Immune dysregulation is an important factor in the underlying complications in Influenza infection. ApoH, IL-8 and IL-15 as markers of prognosisImmunology Original Research Published on 2024-07-262024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] APOH apolipoprotein H early immune response flu IL15 IL8 Influenza β2GPI [DOI] 10.3389/fimmu.2024.1443096 PMC 바로가기 [Article Type] Immunology Original Research
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal [DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19COVID-19 이후 뇌 손상, 내피 손상 및 염증 마커가 증가하고 성별에 따른 변화를 나타냅니다.Research Published on 2021-11-272022-09-10 Journal: Journal of Neuroinflammation [Category] MERS, 바이오마커, [키워드] affected alteration Analysis analyzed association bioinformatics Bioinformatics analysis Brain brain injury chemokine chemokines Control controls COVID-19 COVID-19 cohort COVID-19 hospitalization Cytokines disease severity EIM elevated endothelial injury Express expressed GFAp IL10 IL15 IL1RA IL8 immune response Inflammation Inflammatory Inflammatory cytokine Inflammatory marker inflammatory markers Injury investigated IP10 male MAP2 marker matched controls MCP1 men Mortality multiplex objective organ positive profile respiratory Respiratory disease Result risk robust S100B SARS-CoV-2 Seven Sex sex differences significantly subject supplementary material susceptible syndecan Syndecan-1 TNFα were used women [DOI] 10.1186/s12974-021-02323-8 PMC 바로가기 [Article Type] Research
Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot studyResearch Article Published on 2021-10-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] accompanied Biochip Case-control correlation Course COVID-19 cytokine cytokine profile Cytokines demonstrated EGF evidenced IFN-y IFN-γ IL-10 IL-1α IL-2 IL-4 IL-6 IL-8 IL8 marker MCP-1 oxidative stress parameter Patient pilot study predict presentation primary care serum severe COVID-19 severe COVID-19 patients significantly higher tested the disease the patient TNF-α VEGF were measured worsened [DOI] 10.12688/f1000research.55166.2 PMC 바로가기 [Article Type] Research Article
Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Children: One Year after the Onset of the Pandemic in a High-Incidence AreaArticle Published on 2021-10-072022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Anomaly Area cardiac involvement children conducted COVID-19 cross-sectional cytokine profiles Cytokines diagnose diagnosed disease Diseases feature ICU admission IL8 Immunological response immunomodulatory initial Intensive Kawasaki disease Laboratory lesion lymphocyte manifestation marker median age median time MIS-C multisystem inflammatory syndrome in childhood myocardial damage myocardial injury normalized one patient Onset onset of fever overlap Patient rapid response required SARS-CoV-2 SARS-COV-2 infection severity significantly higher steroid study period subpopulations Support the disease therapy Treatment ventricular ventricular dysfunction Year [DOI] 10.3390/v13102022 PMC 바로가기 [Article Type] Article
Administration of Ligilactobacillus salivarius MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional ImpactArticle Published on 2021-09-112022-11-01 Journal: Foods [Category] COVID-19, [키워드] Ligilactobacillus salivarius affected analyzed CFU changed chitinase cognitive Concentration COVID-19 decrease elderly fecal Fecal sample functional Health home Host Il19 IL31 IL8 immune factor Impact increase in Inflammatory ingestion involved log microbiota MNA nasal Nursing nursing home participated Probiotics profile recruitment SARS-COV-2 infection significantly susceptibility Trial [DOI] 10.3390/foods10092149 PMC 바로가기 [Article Type] Article
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-CoronavirusesSARS-CoV-2 및 Pan β-Coronavirus에 대한 향신료의 생물학적 활성 성분의 잠재적 면역 조절 특성Cellular and Infection Microbiology Published on 2021-08-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alleviate Anti-inflammatory antioxidant antioxidants Antiviral antiviral properties bioactive components CCL2 cellular pathway cellular pathways chemokine Clinical outcome component contributing to coronavirus COVID-19 COVID-19 severity diet Effect elevated erythroid Health Health crisis Health Organization highlight HMOX1 homeostasis host cell host cell factor Host immune response host immune responses hypercytokinemia hyperinflammation IL6 IL8 immune responses Immunity inhibiting Interleukins lethality mediators modulate Multiorgan dysfunction Nrf2 nuclear oxidative oxidative stress Pan pathway Pneumonia Potential Prevent pro-inflammatory pro-inflammatory mediator pro-inflammatory mediators promise property PROTECT protective immunity respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus spice spices sustained systemic inflammation tissue damage TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variation World Health Organization β-Coronaviruses [DOI] 10.3389/fcimb.2021.729622 PMC 바로가기 [Article Type] Cellular and Infection Microbiology