IL1B – Communicable Diseases Research

Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome

생물 정보학 접근법은 COVID-19 관련 다발성 경화증 증후군에서 NOD 유사 수용체 신호 전달 경로의 중요한 역할을 보여줍니다

Article

Published on 2022-08-012022-09-11
Journal: Journal of neural transmission (Vienna, Austria : [Category] 유전자 메커니즘,

Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release

인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다

Article

Published on 2022-07-222022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal
[DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis

주요 대기 오염 물질이 COVID-19 심각도에 미치는 공동 영향: 독성 유전체 데이터 분석을 기반으로 한 예측

Article

Published on 2022-07-072022-09-11
Journal: Arhiv za higijenu rada i toksikologiju [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Air pollution AML Analysis binding biological process biological processe biological processes carbon monoxide CEBPA citokini Comparative Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complication COVID-19 complications COVID-19 patient COVID-19 transmission CTD cytokine Cytokine storm Cytokines Data analysis death rate determine disease disease complications Diseases DisGeNET dušikov dioksid English Fever Final GeneMANIA Genes identify IL10 IL1B IL6 in silico indicate Inflammation interactions komplikacije bolesti lebdeće čestice molecular molecular function network nitrogen nitrogen dioxide onečišćivači zraka Other ozon Ozone Particulate Particulate matter pathway Periodic fever physical poremećaj funkcije gena researcher resulting SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity sulphur dioxide sumporov dioksid syndrome the cytokine storm TNF TNFRSF1A ugljikov monoksid.
[DOI] 10.2478/aiht-2022-73-3631 PMC 바로가기 [Article Type] Article

Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods

기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식

Article

Published on 2022-04-282022-09-11
Journal: BioMed Research International [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2
[DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article

Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 Patients

Immunology

Published on 2022-02-222022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] Analysis Apoptosis asymptomatic infection asymptomatic subject CD14 CD160 CD33 CD68 CD8 Cell CLEC10A clinical presentation comprehensive analysis COVID-19 CSF1R develop Differentially expressed genes disease severity ENhance enriched pathway help HLA-DMA identification IL1B immune response immune responses Immunopathogenesis Inflammation KEGG LAG3 monocyte NCAM1 pathogenic PBMC positively correlated Protective S100A9 SARS-CoV-2 SARS-COV-2 infection scRNA-seq severity significantly singlecell RNA sequencing (scRNA-seq) subset surface marker Symptomatic patients the disease TRAV1-2 unique viral persistence
[DOI] 10.3389/fimmu.2022.812514 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

SARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거

Article

Published on 2022-02-012022-09-11
Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection
[DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article

Potential Genes Associated with COVID-19 and Comorbidity

COVID-19 및 동반이환과 관련된 잠재적 유전자

Research Paper

Published on 2022-01-242022-09-10
Journal: International Journal of Medical Sciences [Category] 변종,

[키워드] ACE AGT Analysis bioinformatics candidate gene CCR5 Comorbidities Comorbidity contribute Coronary artery Coronary artery disease coronavirus coronavirus disease COVID-19 CX3CR1 cytokine cytokine inhibitors cytokine receptor diabetes Diabetes Mellitus disease severity drug and vaccine development Efficacy enrichment analyses evaluated explain Factor Fenofibrate Genetic genetic factors GO term help hypertension IL1B IL1RN IL6 immune factor immune factors immune response IMPROVE individual Infection inhibitors Interaction involved KEGG KEGG pathway MBL2 NCBI NLRP3 non-immune nucleotides observé OMIM overlapping pathway Pathways performed personalised Polymorphisms Potential PPI Predictive Predictive value Prevent Prognosis protein-protein interaction provide RAAS receptor Result risk of infection SARS-CoV-2 serious COVID-19 severity signaling pathway signaling pathways susceptibility susceptibility gene TLR4 Treatment Vaccine Vaccine development Variation Viral viral infection Vitamin D with COVID-19
[DOI] 10.7150/ijms.67815 PMC 바로가기 [Article Type] Research Paper

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀

Immunology

Published on 2021-12-152022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19
[DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology

Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

신속하고 효과적인 비타민 D 보충은 혈청 INOS1, IL1B, IFNg, Cathelicidin-LL37 및 ICAM1을 변경하여 COVID-19(SARS-CoV-2) 환자에서 더 나은 임상 결과를 제시할 수 있습니다

Article

Published on 2021-11-122022-09-10
Journal: Nutrients [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 25OHD 25OHD level Acute respiratory failure Altering analyzed Better Biomarkers Blood Cathelicidin cathelicidin-LL37 clinical clinical outcomes Comorbidities Comorbidity conducted Correlation analysis COVID-19 COVID-19 case COVID-19 cases COVID-19 treatment cytokine decreased mortality effective Effectiveness evaluate evaluated healthy individual Hospital stay Hospitalization ICAM1 IFNg IL1B increased risk indicated metabolism mortality rate outcomes parameter potential mechanism potential mechanisms present Prospective Study Rapid Regulation SARS-CoV-2 serum serum biomarker Serum level serum levels serum vitamin D significantly specific serum Treatment Treatment protocol Vitamin D Vitamin D Metabolism Vitamin D supplementation Vitamin D3
[DOI] 10.3390/nu13114047 PMC 바로가기 [Article Type] Article