IL1RA – Communicable Diseases Research

Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes

순환 면역 세포 및 가용성 매개체의 통합 분석

Research Paper

Published on 2022-01-012022-09-10
Journal: Theranostics [Category] 바이오마커,

Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19

COVID-19 이후 뇌 손상, 내피 손상 및 염증 마커가 증가하고 성별에 따른 변화를 나타냅니다.

Research

Published on 2021-11-272022-09-10
Journal: Journal of Neuroinflammation [Category] MERS, 바이오마커,

[키워드] affected alteration Analysis analyzed association bioinformatics Bioinformatics analysis Brain brain injury chemokine chemokines Control controls COVID-19 COVID-19 cohort COVID-19 hospitalization Cytokines disease severity EIM elevated endothelial injury Express expressed GFAp IL10 IL15 IL1RA IL8 immune response Inflammation Inflammatory Inflammatory cytokine Inflammatory marker inflammatory markers Injury investigated IP10 male MAP2 marker matched controls MCP1 men Mortality multiplex objective organ positive profile respiratory Respiratory disease Result risk robust S100B SARS-CoV-2 Seven Sex sex differences significantly subject supplementary material susceptible syndecan Syndecan-1 TNFα were used women
[DOI] 10.1186/s12974-021-02323-8 PMC 바로가기 [Article Type] Research

Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort

입원한 페루 COVID-19 코호트에서 더 나쁜 예후와 관련된 사이토카인 프로필

Immunology

Published on 2021-09-012022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단,

[키워드] 95% confidence interval 95%CI activated adaptive analyses Analysis analyzed anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody concentration baseline Biomarker Biomarkers C-reactive protein chemokine chemokines clinical parameter Clinical parameters Cohort Concentration correlated COVID-19 COVID-19 patient creatinine criteria CRP cytokine Cytokines D-dimer D-dimer levels death determine died discharge disease severity e parameters ELISA enrolled evaluated exacerbated expression expression profile fatal COVID-19 form Frequency GM-CSF groups growth factor Growth factors hazard ratio hemoglobin hospital Hospitalization Hospitalized hospitalized COVID-19 patients identify IL-10 IL-12p70 IL-15 IL-5 IL-6 IL-8 IL1RA Immune cell immune cells Inflammation laboratory-confirmed Laboratory-confirmed COVID-19 Logistic regression longitudinal longitudinal analysis longitudinal samples lymphocyte Lymphocytes MCP-1 MIP-1α moderate disease Mortality multivariable analysis Neutrophils obesity outcome outcomes parameter Patient patient information patients with moderate Peripheral blood pro-inflammatory cytokines profile Prognosis proinflammatory Protein Quantitative Result risk factor SARS-CoV-2 IgG SARS-CoV-2 infected patient SARS-CoV-2 infected patients SARS-COV-2 infection sera severe disease severity Significant significant difference significant differences spike IgG Stratification TNFα worse prognosis
[DOI] 10.3389/fimmu.2021.700921 PMC 바로가기 [Article Type] Immunology

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다

Immunology

Published on 2021-06-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load
[DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology

Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality

독특한 염증 프로파일은 더 높은 SARS-CoV-2 급성 호흡 곤란 증후군(ARDS) 사망률과 관련이 있습니다.

Article

Published on 2021-03-012022-09-12
Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology [Category] MERS, SARS, 진단,

Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors

여성의 염증성 사이토카인 수치의 유전적 조상과 집단 차이: 진화적 선택과 환경적 요인의 역할

Research Article

Published on 2018-06-072022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulated adaptive African age alcohol allele Analysis ancestry Antigen antigen receptor Blood cells CCL11 CCL2 chemokine chemokines chronic inflammation circulating circulating cytokines cytokine Cytokines Diseases Endemic environmental factor eosinophils European examined explain exposure to Factor Factors finding gene encoding Genetic genetic difference genetic differences Genetic variant Genetic variation Health Human human immunity IFNα2 IL10 IL1RA IL4 immune immune response immune response genes immune system Immunity implicated implication individual Infection Inflammation Inflammatory Inflammatory cytokine innate and adaptive immunity involved Level living environment living environments Local malaria Migration molecular monocyte Monocytes obesity occur Part pathogen Pathogens phenotypic variance plasma Plasma levels populations pro-inflammatory Protein receptor protein red blood cells Regulation role Selection selection pressure signal significant difference significant differences smoking susceptibility systemic level thought variant Variation White blood cells women
[DOI] 10.1371/journal.pgen.1007368 PMC 바로가기 [Article Type] Research Article