controlled coronavirus disease covariates COVID-19 COVID-19 complications COVID-19, SARS-COV-2 Cytokines diagnosed with COVID-19 Diagnosis dietary supplements double-blind dysregulated immune response Effect exacerbate ferritin group Health IL-1β IL-2 IL-6 implicated indicated individual infected with COVID-19 infections infectious conditions Inflammation inflammatory mediator intercellular Linear regression model mechanism Multiple outcomes P-selectin palmitoylethanolamide participant Placebo placebo tablet positive test result Primary outcome produced proinflammatory promote randomized placebo-controlled trial Randomly receive reduced reported RT-PCR secretion severity Sex significantly stratified treatment effect [DOI] 10.1093/jn/nxac154 PMC 바로가기
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adultsArticle Published on 2022-10-042022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Adaptive immune response antibodies antibody BCG BCG vaccination benefit booster breadth CD4+ CD8+ T-cell changes changes in chromatin Combination COVID-19 vaccines Delta Effect effector memory eight elevated ENhance Epigenetic Evidence expressing greater Heterologous highlighting IL-1β IL-2 immune response Immunity in-depth analysis India marker memory T-cell response mutant NAb Neutralizing provide revaccination SARS-CoV-2 seronegative significantly higher subset T cell T-cell Response tested TNF-α TNF-α expression trained immunity Tuberculosis vaccination Vaccine vaccine-induced immune response [DOI] 10.3389/fimmu.2022.985938 PMC 바로가기
Hybrid and vaccine-induced immunity against SAR-CoV-2 in MS patients on different disease-modifying therapiesArticle Published on 2022-10-012022-11-15 Journal: Annals of Clinical and Translational Neurology [Category] COVID19(2023년), SARS, 진단, [키워드] age Analysis antibody Antibody Response assays association cellular cellular response Cellular responses center COVID-19 infection COVID-19 vaccination ELISPOT evaluated examined groups hybrid IFNγ IL-2 immune response immune responses Immunity immunoassay immunologic response independent independent predictor Infection laboratory-confirmed Live virus microneutralization mRNA vaccines multivariate multivariate analyses New York no difference Patient post-vaccination response post-vaccine response receptor recruited SAR-CoV-2 SARS CoV-2 Sex significantly increased subset therapy vaccination Vaccine Vaccine-induced immunity were assessed [DOI] 10.1002/acn3.51664 PMC 바로가기
ASSOCIATION OF TNF-α, TGF-β1, AMPHIREGULIN, IL-2, AND EGFR WITH PULMONARY FIBROSIS IN COVID-19Short communication Published on 2022-10-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] age analyzed association blood sample chest CT scan coronavirus disease COVID-19 COVID-19 pneumonia patient Critical cytokine discharged EGFR ELISA evaluate evaluated fibrosis hospital IL-2 mechanism men Patient Pneumonia pulmonary pulmonary fibrosis Serum level severity TGF TGF-β1 the patient TNF- α TNF-α was performed women [DOI] 10.1016/j.jiph.2022.08.007 [Article Type] Short communication