Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study건강한 성인에서 이종 및 동종 불활성화 및 아데노바이러스 매개 COVID-19 백신 요법의 안전성 및 면역원성: 전향적 코호트 연구Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Adults adverse event adverse events Antibody Response AstraZeneca ChAdOx1 ChAdOx1-S circulating variants combinations CoronaVac country COVID-19 COVID-19 vaccine COVID-19 vaccines dose doses Efficacy Evidence evidence of followed by group groups healthy Heterologous heterologous adenoviral vector heterologous vaccine homologous IgA response immune response immune responses immunized immunogenicity inactivated Inactivated vaccine interferon gamma Mild neutralizing activities Neutralizing activity prospective cohort study reactogenicity Receptor-binding domain referred to regimen Safety Serious Adverse Event Serious Adverse Events supply shortage vaccination Vaccine variants variants of concern Viral viral vectored. wild-type [DOI] 10.1080/21645515.2022.2029111 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivitySARS-CoV-2 변이체 B.1.617 분석: 숙주 친화성, 단백질 분해 활성화, 세포-세포 융합 및 중화 민감도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity Adenovirus adenovirus vaccine Amino acid B.1.617 caused cell-cell fusion cell–cell fusion cells Characteristics Convalescent patients COVID-19 pandemic D614G variant Delta escaped furin host tropism human cells immunized inactivated Inactivated vaccine India Infection Infectivity L452R mAbs Mutation mutations neutralization neutralization activities neutralization activity neutralization. pathogenicity proteolytic activation pseudotyped pseudotyped virus Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera T478K Transmissibility transmitted variant variants viruses volunteers [DOI] 10.1080/22221751.2022.2054369 PMC 바로가기 [Article Type] Article
From Alpha to Omicron BA.2: New digital RT-PCR approach and challenges for SARS-CoV-2 VOC monitoring and normalization of variant dynamics in wastewaterArticle Published on 2022-11-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach circulation Concentration COVID-19 COVID-19 pandemic discrimination Epidemic fecal France Genome sequencing greater human population immune response immunized incidence Local MONITOR New normalization omicron Paris pathogenicity Patient PMMoV populations prevalent proportion public health resulting risk RT-PCR SARS-CoV-2 selection of variant Sequencing Severity of infection specific mutation Spread statistically strain subject suggested the SARS-CoV-2 genome Transmissibility Vaccination strategy Variability variant variants of concern Variation viral dynamics viral spread virus VoC VOCs wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157740 PMC 바로가기
Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variantsArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analysed B.1 B.1.617.2 BBIBP-CorV booster vaccination ChAdOx1-S Combination country COVID-19 elicited exhibited Gam-COVID-Vac greater Heterologous heterologous vaccination homologous immunized information mRNA-1273 mRNA-1273 vaccines Neutralizing Neutralizing antibodies non-replicative P.1 participant percentage Population protocol protocols provided SARS-CoV-2 second dose serum shortage significantly significantly lower vaccination Vaccination strategies Vaccination strategy Vaccine variant variants of concern. viral vector-based [DOI] 10.1016/j.vaccine.2022.10.021 PMC 바로가기
Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021-22: a status-based multi-variant modelArticle Published on 2022-11-032022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] affecting analysis Analysis approach average baseline level carried caused circulation conducted cross deaths disease epidemiological events expressed France French Generation time globe heterogeneity immunized incidence Invasion investigated knowledge Multi-variant model omicron outbreak parameter rapidly spreading disease Region regions replaced reported SARS-CoV-2 SARS-COV-2 infection Spread Transmissibility. transmission potential Uncertainty variant [DOI] 10.1186/s12879-022-07821-5 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interactionArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting-enzyme-2 binding binding interaction blocking virus entry Brown caused characterized coronavirus demonstrated disease ELISA enzyme-linked immunosorbent evaluate evaluated feasible global pandemic immunization immunized Immunoglobulin immunoglobulin Y in vitro Infection inhibit kDa Laying Laying hens molecular weight Neutralizing nucleocapsid purified RBD RBD-ACE2 Receptor binding domain Receptor-binding-domain SARS-CoV-2 SARS-CoV-2. SDS-PAGE serum Specific spike glycoprotein [DOI] 10.1016/j.intimp.2022.109280 PMC 바로가기
SARS-CoV-2 Infection Causes Hyperglycemia in CatsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome blood glucose cats cause Cell cells conducted contribute coronavirus coronavirus disease COVID-19 diabete diabetes dysregulation Endocrine Ex vivo exhibited experiment experimental evidence expressed High dose hyperglycemia immune protection immunized in vivo infect Infection islet Isolated lack pancrea pancreas pancreatic Patient Protein Research researcher SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA Spike protein staining tissue viruses viruses. [DOI] 10.1093/infdis/jiac143 PMC 바로가기
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기