Assessing the Burden and Cost of COVID-19 Across Variants in Commercially Insured Immunocompromised Populations in the United States: Updated Results and Trends from the Ongoing EPOCH-US StudyOriginal Research Published on 2024-01-132024-09-05 Journal: Advances in therapy [Category] update2024, [키워드] Cancer Chronic kidney disease COVID-19 Epidemiology healthcare resource utilization Immune suppression Immunocompromised Primary Immunodeficiency Transplant [DOI] 10.1007/s12325-023-02754-0 PMC 바로가기 [Article Type] Original Research
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascadearticle Published on 2023-10-272024-09-05 Journal: BMC Complementary Medicine and Therapies [Category] update2024, [키워드] Apoptosis CD 73 CD39 Combination Immune suppression Target delivery [DOI] 10.1186/s12906-023-04212-4 PMC 바로가기 [Article Type] article
Filarial infections compromise influenza vaccination efficacy: Lessons from the mouseReview Published on 2023-03-012023-06-24 Journal: Immunology letters [Category] 신종인플루엔자, [키워드] helminth infection immune modulation Immune suppression Influenza vaccination [DOI] 10.1016/j.imlet.2023.03.001 [Article Type] Review
Effectiveness of Sotrovimab in the Omicron Storm Time: A Case SeriesObservational Study Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] Chronic kidney disease Immune suppression monoclonal antibody treatment Omicron variant SARS-CoV-2 Sotrovimab variant of concern [DOI] 10.3390/v15010102 PMC 바로가기 [Article Type] Observational Study
Third Early “Booster” Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody ResponsesArticle Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] administration allogeneic HSCT Anti-spike antibody Antibody Response Beta BNT162b2 vaccine booster Breakthrough infection can be used circulation correlated COVID-19 COVID-19 vaccine Delta delta variant dose enzyme France healthy hematopoietic high-risk population HSCT HSCT immunocompromised patients HSCT recipient humoral Humoral response immune immune protection Immune suppression immunoassay Immunocompromised immunocompromised individuals Immunocompromised patients Immunosuppressed individual marker monoclonal antibody Neutralization assay neutralization titer Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody response omicron preventive measure PROTECT Protein question raised recipient recipients response SARS-CoV-2 SARS-CoV-2 variant sensitivity significantly lower STEM Strategy Support tested the vaccine Transplant vaccination vaccine dose variant variant of concern variants [DOI] 10.3390/v14091928 PMC 바로가기
Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective StudyCOVID-19 폐렴 및 호흡부전 환자의 병원 내 사망률에 대한 중간 지역 Proadrenomedullin 및 체외 인터페론 감마 생산의 예후적 가치: 관찰적 전향적 연구Observational Study Published on 2022-07-302022-09-11 Journal: Viruses [Category] MERS, 바이오마커, 임상, [키워드] 95%CI Admission Adult patients adverse outcome adverse outcomes AUROC best Biomarker cause characterized Coagulopathy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pneumonia COVID-19 vaccination cut-off cut-off point Deceased dysregulation endothelial damage enrolled Enrollment Evidence evidence of females Gamma groups Hospital mortality Hospitalization IFNγ immune dysregulation Immune suppression Immunocompromised patients in vitro in-hospital mortality infection risk interferon interferon gamma median age mid-region proadrenomedullin MONITOR Mortality MR-proADM Negative predictive value Non-COVID-19 observational study PaO2:FiO2 Patient patients with COVID-19 Pneumonia predict Predictive value predictive value) Production Prognostic factor Prospective quantiferon monitor. radiologic respiratory Respiratory failure SARS-CoV-2 sensitivity significantly specificity subset survivor the median value were measured with COVID-19 with infection [DOI] 10.3390/v14081683 PMC 바로가기 [Article Type] Observational Study
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling중증 급성 호흡기 증후군 코로나바이러스 2 ORF8 단백질은 HSP90B1 신호 전달을 표적으로 하여 I형 인터페론 생산을 억제합니다Article Published on 2022-05-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid Antiviral caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 exhibit explanation function Genotype genotypes global pandemic high mutation rate high mutation rates HSP90B1 IFN-I IFN-β immune evasion Immune suppression implication individual induce inhibit inhibitory effect interact interferon interferon response investigated IRF3 ISG15 leucine MDA5 mechanism Mutation no difference nuclear translocation ORF8 ORF8 protein pandemic pathogenic pathway poly(I:C) Production Protein provide reported respiratory RIG-I SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus signaling pathway strain suppress targeting the SARS-CoV-2 Treatment Type type I interferon variant [DOI] 10.3389/fcimb.2022.899546 PMC 바로가기 [Article Type] Article
COVID-19 associated coagulopathy and thrombosis in cancerResearch article Published on 2022-05-012022-10-05 Journal: Thrombosis research [Category] COVID19(2023년), SARS, 임상, [키워드] adverse outcome amplify anti-cancer treatment Antithrombotic Cancer cancer patient caused clinical study clinically Coagulation Coagulopathy Combination COVID-19 COVID-19 infection COVID-19 vaccination D-dimer disease Disseminated intravascular coagulation effective Efficacy and safety evaluated haematological malignancy hypercoagulable immune response Immune suppression IMPROVE incidence Infection intensity lung cancer management outcome Patient patients Prophylaxis Pulmonary embolism risk Safe SARS-CoV-2 selected seroconversion rate Severe COVID-19 Infection Specific thromboembolic complications thrombosis thrombotic microangiopathy vaccination venous thromboembolic [DOI] 10.1016/j.thromres.2021.12.006 [Article Type] Research article
Immune Suppression in Allogeneic Hematopoietic Stem Cell TransplantationArticle Published on 2022-04-242024-09-04 Journal: Handbook of experimental pharmacology [Category] 대상포진, [키워드] acute graft-versus-host disease allogeneic hematopoietic stem cell transplantation Immune suppression [DOI] 10.1007/164_2021_544 PMC 바로가기 [Article Type] Article
Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2SARS-CoV-2의 PLPro에 대한 클로로퀴논과 하이드록시클로로퀴논의 결합에 대한 전산 조사Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Amino acid amino acid residue anticipated approved binding binding affinity carried Chloroquine cleavage complex conformational coronavirus SARS-CoV-2 COVID-19 docked drug target effective Epidemic FDA FDA approved drug HCQ Hydroxychloroquine identify Immune suppression inhibitor inhibitors of SARS-CoV-2 integrity involved MDs mechanism mechanism of action molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular target Mortality MPro novel Novel coronavirus pandemic Papain PLPro polyprotein processing protease repurposing rising SARS-CoV-2 SARS-CoV2 Simulation study the SARS-CoV-2 therapeutic interventions therapeutic targeting [DOI] 10.1080/07391102.2020.1844804 PMC 바로가기 [Article Type] Article