Relationship between serum Th1/Th2 imbalance and depression in elderly patients with COPD and its clinical implicationsResearch Article Published on 2023-09-012024-09-05 Journal: Technol Health Care [Category] update2024, [키워드] COPD Depression Imbalance Prognosis Th1/Th2 [DOI] 10.3233/THC-230665 PMC 바로가기 [Article Type] Research Article
COVID-19 and inflammatory bowel disease crosstalk: From emerging association to clinical proposalArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] abdominal pain ACE2 acute respiratory syndrome addition association Autoimmune bowel Care caused coronavirus coronavirus disease COVID-19 COVID-19 epidemic diarrhea disease downregulated enzyme Epidemic etiology exacerbate expressed feasibility Genetic IBD IL-17 Imbalance immune activation immunosuppressive drug increase induce Infection Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory response intestinal intestinal inflammation intestine lung mechanism nonspecific overlapping pathway Patient patients Pneumonia progression protective factor receptor Research respiratory inflammation risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Symptom systemic symptom the cytokine storm the SARS-CoV-2 Treatment upregulated vaccination [DOI] 10.1002/jmv.28067 PMC 바로가기
Prognosing the risk of COVID-19 death through a machine learning-based routine blood panel: A retrospective study in BrazilResearch article Published on 2022-09-012022-10-05 Journal: International journal of medical informatics [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addition artificial intelligence AUROC average Biomarker Blood blood biomarkers Brazil collected complete blood count composed conducted consequence COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity death died discharged FIVE Generalizability higher risk hospital identify Imbalance IMPROVE Laboratory Lymphocytes machine learning other organ parameter Pathogenesis Patient patients with COVID-19 phenotype Platelet Population positive RT-PCR predict primary care Probability Prognosis Retrospective study risk risk factor risk of COVID-19 SARS-COV-2 infection severity suffered the disease variable [DOI] 10.1016/j.ijmedinf.2022.104835 [Article Type] Research article
Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia케냐, 말리, 잠비아에서 매력적인 표적 설탕 미끼 3상 시험Clinical Trial Published on 2022-08-092022-09-11 Journal: Trials [Category] 말라리아, 임상, 치료제, [키워드] adaptive ARMS Attractive targeted sugar bait children Cluster cluster separation Cluster-randomized controlled trial Clusters Cohort Contamination Controlled trial core covariate covariates COVID-19 pandemic detect determine dinotefuran Effects External validity Follow-up Imbalance IMPROVE incidence include insecticidal insecticide interim analysis internal validity Intervention Kenya kill Longevity malaria morbidity mosquito density Open-label open-label design phase III trial Prevalence Primary outcome Primary outcomes randomization receive reduce reduction in reductions in Restricted resulting risk Sample size secondary outcome strength Structure sugar threat Transmission transmission pattern Trial Two-arm Validity Variation vector vector control vectors [DOI] 10.1186/s13063-022-06555-8 PMC 바로가기 [Article Type] Clinical Trial
Imbalance between alpha-1-antitrypsin and interleukin 6 is associated with in-hospital mortality and thrombosis during COVID-19Short communication Published on 2022-08-012022-10-05 Journal: Biochimie [Category] 바이오마커, 치료기술, [키워드] 95%CI adjusted Admission age alpha-1-antitrypsin Anti-inflammatory Anticoagulant BMI COVID-19 COVID-19 severity Critically ill cross-sectional D-dimer levels examined hallmark Hospitalization hospitalized patient IL-6 Imbalance in-hospital mortality Inflammation intensity involved Logistic regression marker mechanism Mortality multivariable analysis non-survivor Occurrence offer pathophysiology Patient patients performed phenotyped plasma predict Predictive proportion Protective protective factor Restoring severe COVID-19 severity Sex subset suffered survivor therapeutic thrombosis tissue variant with COVID-19 [DOI] 10.1016/j.biochi.2022.07.012 [Article Type] Short communication
The Evolution of Effort-Reward Imbalance in Workers during the COVID-19 Pandemic in France-An Observational Study in More than 8000 WorkersObservational Study Published on 2022-07-262022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] COVID-19 COVID-19 pandemic cross-sectional Effect examined expressed Factor France French Generalized Imbalance investigated Linear regression lockdown lockdowns Paramedical participant Participants Primary outcome professional professionals repetition SARS-CoV-2 Siegrist’s framework Stress Work-related stress worker worsened [DOI] 10.3390/ijerph19159113 PMC 바로가기 [Article Type] Observational Study
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including OmicronOmicron을 포함한 모든 SARS-CoV-2 스파이크 변이체의 보존된 숨겨진 틈을 인식하는 나노바디 패널Article Published on 2022-07-062022-09-11 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Accessibility Analysis antibodies antibody caused clone conserved Contact coronavirus COVID-19 detect diagnostics ELISA epitope Epitopes FIVE flow cytometric hidden Human Imbalance Infectious disease kinetic lateral flow Medicines Microscopy N-terminal domain nanobodies nanobody neutralize NTD omicron pandemic populations pseudotyped RBD Receptor-binding domain recognizing regions SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 spike variant SARS-CoV-2 variant Spike proteins spike variants target the receptor-binding domain the spike protein Vaccines Viral viral infection VOCs western blotting [DOI] 10.1038/s42003-022-03630-3 PMC 바로가기 [Article Type] Article
Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico멕시코에서 SARS-CoV-2에 감염된 환자의 산화 스트레스 바이오마커 및 사망률과의 연관성Article Published on 2022-06-172022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI absorbance alteration analyzed antioxidant association AUC baseline characteristics Biomarker Biomarkers characteristic Characteristics collected Combination COVID-19 COVID-19 patients determine died Evidence evidence of expression healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients Imbalance immune system individual infected with SARS-CoV-2 involved knowledge lead malondialdehyde MDA Mortality oxidative stress oxygen oxygen radical Patient patients with COVID-19 reactive oxygen species reactive oxygen specy receiver operating characteristic redox status ROC ROS SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples TAC total antioxidant capacity were assessed [DOI] 10.1155/2022/1058813 PMC 바로가기 [Article Type] Article
Correlation of the Imbalance in the Circulating Lymphocyte Subsets With C-Reactive Protein and Cardio-Metabolic Conditions in Patients With COVID-19COVID-19 환자의 순환 림프구 하위 집합의 불균형과 C 반응성 단백질 및 심장 대사 상태의 상관 관계Article Published on 2022-05-062022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] adaptive adaptive immune system addition Arterial hypertension B-lymphocyte Biomarker C-reactive protein cardiovascular pathology circulation Cohort condition Coronary heart disease correlated COVID-19 CRP decrease deficiency examined ferritin Imbalance immune cells immune system immunological parameter innate immune system LDH lymphocyte Lymphocytes metabolic parameter metabolic syndrome metabolism NK cell pathology Patient patients with COVID-19 Peripheral blood Pneumonia positive positively correlated reduced selected serum Serum level severe COVID-19 significantly subpopulation subset systemic inflammation T-lymphocyte T-lymphocytes [DOI] 10.3389/fimmu.2022.856883 PMC 바로가기 [Article Type] Article
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research