immune functions – Communicable Diseases Research

Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients

코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과

Review

Published on 2022-09-012022-09-11
Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제,

Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant

SARS-CoV-2 변이체의 스파이크 단백질에서 짧은 선형 모티프의 컴퓨터 분석은 Omicron 변이체의 면역 하이잭 및 회피 메커니즘에 대한 가능한 단서를 제공합니다

Article

Published on 2022-08-082022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘,

Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway

선천성 면역을 위한 핵심 세포 유형으로서의 내피 세포: RIG-I 신호 전달 경로에 대한 집중 검토

Review

Published on 2022-07-052022-09-11
Journal: Frontiers in Immunology [Category] 치료법,

[키워드] Activation anti-viral response Atherosclerosis Bacteria Bacterial bacterial and viral infections bloodstream cardiovascular disease cardiovascular diseases caused Cell cell type close contact contact with COVID-19 danger signals DDX58 demonstrated disorder disorders dsDNA dsRNA endothelial Endothelial cell endothelial cells Endothelial dysfunction Evidence expression function heterogeneous highlight host antiviral response immune immune functions immune surveillance Immunity Infectious disease Inflammation inhibited Innate Innate immunity interferons invading pathogen Ligand Like LPS macrophages microbial infection Panax notoginseng pathogen Pathogens PPARγ provided PRR recent receptor retinoic acid review RIG-I saponins shown signal signaling pathway Surveillance translational Type Vascular endothelium viral infection viral infections virus virus infection
[DOI] 10.3389/fimmu.2022.951614 PMC 바로가기 [Article Type] Review

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

COVID-19 폐렴의 햄스터 모델 검토: 어떻게 인간이 될 수 있습니까?

Review

Published on 2022-07-012022-09-11
Journal: Veterinary pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age alveolar damage animal model characteristic clinically Coagulopathy condition consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 diagnostic Diffuse alveolar damage examined facilitate feature hamster hamsters Histopathology Human human disease humans immune function immune functions Infection Inference Inflammation information limit manifestation Mesocricetus mice moderate molecular outcome pandemic pathology pathway Patient Phodopus Pneumonia Preclinical research Research respiratory respiratory tract review rodents SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Still susceptible susceptible patient the disease therapy Vaccines variants of concern Vascular virus
[DOI] 10.1177/03009858211057197 PMC 바로가기 [Article Type] Review

Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing

Research

Published on 2022-06-302022-10-05
Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘,

[키워드] abrupt onset Anxiety biological pathways CACNA1B candidate candidate gene categories category children Cohort conducted de novo Deleterious described disorder disrupting etiology European Evidence Exome expressed functional GABRG2 Genes Genetic variant Genetic variation GRIN2A heterogeneous identification immune functions Infection infections irritability microglia Mutation nervous system neuronal Neuropsychiatric NLRC4 pathological mechanism pediatric peripheral immune response PLCG2 PPM1D RAG1 regulate selected Sequencing SGCE SHANK3 Stressor subject swings Symptom syndrome SYNGAP1 union variant WES WGS whole genome
[DOI] 10.1038/s41598-022-15279-3 [Article Type] Research

Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19

Full Papers

Published on 2022-01-282022-10-28
Journal: The British Journal of Nutrition [Category] COVID-19,

[키워드] Adhesion Molecule alteration approved association cell death cell type Clinical data Corona Corona Virus Disease 19 COVID-19 deaths decrease deficiency detrimental disease dysfunction Effect effective function Health health system homoeostasis immune functions immune response immune system impaired immune system increase Increases Infection likelihood metabolism Mild Mild symptom Organ failure overactive pathogen pathogenic mechanism Patient phenotype Prevent problem progression proinflammatory Protein reduce Registered respiratory resulting risk factor severe acute respiratory syndrome-coronavirus-2 Severe case susceptibility therapeutic option tissue tissue damage Vaccine while with COVID-19 zinc deficiency
[DOI] 10.1017/S0007114521000738 PMC 바로가기 [Article Type] Full Papers

A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients

1 분 혈액 검사는 COVID-19 환자의 면역 기능 감소 및 임상 위험 증가를 감지합니다.

Article

Published on 2021-12-062022-09-01
Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술,

COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic Profiling

Article

Published on 2021-11-292022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] acute respiratory syndrome Affect alteration caused Cell cell receptors characterized clinical outcomes complex coronavirus correlated COVID-19 COVID-19 patients CXCR4 defined Diagnosis Disease progression Effect exhibited expressed expression flow cytometry healthy blood donor heterogeneity highlight IFNGR1 immune Immune cell immune cells immune functions immune response increase in infected with SARS-CoV-2 inflammatory process less mononuclear cell patients with COVID-19 PBMCs performed Peripheral blood Profiling respiratory tract Revealed SARS-CoV-2 signaling pathway Single-cell RNA sequencing Specific subjects subset surface marker surface markers transcript viral infection was reduced
[DOI] 10.3390/biomedicines9121794 PMC 바로가기 [Article Type] Article

The effect of aerobic exercise on immune biomarkers and symptoms severity and progression in patients with COVID-19: A randomized control trial

유산소 운동이 코로나19 환자의 면역 바이오마커와 증상의 중증도 및 진행에 미치는 영향: 무작위 대조 시험

Randomized Controlled Trial

Published on 2021-10-012022-09-11
Journal: Journal of bodywork and movement therapies [Category] MERS, SARS, 바이오마커, 임상,

[키워드] aerobic Aerobic capacity Aerobic exercise affected age All participant All participants assigned baseline Baseline measurements Biomarker Biomarkers Blood both group both groups control groups COVID-19 decrease dependent variable dependent variables disease severity disorder disorders Health Organization immune immune biomarkers immune function immune functions immune marker immune system Immunoglobulin immunoglobulin A IMPROVE increase indicated infected cases interleukin interleukin-10 interleukin-6 Intervention intervention group leucocytes life Lymphocytes Mild Moderate COVID-19 mortality rates number of infected pandemic participant participated Patient patients with COVID-19 performed progression Quality of life Randomized randomized controlled study Randomly ranged respiratory respiratory symptoms severity significantly significantly increased Symptom TNF-α total score Trial two groups Vaccines Viral Viral load World Health Organization
[DOI] 10.1016/j.jbmt.2021.07.012 PMC 바로가기 [Article Type] Randomized Controlled Trial

Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19

말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.

Article

Published on 2021-10-012022-09-11
Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘,

[키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19
[DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article