Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing DialysisArticle Published on 2024-05-312024-09-05 Journal: Biomedicines [Category] update2024, [키워드] ESKD IL6 inflammatory biomarkers mortality predictor SNP TNFRSF1B [DOI] 10.3390/biomedicines12061228 PMC 바로가기 [Article Type] Article
A randomized, placebo controlled, double blinded, parallel group clinical study to evaluate the efficacy and safety of AEV01 along with standard care for elderly patients with mild COVID-19Original Research Article (Clinical) Published on 2024-02-062024-09-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] update2024, [키워드] Ayurveda COVID-19 IL6 Immunity immunomodulatory NLR Picrorhiza kurroa, AEV01 SARS-CoV-2 TNF-alpha [DOI] 10.1016/j.jaim.2023.100860 PMC 바로가기 [Article Type] Original Research Article (Clinical)
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
COVID-19: Time for a clinical classification?Article Published on 2022-10-012023-07-10 Journal: Indian journal of pathology & microbiology [Category] COVID19(2023년), [키워드] ACE2 asymptomatic COVID. COVID-19 classification GI-COVID IL6 SARS-CoV-2 [DOI] 10.4103/ijpm.ijpm_43_21
Histologic, viral, and molecular correlates of heart disease in fatal COVID-19Research article Published on 2022-10-012022-10-05 Journal: Annals of diagnostic pathology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE2 expression activated arrhythmia Arrhythmias cardiac connexin 43 Control COVID-19 disease dysfunction edema endocytosed Endothelial cell evidenced experiment expression fatal COVID-19 greater heart heart tissue histologic host response IL6 immunohistochemistry In situ hybridization induce interstitial Macrophage manifestation Migration molecular multifocal myocarditis Myocardium Myocyte nucleocapsid protein obesity perivascular predominant Protein Proteins quantified risk RNA SARS-CoV-2 spike protein SARS-CoV2 severe COVID-19 sodium Spike protein the spike protein tissue TNFα Type II Diabetes unique Viral protein viral spike protein would increase [DOI] 10.1016/j.anndiagpath.2022.151983 [Article Type] Research article
3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signalingArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] 293T 293T cell 3’UTR acute respiratory syndrome Alter Apoptosis Bioinformatic Cell cell proliferation cellular processes checked coronavirus COVID-19 cytokine cytokine signaling demonstrated down-regulation drugs growth Host host miRNA human miRNAs IL6 induce inhibit Interaction introduced mechanism miRNA miRNAs motif noncoding RNA overexpressed predicted public health threat reduce reducing regulate Regulation reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA SARS-CoV-2 S SARS-CoV-2 spike screened spike gene target TNF-α UTR Vaccine virus RNA was determined [DOI] 10.3389/fimmu.2022.924667 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker DiscoveryCOVID-19 바이오마커 발견을 위한 기계 학습을 통한 혈청 단백질체학 및 임상 데이터의 심층 표현형 결합Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 유전자 메커니즘, [키워드] analyzed Biomarker Biomarkers cardiometabolic CD200R1 Central nervous system clinical Clinical practice contributed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient dataset deep disease disease severity Diseases downregulated enrolled Factors IL6 IMPROVE Inflammation KIT LTBP2 lymphocyte lymphocyte counts machine learning MATN3 MCP1 MOST MRAP natural history neurologic neurologic disease neutrophil nine outcome pathology persistence Phenotyping Protective Protein proximity extension assay sera serological data serum biomarker serum biomarkers severe cases small sample size statistical TRANCE unique variable [DOI] 10.3390/ijms23169161 PMC 바로가기 [Article Type] Article