Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid Thyroid. tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Protective neutralizing epitopes in SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antibody therapeutics caused cell entry coronavirus COVID-19 pandemic defend elicited epitope epitope conservation etiological agent evade Health Hospitalization host cell immune defense immune system Immunity Infection molecular neutralizing antibody neutralizing epitope new virus Protective provided SARS-CoV-2 severe disease strong immune response Structure Transmissibility vaccination Vaccine variant variants variants. viral infection virus [DOI] 10.1111/imr.13084 PMC 바로가기
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infectionT 세포 수용체 레퍼토리의 종단 분석은 SARS-CoV-2 감염에 대한 항원 특이적 반응의 공유 패턴을 보여줍니다Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis breadth CD4+ T cell CD4+ T cells conducted COVID-19 detectable Diversity elevated Frequency immune defense immune response Immunity immunology individual initial Italy longitudinal municipality neutralizing antibody titers outbreak PCR persist positive remained reveal SARS-CoV-2 SARS-COV-2 infection severe disease significant increase Spike protein subsequent T cell T cell receptor T cells T cells. TCR TCRs Viral diseases was increased [DOI] 10.1172/jci.insight.151849 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition. virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Mutations of Omicron Variant at the Interface of the Receptor Domain Motif and Human Angiotensin-Converting Enzyme-2수용체 도메인 모티프와 인간 안지오텐신 전환 효소-2의 인터페이스에서 오미크론 변이체의 돌연변이Article Published on 2022-03-062022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] AABP unit ACE2 Amino acid Analysis angiotensin angiotensin-converting enzyme-2 Anxiety atomic benefit binding bonding calculated caused changes in complexity in shape and volume components computational modeling contribute evade explain facilitate Human human Angiotensin-converting enzyme immune defense in-depth analysis indicate Interaction interface mitigate Mutation observation omicron Omicron variant partial charge positive RBM receptor binding motif reveal SARS-CoV-2 shape significant changes in significant increase Spike protein Spread the spike protein Vaccines variant variant of SARS-CoV-2 virial transmission [DOI] 10.3390/ijms23052870 PMC 바로가기 [Article Type] Article
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection가용성 면역 체크포인트는 COVID-19 및 HIV 감염이 있는 과음 알코올 사용자의 조절이 잘 안 됩니다.Review Published on 2022-02-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] alcohol alcohol consumption alcohol-associated liver disease (ALD) antibacterial immunity antibodies Antiretroviral therapy ART balance binding biological function Biological functions biological significance Biomarker Biomarkers blockade blocking antibodies bloodstream Cancer circulating competition COVID-19 COVID-19 patient COVID-19 patients disease Diseases dysregulated dysregulation Effect Efficacy elevated Evidence exacerbate focus form Health healthy heavy alcohol user HIV HIV infection ICP Imbalance immune Immune cell immune cells immune checkpoint immune defense immune microenvironment immune regulation immune responses in vitro in vivo Infectious diseases Inflammation inhibitory Interaction malignant cell malignant cells membrane membrane-bound mRNA occur Pandemics pathophysiological condition pathophysiological conditions peripheral circulation plasma Plasma levels PLHIV protease public health reducing regulate Regulation Regulatory secretion self-tolerance severity of COVID-19 significantly soluble immune checkpoint stimulatory storm Surveillance Therapies Tumor user with HIV [DOI] 10.3389/fimmu.2022.833310 PMC 바로가기 [Article Type] Review
The Development of SARS-CoV-2 Variants: The Gene Makes the DiseaseReview Published on 2021-12-152022-10-29 Journal: Journal of Developmental Biology [Category] COVID-19, [키워드] accumulated mutation Affect affected Alpha variant antigenicity Beta caused characteristic concerning Contact COVID-19 COVID-19 vaccines D614G defined Deleterious delta variant described determine development E484K Effectiveness escape mutation functions Gamma genetic profile Human immune defense Immune escape initial knowledge L452R Lineage morbidity and mortality MOST Mutation mutations N501Y neutralizing antibodies (NAbs) Novel coronavirus nucleocapsid occurred other variants P681R pandemic prevalent Protein receptor binding domain (RBD) SARS-CoV-2 SARS-CoV-2 genome scrutiny severe respiratory disease severity Spike protein Spread synonymous T478K the disease the SARS-CoV-2 the Spike the spike protein Transmissibility unique Vaccines variant variant of concern (VOC) Variation viral fitness virus virus genome virus variant [DOI] 10.3390/jdb9040058 PMC 바로가기 [Article Type] Review
NAD + -consuming enzymes in immune defense against viral infectionHost-Microbe Interactions Published on 2021-12-102022-10-28 Journal: Biochemical Journal [Category] COVID-19, Fulltext, SARS, [키워드] addition Antibiotics Antiviral antiviral agent antiviral immune response Antiviral strategies antiviral therapeutics biosynthetic boost CD38 COVID-19 pandemic develop enzyme Enzymes facilitate Factors help Host immune defense immune response immune responses implicated include lack macrodomain mechanism NAD+-consuming enzymes PARP PARPs Protein SARM1 SARS-CoV-2 sirtuins Treatment Vaccine viral infection viral infections virus viruses [DOI] 10.1042/BCJ20210181 PMC 바로가기 [Article Type] Host-Microbe Interactions
Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A cohort study미국과 페루에서 SARS-CoV-2 감염에서 회복된 인구통계학적 및 임상적으로 다양한 개인에서 시간이 지남에 따라 항체 반응 중화: 코호트 연구Research Article Published on 2021-12-062022-09-12 Journal: PLoS Medicine [Category] 진단, [키워드] 293T/ACE2 cells acute respiratory syndrome coronavirus age age and sex analyses Analysis antibody Antibody Response applied assigned association Asymptomatic Birth Blood body mass body mass index Clinical characteristics clinical manifestations Clinical outcome clinical outcomes clinically Cohort cohort study collected Comorbidities Comorbidity convalescent convalescent individual convalescent individuals coronavirus 2 coronavirus disease Coronavirus disease 2019 correlation COVID-19 death declined demographic and clinical characteristics Demographic variables demographics diabete diabetes disease onset disease severity enrolled Factors help heterogeneity highlighting Hispanic hypertension identify immune defense immune response immune responses Immunity implementation in some include individual Infection limitation Linear regression Male sex medical history mild illness Multiple Multiple linear regression NAb NAb responses NAb titers NAbs nasal samples natural history Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses not differ observation participant peaked Protective pulmonary disease Questionnaires researcher respiratory response responses SARS-CoV-2 SARS-CoV-2 antibody response SARS-COV-2 infection SARS-CoV-2 spike protein serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease Sex smoking Spike protein survivorship the United State therapeutic strategy Therapeutics thought titers to define Treatment Trial registration United States Vaccine Variation variety Viral load virus virus infection were measured white [DOI] 10.1371/journal.pmed.1003868 PMC 바로가기 [Article Type] Research Article
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공Review Published on 2021-11-152022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine [DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review