Study of microRNA expression in Salmonella Typhimurium-infected porcine ileum reveals miR-194a-5p as an important regulator of the TLR4-mediated inflammatory response살모넬라 타이피무리움에 감염된 돼지 회장에서의 마이크로RNA 발현 연구는 TLR4 매개 염증 반응의 중요한 조절자로 miR-194a-5p를 밝혀냈다.Article Published on 2022-05-212024-08-21 Journal: Vet Res [Category] 살모넬라증, [키워드] CRISPR-Cas9 ileum Immunity Infection Inflammation MicroRNAs miRNA-seq pig. salmonellosis Toll-like receptor
Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19글리 시르 시리 바 글라브라 추출물을 이용한 식품 농축 래트에서 ACE2 mRNA 및 단백질 발현을 억제합니다.Article Published on 2021-07-062022-08-31 Journal: Nutrients [Category] 유전자 메커니즘, 치료제, [키워드] ACE2 ACE2 expression ACE2 mRNA Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aldosterone angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals body weight Brain Cell component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diet dose Effect enrichment enzyme Evidence experiment expression Extract FIVE food Gene Expression glycyrrhiza glycyrrhizin Hypothesis ileum independent independent of induce inhibitory activity Mild mineralocorticoid receptor organ organs outlined PCR Placebo present protein level RATs receptor reduce reduction respiratory resulting SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant decrease small intestine Stress stress condition stress response Support suppressed susceptibility tissue tissues toll like receptor 4 virus [DOI] 10.3390/nu13072321 PMC 바로가기 [Article Type] Article
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trialCOVID-19에 대한 이트라코나졸: 전임상 연구 및 개념 증명 무작위 임상 시험Randomized Controlled Trial Published on 2021-03-192022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 비임상, 신약개발, 임상, 진단, 치료제, [키워드] 7-point ordinal scale 95% CI absence acute infection acute SARS-CoV-2 infection adequate plasma antifungal drug itraconazole antivirals assigned breath Caco-2 clinical status Clinical studies clinical study clinical trial COVID-19 cumulative score did not reduce drug concentrations Drug repurposing effective evaluated finding foundation funding geometric Geometric means Health Organization Horizon hospitalized COVID-19 patient hospitalized COVID-19 patients human Caco-2 cells ileum in vitro activity initial interim analysis itraconazole Leuven lung Lungs Melinda Gate Melinda Gates not effective Open-label Ordinal Scale outcome Preclinical preclinical studies preclinical study premature termination Prevent prevention of COVID-19 Primary outcome proof-of-concept clinical study randomized clinical trial Randomly required SARS-CoV-2 SARS-COV-2 infection showed no signal single-center study Standard of care Stool stools Transmission Transmission model Treatment Vero Viral Viral load viral load in lungs Viral transmission World Health Organization [DOI] 10.1016/j.ebiom.2021.103288 PMC 바로가기 [Article Type] Randomized Controlled Trial
Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon염증이 있는 IBD 조직에서 SARS-CoV-2의 장 수용체는 회장에서 HNF4A에 의해 하향 조절되고 결장에서 인터페론 조절 인자에 의해 상향 조절되는 것으로 보입니다Article Published on 2021-03-052022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression Alter analysed Analysis anti-TNF biopsy bowel Co-expression analysis collected Colon colonic Control COVID-19 Crohn's disease Cytokines Differential gene expression disease dysregulation entry mechanisms epithelial Factor HNF4A IBD IBD susceptibility gene ileal ileum Immunosuppressed inflamed CD ileum Inflammation Inflammatory Inflammatory bowel disease inflammatory bowel diseases inflammatory stimuli interferon intestinal intestinal inflammation intestine investigated Microarray Microarrays mucosal Necrosis network Organoid organoids Patient patients pro-inflammatory cytokine pro-inflammatory cytokines processed Prognosis regulated Regulating Regulation responders restored risk factor RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data shown significantly Single Cell single-cell therapy tissue TMPRSS2 transcriptomics ulcerative colitis upregulated upstream [DOI] 10.1093/ecco-jcc/jjaa185 PMC 바로가기 [Article Type] Article
SARS-Cov-2 infection in transplant-related biology: Where do we stand?이식 관련 생물학에서의 SARS-Cov-2 감염: 우리는 어디에 서 있습니까?Review Published on 2020-12-292022-09-11 Journal: Annals of transplantation [Category] 치료기술, 치료제, [키워드] ACE2 activities affected Allograft angiotensin Angiotensin-converting enzyme biology of SARS-CoV-2 confirmed case coronary pneumonia Coronavirus infection COVID-19 Cytokines death expressed Factor high plasma levels high risk ileum immune infected patients Infection Inflammatory response kidney lung Novel coronavirus outbreak outcomes Patient plasma Pneumonia Proinflammatory cytokine proinflammatory cytokines receive receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia Spread target cell target cells Transplant Wuhan [DOI] 10.12659/AOT.924768 PMC 바로가기 [Article Type] Review
Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus InfectionCommunication Published on 2020-09-122022-10-31 Journal: Cells [Category] Coronavirus, [키워드] Cell culture Colon Combination coronavirus Culture demonstrated develop development Factor FECV Feline coronavirus feline enteric coronavirus Feline infectious peritonitis virus feline intestinal organoids FIPV Gut ileum infect Infection isolate Mild molecular mechanism Mutation Organoid organoids persistence Population Potential Support virus [DOI] 10.3390/cells9092085 PMC 바로가기 [Article Type] Communication
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection수용체 ACE2 발현에 대한 단일 세포 RNA-seq 데이터 분석은 2019-nCoV 감염에 취약한 다양한 인간 장기의 잠재적 위험을 보여줍니다Research Article Published on 2020-03-122022-09-06 Journal: Frontiers of medicine [Category] Communicable Disease, COVID-19, MERS, SARS, [키워드] 2019-nCoV 2019-nCoV infection ACE2 ACE2 expression alveolar cell analyses Analysis analyzed angiotensin angiotensin converting enzyme AT2 bladder cell type cell types cells China dataset digestive enzyme II epithelial cells esophagus expression heart human cell human cells ileum kidney Kidney failure lung lung cell lung cells material Myocardial nCoV Novel coronavirus organ organs other organs Pathogenesis Patient physiological systems potential risk proximal tubule proximal tubule cell proximal tubule cells receptor receptor ACE2 respiratory reveal risk RNA-seq data route SARS-CoV scRNA-seq scRNA-seq data Single-cell RNA sequencing single-cell RNA-seq Symptoms target cell target cells vulnerability Wuhan [DOI] 10.1007/s11684-020-0754-0 PMC 바로가기 [Article Type] Research Article
Ileal and jejunal Peyer’s patches in buffalo calves: Histomorphological comparisonResearch Article Published on 2015-11-052023-08-30 Journal: Veterinary World [Category] E형 간염, [키워드] Histomorphology ileum Jejunum lymphoid follicle Peyer’s patch [DOI] 10.14202/vetworld.2015.1273-1278 PMC 바로가기 [Article Type] Research Article
Quantitative proteomics and bioinformatic analysis provide new insight into the dynamic response of porcine intestine to Salmonella Typhimurium양적 단백질체학 및 생물정보학 분석은 살모넬라 타이피무리움에 대한 돼지 장의 동적 반응에 대한 새로운 통찰력을 제공합니다.Original Research Published on 2015-09-032024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 살모넬라증, [키워드] Colon experimentally infected pigs ileum intestinal response iTRAQ Salmonella Typhimurium [DOI] 10.3389/fcimb.2015.00064 PMC 바로가기 [Article Type] Original Research