Single-cell transcriptomics by clinical course of Mycobacterium avium complex pulmonary diseaseArticle Published on 2024-07-082024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Bacterial infection Disease progression Immune profile Mycobacterium avium complex pulmonary disease Single-cell RNA sequencing Treatment outcome [DOI] 10.1038/s41598-024-66523-x PMC 바로가기 [Article Type] Article
Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19Article Published on 2022-11-012022-11-15 Journal: The Pediatric Infectious Disease Journal [Category] SARS, 진단, 치료기술, [키워드] Absolute lymphocyte count activated acute phase acute respiratory syndrome Anti-inflammatory Antibody Response CD3 CD4 CD8 Cell children children with COVID-19 Clinical outcome clinical presentation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile decrease dependent on disease severity distress effector memory exhibited groups help HLADR IL-1ra IL-1β immune mechanism Immune phenotype Immune profile increase in Infection Inflammatory Laboratory parameters Mild MIS-C no difference not significantly different Patient pediatric profile prospective cohort study RANTES SARS-CoV-2 IgG SARS-CoV2 sera severe disease severity syndrome T cell T cells tumor necrosis factor-α was performed with COVID-19 [DOI] 10.1097/INF.0000000000003669 PMC 바로가기
Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomesArticle Published on 2022-11-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] administration age anti-CD20 anti-CD20 therapy Anti-SARS-CoV-2 S antibody Antibody Response Antibody titer appear B-cell CD20 cell count Clinical outcome Cohort collected Comprehensive COVID-19 COVID-19 infection COVID-19 vaccination death demographic demonstrated diagnosed with COVID-19 died disease Disease modifying therapy effective enrolled female FIVE Follow-up healthy control healthy controls humoral Humoral immunity Humoral response ICU care Immune profile immunoglobulins incidence increased risk investigation less longitudinal Lymphocyte count Multiple multiple sclerosis outcome Patient preventing infection profile reduced required Responder response to vaccination Result retrospective SARS-CoV-2 spike sclerosis serum severe disease significantly lower single-center study therapy Treatment vaccinated against COVID-19 vaccination Vaccine [DOI] 10.1016/j.msard.2022.104079 [Article Type] Article
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West AfricaArticle Published on 2022-10-032022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ABO ABO blood grouping ABO blood groups acute respiratory syndrome African anti-SARS-CoV-2 antibody antibodies antibody association Asymptomatic Asymptomatic case Blood Blood Group Clustering comparison Concentration coronavirus coronavirus disease correlations COVID-19 COVID-19 severity cytokine cytokine level decrease discrepancy disease severity Eotaxin Factor genetic background group groups Host identify IL-6 IL-8 immune marker Immune profile immune response individuals Kruskal-Wallis Mann-Whitney U test Mild Multiple Multiplex assay offer participant PCR-confirmed performed phenotype plasma Probing proportion quantification recorded reduced regression analysis significantly Spearman statistically significant symptomatic symptomatic and asymptomatic symptomatic patient tested two-tailed was performed was used West West Africa [DOI] 10.1186/s12916-022-02571-2 PMC 바로가기
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemiaArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] accelerated antibody baseline binding binding activity binding antibody Characteristics clearance COVID-19 COVID-19 disease COVID-19 disease severity Critical death defined development disease disease severity dissemination effective Evolution examined FcγR feature function highlight humoral humoral immune response IgG IgG3 immune immune clearance immune function Immune profile independent Kinetics Longitudinal data longitudinal data modeling maturation monoclonal Mortality natural infection neutralization outcome persistence persistent persistent SARS-CoV-2 plasma viremia plasma predict progression provide SARS-CoV-2 SARS-CoV-2 replication severe COVID-19 Specificities subunit system serology viral clearance viral replication Viremia [DOI] 10.1128/mbio.01577-22 PMC 바로가기
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort studyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] abnormality acute infection acute respiratory syndrome anti-cellular antibodies anti-SARS-CoV-2 IgG antibodies antibody Antibody Response Antiviral baseline blood sample CD8 changes in characterized chemokine chemokines clinical cohort study coronavirus coronavirus disease COVID-19 Critical Critical disease Critical illness cytokine Cytokines defined Diagnosis evaluated feature flow cytometry Follow-up humoral humoral immune response Humoral response IgG IgGs IL-13 IL-2 IL-4 immune Immune profile immunological IP-10 key factor lymphocyte Lymphocytes lymphopenia Measures Neutrophil extracellular trap outcome Patient patients with COVID-19 positive Primary outcome Quantitative recruitment regulatory T cells Research Result SARS-CoV-2 serum serum cytokine Serum level serum titer strongly related sustained T cell T cells the patient variable were assessed [DOI] 10.3389/fimmu.2022.943563 PMC 바로가기
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종Article Published on 2022-08-022022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology Transcriptome triplex vaccination vaccination schedule vaccine candidate [DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article