In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2
remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.
Research Article
[키워드] absence
accumulation
acting
Affect
animal model
animal models
Antiviral
antiviral drug
approved
Author
backbone
changes in
characterisation
circulating SARS-CoV-2 variant
Clinical management
conserved
coronavirus
COVID-19 patients
displaying
drug-resistant
EIDD2801
Evidence
evidence of
excess
FDA
FDA approval
Frequency
genetics
immune
immune pressure
immune selection
implication
in vitro
indicate
low frequency
morbidity and mortality
mutants
Mutation
no evidence of
not affect
Nsp12
nucleoside
occurred
overcome
passage
patients
polymerase
Population
predicted
provide
RDV
Remdesivir
replication advantage
residue
resistant mutants
responsible
risk
RNA virus
RNA-dependent RNA polymerase
SARS-CoV-2
SARS-CoV-2 genome
SARS-CoV-2 variant
SARS-CoV-2 variants
selected
sensitivity
Sequencing
single mutation
small molecule
Substitution
substitutions
Surveillance
the SARS-CoV-2 genome
Transmission
Treatment
treatment of COVID-19 patients
variants of concern
Viral
viral replication
virus
viruses
widespread
worldwide pandemic
[DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article